New concepts on mechanisms underlying disordered movement: Force generation impa

描述（由申请人提供）：肌肉力量的产生为人类运动提供了基础，因此对最佳健康和生活质量至关重要。分子生物学、神经科学、遗传学和其他医学专业领域的最新进展揭示了中枢神经系统和肌肉系统之间复杂的界面。鉴于在受伤和疾病后恢复运动功能的重要性，有必要在许多有助于研究力量产生的学科之间进行科学讨论。这个为期5天的研究务虚会将汇集在基础，应用和临床科学的研究人员，这些研究人员处于与广泛的神经肌肉骨骼条件下的力产生机制和损伤相关的研究前沿。拟议中的研究务虚会是第五次由美国物理治疗协会研究科主办的此类活动，将于2009年8月9日至13日在加利福尼亚州蒙特雷的Asilomar会议场地举行。务虚会将遵循戈登式的基本形式，旨在促进讨论和自由交流意见，并为所有与会者提供建立联系的机会。PI预计将吸引研究生，博士后研究员，初级研究人员和高级研究人员的混合，他们参与了调查力控制在受损和非受损运动中的作用的研究。除了开幕式和闭幕式外，还安排了为期3天的全体会议。每一天的一般主题将解决一个特定的机制受损的力量产生控制：1）在肌肉水平的控制，2）在肌肉协调水平的控制，和3）在中央激活水平的控制。演讲，互动海报会议和重点讨论将被用来鼓励知识交流，并制定一个包容性和渐进的当代理解康复干预措施如何演变，以符合国家的最先进的科学观点。预计拟议的研究务虚会将解决重要问题，这些问题可以推动制定和最终实施干预措施，这些干预措施可以针对导致受伤或疾病后运动障碍的特定力量障碍。 公共卫生相关性：受伤和疾病后肌肉力量的恢复对于恢复正常运动和最佳身体功能至关重要。最近的科学进步使这成为人类运动科学研究的一个关键节点，需要在各个科学学科之间进行对话和建设性的互动，以推进这一领域的知识。拟议的研究务虚会将解决一些重要问题，这些问题可以推动干预措施的制定和最终实施，这些干预措施可以针对导致受伤或疾病后运动障碍的特定力量障碍。

DESCRIPTION (provided by applicant): Muscle force generation provides the foundation for human movement, and therefore is essential for optimal health and quality of life. Recent advances in the areas of molecular biology, neuroscience, genetics and other medical specialties have shed light on the complex interface between the central nervous system and the muscular system. Given the importance of restoring motor function following injury and disease, there is a need for on-going scientific discourse among the many disciplines that contribute to the study of force generation. This 5 day research retreat will bring together researchers in the basic, applied and clinical sciences that are at the cutting edge of investigation related to mechanisms and impairments in force generation across a wide spectrum of neuromusculoskeletal conditions. The proposed research retreat is the fifth such event sponsored by the Section on Research of the American Physical Therapy Association and will be held August 9-13, 2009 at the Asilomar Conference Grounds in Monterey CA. The retreat will follow the basic Gordon-style format and is designed to promote discussion and free exchange of ideas as well as networking opportunities for all participants. The PIs expect to attract a mix of graduate students, post-doctoral fellows, junior researchers and senior investigators who are involved with studies that investigate the role of force control in impaired and non-impaired movement. Apart from the opening and closing sessions, 3 full days of plenary sessions are scheduled. The general theme of each day will address a specific mechanism underlying impaired force generation control: 1) control at the muscle level, 2) control at the muscle coordination level, and 3) control at the central activation level. Presentations, interactive poster sessions, and focused discussions will be used to encourage knowledge exchange and to develop an inclusive and progressive contemporary understanding of how rehabilitation interventions may evolve to be in line with state-of-the-art scientific views. It is expected that the proposed research retreat will address important issues that can drive the development and eventual implementation of interventions that can be targeted to specific force impairments responsible for movement disorders after injury or disease. Public Health Relevance: The restoration of muscle force generation following injury and disease is essential for the return of normal movement and optimal physical function. Recent scientific advances make this a critical junction in the study of human movement science, wherein dialogue and constructive interaction among various scientific disciplines is needed to advance knowledge in this area. The proposed research retreat will address important issues that can drive the development and eventual implementation of interventions that can be targeted to specific force impairments responsible for movement disorders after injury or disease.