Collaborative Observational Study of Myopia in COMET Children 2 (COSMICC2) Chair

COMET 儿童近视协作观察研究 2 (COSMICC2) 主席

• 批准号: 7892866
• 负责人: Jane E. Gwiazda
• 金额: $ 6.93万
• 依托单位: NEW ENGLAND COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892866
• 关键词: 11 year old; 16 year old; 17 year old; 7 year old; Adolescent; Adult; African American; Age; Child; Clinical; Cohort Studies; Contact Lenses; Cornea; Data; Enrollment; Environmental Risk Factor; Esophoria; Ethnic Origin; Ethnic group; Eye; Glass; Growth; Hispanics; Hour; Individual; Intervention; Learning; Length; Literature; Measurement; Myopia; Observational Study; Occupational; Operative Surgical Procedures; Optical Coherence Tomography; Parents; Pathology; Physiologic Intraocular Pressure; Refractive Errors; Risk; Risk Factors; Subgroup; Testing; Thick; Time; Vision; Work; base; cohort; ethnic difference; high intraocular pressure; lens; macula; predictive modeling; response

DESCRIPTION (provided by applicant): Limited data are available on the slowing of myopia progression, its eventual stabilization, and related risk factors. Juvenile-onset myopia typically is thought to stop progressing at 15 -16 years of age, yet data from adults show that progression can sometimes continue at least through the 20's. Analysis of refraction data from subjects enrolled in the Collaborative Observational Study of Myopia in COMET Children (COSMICC) shows that currently, at an average age of 17 years, myopia has stopped progressing in only 42% of the cohort. This group of ethnically diverse myopic subjects has 7-8 years of standardized, reliable measurements of refractive error and ocular components, with outstanding retention of 93%. Thus, this cohort provides a unique opportunity to characterize progression and stabilization of myopia and to learn how they are influenced by intrinsic (e.g., age, ethnicity) and environmental factors (e.g., type of lens worn, near work and outdoor activities) identified from this study and from the literature. With the higher amounts of myopia found in some of our subjects (22% with > 6.0 D), we also plan to investigate the association of increased progression and axial elongation with intraocular pressure (IOP), central corneal thickness (CCT), and macular thickness. These results will help to identify individuals with increased risk of myopia-related pathology as well as help guide the selection and timing of interventions, including vision correction surgery. By studying this cohort for an additional 5 years, this application seeks to accomplish the following aims. Aim 1: To use the Gompertz and other functions to characterize the course of myopia in the 58% of the COSMICC cohort with progressing myopia and to develop predictive models based on previously identified, intrinsic risk factors (age, ethnicity, and parental myopia). Aim 2: To test hypotheses related to environmental risk factors (e.g., type of lens worn, near work and outdoor activities) for myopia progression and stabilization in this well-characterized cohort of myopes. Aim 3: To test hypotheses related to the association of IOP, CCT, and macular thickness with changes in axial elongation and myopia progression in COSMICC subjects. This application is for the COSMICC2 Study Chair. Separate applications have been submitted by the 4 clinical centers and the Coodinating Center.

描述（由申请人提供）：关于减缓近视进展、最终稳定以及相关风险因素的数据有限。通常认为青少年发病的近视会在 15 -16 岁时停止进展，但成年人的数据显示，进展有时至少会持续到 20 多岁。对 COMET 儿童近视合作观察研究 (COSMICC) 受试者的屈光数据分析表明，目前，在平均 17 岁的人群中，只有 42% 的人近视停止了进展。这组不同种族的近视受试者对屈光不正和眼部成分进行了 7-8 年的标准化、可靠测量，保留率高达 93%。因此，该队列提供了一个独特的机会来表征近视的进展和稳定，并了解本研究和文献中确定的内在因素（例如年龄、种族）和环境因素（例如佩戴的镜片类型、近距离工作和户外活动）如何影响近视。由于我们的一些受试者中近视程度较高（22% > 6.0 D），我们还计划研究进展增加和眼轴伸长与眼压 (IOP)、中央角膜厚度 (CCT) 和黄斑厚度的关系。这些结果将有助于识别近视相关病理风险增加的个体，并有助于指导干预措施（包括视力矫正手术）的选择和时机。通过对这个队列进行额外 5 年的研究，该应用程序旨在实现以下目标。目标 1：使用 Gompertz 和其他函数来表征 58% 的 COSMICC 队列中近视进展的患者的近视病程，并根据先前确定的内在风险因素（年龄、种族和父母近视）开发预测模型。目标 2：测试与环境风险因素（例如佩戴的镜片类型、近距离工作和户外活动）有关的假设，以了解这一特征明确的近视人群的近视进展和稳定情况。 目标 3：检验 COSMICC 受试者眼压、色温和黄斑厚度与眼轴伸长变化和近视进展之间关系的假设。此申请适用于 COSMICC2 研究主席。 4个临床中心和协调中心已分别提交申请。