Passive Cavitation Image-Guided Ultrasound-Mediated Drug Delivery for Atheroma Th
Passive Cavitation Image-Guided Ultrasound-Mediated Drug Delivery for Atheroma Th
批准号:
8003631
负责人:
Kevin Joseph Haworth
金额:
$4.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-09-01 至 2012-08-31
关键词:
AcousticsAnti-Inflammatory AgentsAnti-inflammatoryArterial Fatty StreakArteriesCardiovascular systemClinicalCyclodextrinsDiseaseDrug Delivery SystemsEncapsulatedExposure toFamily suidaeFeedbackGasesGenesGoalsHealth SciencesImageLiposomesMapsMediatingPharmaceutical PreparationsPhospholipidsPhysiologic pulsePhysiologicalSolutionsTechniquesTexasTherapeuticTissuesUltrasonographyUniversitiesUse of New TechniquesVesicleaqueousimprovedpublic health relevancerosiglitazone
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Traditional means to identify and treat arterial disease are hampered by an inability to localize atheroma extent and composition. New techniques using targeted echogenic liposomes (ELIP) are being explored as possible solutions to overcome these problems. ELIP are phospholipid vesicles enclosing both aqueous and gaseous spaces. Therapeutics, such as drugs or genes, can be loaded into the ELIP. Furthermore, it has been seen that upon exposure to pulsed ultrasound, the therapeutic can be released from the ELIP and made available for delivery to nearby tissue. The encapsulated gas allows the ELIP to be imaged with a clinical ultrasound scanner and the therapeutic to be delivered via cavitation nucleation. The principal aim of this proposal is to develop techniques that will provide spatially resolved, noninvasive feedback for ultrasound-mediated delivery of a therapeutic to an arterial wall using ELIP. To achieve this aim, two specific aims will be investigated. 1) The acoustic emissions of insonified ELIP, as recorded by a passive ultrasound array, will be correlated with release of an anti-inflammatory (rosiglitazone-cyclodextrin). Subsequently, a spatial map of the emissions, and correlated therapeutic release, will be created. 2) Passive imaging of the insonified ELIP will be correlated with the delivery of the therapeutic to an ex vivo porcine artery. Successful completion of these studies will contribute significantly to the long-term goals of the Holland and McPherson Labs at the Universities of Cincinnati and Texas Health Sciences Center-Houston to trigger and enhance the delivery of a therapeutic for improved physiologic cardiovascular flow.
PUBLIC HEALTH RELEVANCE: The proposal seeks to develop passive cavitation images for ultrasound-mediated local release and enhanced delivery of an anti-inflammatory drug for atheroma treatment using echogenic liposomes.
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会议论文
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项目类别:
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资助金额:$5.35万
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依托单位:
海外基金