UIC Animal Facility Improvement Grant

UIC 动物设施改善补助金

• 批准号: 7857576
• 负责人: Jeffrey D Fortman
• 金额: $ 50万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7857576
• 关键词: Animal Housing; Animal Model; Animals; Area; Caring; Chicago; Ensure; Environment; Eye; Eye diseases; Grant; Housing; Hypoxia; Illinois; Institution; Life; Light; Measures; Monitor; Ophthalmology; Oxygen; Panthera leo; Recommendation; Research; Research Institute; Rodent; Time; Transportation; Universities; Vision; Vision research; animal care; animal facility; eye dryness; guide for the care and use of laboratory animals; instrumentation; meetings; microbial; programs; research study; square foot; vision science; visual performance

DESCRIPTION (provided by applicant): The objective of the University of Illinois at Chicago's "UIC Animal Facility Improvement Grant" is to renovate and expand the animal facility to meet the increasing demand of animal use for vision related research, which cannot be accommodated by the institution's centralized animal facility. This objective will be achieved by renovating and enhancing the satellite animal facility in the Department of Ophthalmology and Visual Sciences to create an animal housing environment essential for performing vision related studies. Specifically, a 900 sq. ft. room in the Lions of Illinois Eye Research Institute (LIERI) will be re-constructed to meet the recommendations of the Guide for the Care and Use of Laboratory Animals (Guide) for housing rodents. The room will be partitioned into several compartments, a light-controlled compartment for light sensitive experiments, an environmentally controlled compartment for establishing dry-eye disease animal models, and a hypoxia compartment for generating oxygen related eye disease animal models. The department will also centralize existing vision research instrumentation used to monitor and measure visual performance functions in living animals in areas contiguous to the animal holding areas. The proposed renovation will ensure the continued compliance of the campus-wide animal care program with the recommendations of the Guide and further strengthen the quality of the overall program in terms of housing, care and veterinary oversight, while at the same time creating an ideal environment to facilitate vision research at UIC. In addition, a centralized satellite animal facility for vision research will minimize the transportation of animals and potential microbial contamination of both experimental animals and animals maintained in the rodent colonies of the institution's centralized animal facility.

描述（由申请人提供）：伊利诺伊大学芝加哥分校“UIC动物设施改进补助金”的目标是翻新和扩建动物设施，以满足视觉相关研究中动物使用日益增长的需求，而该机构的集中式动物设施无法满足这一需求。这一目标将通过翻新和增强眼科和视觉科学系的卫星动物设施来实现，以创建进行视觉相关研究所必需的动物饲养环境。具体来说，将重建伊利诺伊州狮子眼科研究所 (LIERI) 的一个 900 平方英尺的房间，以满足《实验动物护理和使用指南》（指南）中关于饲养啮齿类动物的建议。房间将被分为几个隔间，一个光控隔间用于光敏感实验，一个环境控制隔间用于建立干眼病动物模型，一个缺氧隔间用于产生与氧气相关的眼病动物模型。该部门还将集中现有的视觉研究仪器，用于监测和测量邻近动物饲养区的活体动物的视觉功能。拟议的翻修将确保整个校园的动物护理计划继续符合指南的建议，并进一步加强整个计划在住房、护理和兽医监督方面的质量，同时创造一个理想的环境，以促进伊利诺伊大学芝加哥分校的视觉研究。此外，用于视觉研究的集中卫星动物设施将最大限度地减少动物运输以及实验动物和该机构集中动物设施啮齿动物群中饲养的动物的潜在微生物污染。