UCSD Rodent Phenotyping Core

描述（由申请人提供）：在过去的十年中，基于动物的研究的持续增长导致UCSD小鼠数量增加了两倍。啮齿动物表型核心设施最近成立，提供啮齿动物为基础的调查表型分析到一系列关键的生物医学问题正在研究中的加州大学，圣地亚哥。建立这一核心资源的基础是提供关键的表型分析设备，用于分析每天出现的45 000多箱啮齿动物中的任何一箱。由此产生的减少对昂贵的重复空间和资源的需求也是UCSD动物研究计划可持续发展计划的关键组成部分。需要资金购买九个关键表型系统，涵盖代谢、学习、记忆、感觉运动、听觉和神经功能，这些系统将为从神经退行性疾病到内分泌疾病再到遗传性疾病的研究提供新的或更新的功能。我们的具体目标是1）扩大集中啮齿动物表型计划，使关键测试提供给所有UCSD PHS资助的研究人员，和2）现代化集中啮齿动物核心表型能力为UCSD PHS资助的研究人员。由于已经制定了该核心机构的成功操作要求，包括空间、技术专长、可变试验方案的相关住房以及支持管理（包括从其他机构转移动物）的在线信息处理系统，因此所要求的设备将对研究产生直接影响，并迫切需要进行相关的表型分析。

DESCRIPTION (provided by applicant): Continual growth in animal based research has led to a tripling of the UCSD mouse population over the past decade. The Rodent Phenotyping Core facility was recently established to provide phenotypic analysis for rodent-based investigations into a wide array of critical biomedical issues under study at the University of California, San Diego. Making key phenotyping equipment available for analysis of any of the over 45,000 boxes of rodents present on a daily basis was the basis for the establishment of this core resource. The resultant decreased need for costly duplication of space and resources is also a key component to the sustainability plan for the UCSD animal research program. Funding is requested to purchase nine key phenotyping systems encompassing metabolism, learning, memory, sensorimotor, auditory and neurologic functions that will offer new or updated capabilities for the studies ranging from neurodegenerative to endocrine to genetic disorders. Our specific aims are to 1) expand the centralized rodent phenotyping program making key testing available to all UCSD PHS funded researchers, and 2) modernize centralized rodent core phenotyping capabilities for UCSD PHS funded researchers. Because successful operating requirements for this core facility have been worked out including, space, technical expertise, associated housing for variable testing regimens, and online information handling system to support administration including transfer of animals from other facilities, the requested equipment will have an immediate impact on studies with the critical need for associated phenotypic analysis.