UCSD Rodent Phenotyping Core

描述（由申请人提供）：在过去十年中，动物研究的持续增长导致UCSD小鼠数量增加了三倍。最近建立了啮齿动物表型核心设施，为加利福尼亚大学圣地亚哥分校正在研究的一系列关键生物医学问题的啮齿动物调查提供表型分析。提供关键的表型设备，用于分析每天存在的45,000多箱啮齿动物中的任何一种，是建立这一核心资源的基础。由此减少了对昂贵的重复空间和资源的需求，这也是加州大学圣地亚哥分校动物研究项目可持续发展计划的关键组成部分。申请资金用于购买九个关键表型系统，包括代谢、学习、记忆、感觉运动、听觉和神经功能，这些系统将为从神经退行性疾病到内分泌和遗传疾病的研究提供新的或更新的能力。我们的具体目标是1)扩展集中的啮齿动物表型项目，使所有UCSD PHS资助的研究人员都可以进行关键测试；2)为UCSD PHS资助的研究人员现代化集中的啮齿动物核心表型能力。由于该核心设施的成功运行要求已经制定出来，包括空间、技术专长、可变测试方案的相关住房，以及支持管理的在线信息处理系统，包括从其他设施转移动物，所要求的设备将对相关表型分析的迫切需求的研究产生直接影响。

DESCRIPTION (provided by applicant): Continual growth in animal based research has led to a tripling of the UCSD mouse population over the past decade. The Rodent Phenotyping Core facility was recently established to provide phenotypic analysis for rodent-based investigations into a wide array of critical biomedical issues under study at the University of California, San Diego. Making key phenotyping equipment available for analysis of any of the over 45,000 boxes of rodents present on a daily basis was the basis for the establishment of this core resource. The resultant decreased need for costly duplication of space and resources is also a key component to the sustainability plan for the UCSD animal research program. Funding is requested to purchase nine key phenotyping systems encompassing metabolism, learning, memory, sensorimotor, auditory and neurologic functions that will offer new or updated capabilities for the studies ranging from neurodegenerative to endocrine to genetic disorders. Our specific aims are to 1) expand the centralized rodent phenotyping program making key testing available to all UCSD PHS funded researchers, and 2) modernize centralized rodent core phenotyping capabilities for UCSD PHS funded researchers. Because successful operating requirements for this core facility have been worked out including, space, technical expertise, associated housing for variable testing regimens, and online information handling system to support administration including transfer of animals from other facilities, the requested equipment will have an immediate impact on studies with the critical need for associated phenotypic analysis.