Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference 2023.

2023 年约翰霍普金斯大学视网膜变性和视觉电生理学会议。

• 批准号: 10753624
• 负责人: MANDEEP SINGH
• 金额: $ 7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753624
• 关键词: Affect; Agreement; Allogenic; Animal Model; Animals; Artificial Intelligence; Award; Baltimore; Basic Science; Blindness; Cell Therapy; Cells; Clinical; Clinical Research; Clinical Trials; Collaborations; Complement; Consensus; Data; Detection; Developing Countries; Development; Diagnosis; Disease; Disease Progression; Electrophysiology (science); Equity; Ethics; Faculty Workshop; Failure; Fostering; Funding; Gene therapy trial; Genes; Goals; Human; Human Cell Line; Immunosuppression; Individual; Industry; Inherited; International; Knowledge; Laboratories; Laboratory Research; Lead; Learning; Maryland; Microelectrodes; Modality; Molecular; Nanotechnology; Operative Surgical Procedures; Organoids; Outcome Measure; Participant; Pathogenesis; Patients; Perimetry; Persons; Pharmacotherapy; Phase; Phase III Clinical Trials; Phenotype; Protocols documentation; Recommendation; Recurrence; Research; Research Personnel; Research Subjects; Retina; Retinal Degeneration; Retinal Diseases; Retinal Dystrophy; Schedule; Science; Scientist; Series; Serious Adverse Event; Societies; Source; Stem cell transplant; Testing; Therapeutic; Therapeutic Agents; Translational Research; Travel; Treatment Failure; Treatment outcome; Underrepresented Minority; Update; Vision; Visual; Visual impairment; Woman; antioxidant therapy; base editing; career; clinical care; clinical translation; computer studies; design; epidemiology study; equity, diversity, and inclusion; first-in-human; functional outcomes; gene therapy; genome editing; hearing impairment; human subject; implantation; in vitro Model; insight; meetings; multidisciplinary; nanomedicine; neurophysiology; neuroprotection; novel; novel therapeutics; pre-clinical; prevent; programs; reconstruction; retinal progenitor cell; stem cell gene therapy; stem cell therapy; stem cells; success; symposium; therapy development; translational study; treatment strategy

Project Summary/Abstract This application seeks to support three biennial editions of the Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference. These meetings will continuously update early-stage investigators, trainees, clinicians, and scientists on the latest translational and clinical research on Inherited retinal diseases (IRDs). In addition, the conference will address multiple identified gaps in knowledge in interpreting visual function tests, including electrophysiology and microperimetry. The meetings will be held biannually in September in Baltimore, Maryland. The specific aims covered by this conference include 1) understanding the cellular and molecular basis of selected IRDs, 2) reviewing the recommendations from the Society of Clinical Electrophysiology of Vision (ISCEV) regarding visual neurophysiology testing, 3) reviewing the structural and functional outcome measures of IRDs, including those relevant to research subjects with ultra-low vision, 4) analyzing data and results from current treatments in development, especially those in Phase I, II, and III clinical trials and large animal studies, with an emphasis on retinal stem cells and gene therapy, and other treatment modalities, and 5) reviewing aspects relating to equitable access to clinical care and research for IRD patients, and ethical considerations unique to people with vision loss due to IRDs. The requested funds will support the attendance of trainees and early-career investigators, travel awards, and diversity awards to support women, under- represented minorities (URMs), and international participants, including those from developing countries. These meetings will be an ideal opportunity for trainees of diverse backgrounds, early-stage investigators, under- represented minorities, and international trainees to network and learn from leaders in the field of retinal degeneration. In addition, we hope this meeting will encourage multidisciplinary and international collaboration between clinicians and investigators to develop novel therapies and clinical trials end points.

项目总结/摘要 此应用程序旨在支持三个两年一度的约翰霍普金斯视网膜变性和视觉 电生理学会议。这些会议将不断更新早期研究人员、受训人员， 临床医生和科学家关于遗传性视网膜疾病（IRD）的最新转化和临床研究。在 此外，会议将解决在解释视觉功能测试方面的多个已确定的知识差距， 包括电生理学和微视野检查。会议将于9月在巴尔的摩举行， 马里兰州。本次会议的具体目标包括：1）了解细胞和分子 根据选定的IRD，2）审查临床电生理学会的建议， 视觉（ISCEV）关于视觉神经生理学测试，3）审查结构和功能结果 IRD的测量，包括与超低视力研究受试者相关的测量，4）分析数据， 目前正在开发的治疗方法的结果，特别是I期、II期和III期临床试验和大型 动物研究，重点是视网膜干细胞和基因治疗，以及其他治疗方式，以及5） 检讨有关税务局病人公平获得临床护理和研究的事宜，以及 因IRD导致视力丧失的人特有的考虑因素。申请的资金将用于支持出席 培训学员和早期职业调查员，旅行奖和多样性奖，以支持妇女，根据- 代表少数群体（URMs）和国际与会者，包括来自发展中国家的与会者。这些 会议将是一个理想的机会，为学员的不同背景，早期阶段的研究人员， 代表少数民族和国际受训人员建立网络，向视网膜病变领域的领导人学习。 退化此外，我们希望这次会议将鼓励多学科和国际合作 临床医生和研究人员之间的合作，以开发新的治疗方法和临床试验终点。