Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference 2023.

2023 年约翰霍普金斯大学视网膜变性和视觉电生理学会议。

• 批准号: 10753624
• 负责人: MANDEEP SINGH
• 金额: $ 7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753624
• 关键词: Affect; Agreement; Allogenic; Animal Model; Animals; Artificial Intelligence; Award; Baltimore; Basic Science; Blindness; Cell Therapy; Cells; Clinical; Clinical Research; Clinical Trials; Collaborations; Complement; Consensus; Data; Detection; Developing Countries; Development; Diagnosis; Disease; Disease Progression; Electrophysiology (science); Equity; Ethics; Faculty Workshop; Failure; Fostering; Funding; Gene therapy trial; Genes; Goals; Human; Human Cell Line; Immunosuppression; Individual; Industry; Inherited; International; Knowledge; Laboratories; Laboratory Research; Lead; Learning; Maryland; Microelectrodes; Modality; Molecular; Nanotechnology; Operative Surgical Procedures; Organoids; Outcome Measure; Participant; Pathogenesis; Patients; Perimetry; Persons; Pharmacotherapy; Phase; Phase III Clinical Trials; Phenotype; Protocols documentation; Recommendation; Recurrence; Research; Research Personnel; Research Subjects; Retina; Retinal Degeneration; Retinal Diseases; Retinal Dystrophy; Schedule; Science; Scientist; Series; Serious Adverse Event; Societies; Source; Stem cell transplant; Testing; Therapeutic; Therapeutic Agents; Translational Research; Travel; Treatment Failure; Treatment outcome; Underrepresented Minority; Update; Vision; Visual; Visual impairment; Woman; antioxidant therapy; base editing; career; clinical care; clinical translation; computer studies; design; epidemiology study; equity, diversity, and inclusion; first-in-human; functional outcomes; gene therapy; genome editing; hearing impairment; human subject; implantation; in vitro Model; insight; meetings; multidisciplinary; nanomedicine; neurophysiology; neuroprotection; novel; novel therapeutics; pre-clinical; prevent; programs; reconstruction; retinal progenitor cell; stem cell gene therapy; stem cell therapy; stem cells; success; symposium; therapy development; translational study; treatment strategy

Project Summary/Abstract This application seeks to support three biennial editions of the Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference. These meetings will continuously update early-stage investigators, trainees, clinicians, and scientists on the latest translational and clinical research on Inherited retinal diseases (IRDs). In addition, the conference will address multiple identified gaps in knowledge in interpreting visual function tests, including electrophysiology and microperimetry. The meetings will be held biannually in September in Baltimore, Maryland. The specific aims covered by this conference include 1) understanding the cellular and molecular basis of selected IRDs, 2) reviewing the recommendations from the Society of Clinical Electrophysiology of Vision (ISCEV) regarding visual neurophysiology testing, 3) reviewing the structural and functional outcome measures of IRDs, including those relevant to research subjects with ultra-low vision, 4) analyzing data and results from current treatments in development, especially those in Phase I, II, and III clinical trials and large animal studies, with an emphasis on retinal stem cells and gene therapy, and other treatment modalities, and 5) reviewing aspects relating to equitable access to clinical care and research for IRD patients, and ethical considerations unique to people with vision loss due to IRDs. The requested funds will support the attendance of trainees and early-career investigators, travel awards, and diversity awards to support women, under- represented minorities (URMs), and international participants, including those from developing countries. These meetings will be an ideal opportunity for trainees of diverse backgrounds, early-stage investigators, under- represented minorities, and international trainees to network and learn from leaders in the field of retinal degeneration. In addition, we hope this meeting will encourage multidisciplinary and international collaboration between clinicians and investigators to develop novel therapies and clinical trials end points.

项目概要/摘要 该应用程序旨在支持约翰霍普金斯大学视网膜变性和视觉的三个双年版 电生理学会议。这些会议将不断更新早期研究人员、受训人员、 临床医生和科学家了解遗传性视网膜疾病 (IRD) 的最新转化和临床研究。在 此外，会议将解决在解释视功能测试方面多个已知的知识差距， 包括电生理学和微视野测定法。这些会议将于九月在巴尔的摩每两年举行一次， 马里兰州。本次会议涵盖的具体目标包括1）了解细胞和分子 选定 IRD 的基础，2) 审查临床电生理学会的建议 关于视觉神经生理学测试的视觉 (ISCEV)，3) 审查结构和功能结果 IRD 的测量，包括与超低视力研究对象相关的测量，4) 分析数据和 来自当前正在开发的治疗方法的结果，特别是那些处于 I、II 和 III 期临床试验和大型临床试验中的治疗方法 动物研究，重点是视网膜干细胞和基因治疗以及其他治疗方式，5) 审查与 IRD 患者公平获得临床护理和研究有关的方面，以及道德 由于 IRD 导致视力丧失的人所特​​有的考虑因素。请求的资金将支持出席 培训生和早期职业调查员、旅行奖和多样性奖，以支持女性， 代表少数群体（URM）和国际参与者，包括来自发展中国家的参与者。这些 会议对于不同背景的受训者、早期研究人员、低水平研究人员来说将是一个理想的机会 代表少数群体和国际学员与视网膜领域的领导者建立联系并向他们学习 退化。此外，我们希望这次会议能够鼓励多学科和国际合作 临床医生和研究人员之间开发新疗法和临床试验终点。