Pediatric Circulatory Support

儿科循环支持

• 批准号: 7924249
• 负责人: HARVEY S. BOROVETZ, PH.D.
• 金额: $ 29.02万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924249
• 关键词: Pediatric; Circulatory; Support

The PediaFlow consortium is developing a mixed-flow turbodynamic (continuous flow) ventricular assist device utilizing a magnetically levitated impeller capable of producing 0.3-1.5 liters per minute (LPM) of blood flow for supporting infants and small children weighing 3-15 kg up to 6 months with minimal anticoagulation requirement and optimal biocompatibility. Over 20 design variations were initially considered, with three pump topologies selected for further design refinement and evaluation. The three designs, two centrifugal and one mixed-flow pumps, were judged based on a multi-component objective function which factored several criteria including anatomic fit, estimated biocompatibility, heat generation and transfer, magnetically levitated suspension robustness, and manufacturability. This evaluation led to selection of the mixed-flow configuration. The design was improved using computational fluid dynamics to minimize flow-induced blood damage via modification of the geometry of the predicted blood flow path. The housing was modified to improve surgical fixation. A transparent replica of the blood flow path was built to perform validation of the computer predictions by flow visualization analyses. Other ongoing efforts are focused on controller development, materials selection, biocompatible coating application, nanotechnology based infection control, cannula design, and overall assessment of hemodynamic performance and cellular biocompatibility. Fabrication and assembly of initial components (Figures 1, 2) produced a finalized first generation pump design (PediaFlow¿ GEN1) that is 51 mm in length and 28 mm in diameter with 5 mm diameter inlet and outlet conduits. The mass is approximately 100 grams. At a nominal flow rate of 0.5 LPM, generating 110 mm Hg pressure rise, and 8,000 RPM rotor speed, the shaft power is approximately 0.9 Watts leading to an overall efficiency estimate of 11%.

PediaFlow联盟正在开发一种混合流涡轮动力（连续流）心室辅助装置，该装置利用磁悬浮叶轮，能够产生每分钟0.3-1.5升（LPM）的血流量，用于支持体重3-15公斤的婴儿和幼儿，最多6个月，抗凝需求最小，生物相容性最佳。