Oleoyl-ACP-hydrolase as an early predictive biomarker for severe and fatal influenza

每年有数百万人因严重流感而住院，约50万人死亡，但导致疾病的潜在机制仍未完全了解。我们已经确定了一种参与脂肪酸代谢的酶的关键作用，这种酶在死于流感的患者中急剧升高，因此是致命结果的预测因子。这项研究旨在研究这种酶如何影响感染和损害免疫反应，从而导致严重的呼吸道病毒疾病。

Millions are hospitalized with severe influenza disease and ~500K die annually but the underlying mechanisms that drive disease are still not fully understood. We have identified a key role for an enzyme involved in fatty acid metabolism, which is profoundly elevated in patients who succumb to influenza and is thus a predictor for fatal outcomes. This research aims to investigate how this enzyme affects infection and impairs immune responses to drive severe respiratory viral disease.