Becton Dickinson LSR II

贝克顿·迪金森 LSR II

基本信息

  • 批准号:
    7594950
  • 负责人:
  • 金额:
    $ 37.86万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-04-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The purpose of this NCRR Shared Instrument Grant application is to secure funding to purchase an LSRII polychromatic analytical flow cytometer for the Flow Cytometry Core Facility (FCCF) at the University of Virginia School of Medicine. The FCCF is a very heavily used core facility at the University of Virginia and provides flow cytometry related services on a fee for service basis to the University community in general and particularly to NIH funded investigators in the School of Medicine. The FCCF currently serves over 200 investigators from the laboratories of 98 PIs from 27 different departments. Twenty seven of these PIs use the FCCF for polychromatic (>5 color) flow cytometry (PFC) experiments. The FCCF has a single Cyan ADP nine color instrument, which is currently run at >78% capacity and is the only analytical flow cytometer capable of more than 6 colors and a violet laser within 100 miles of UVA. The use of PFC has steadily increased since 2004 and has exploded over the past year. Increased use of PFC is the result of educational programs instituted by the FCCF that have greatly increased the awareness as well as the current trend in many scientific fields as evidenced in the literature. In addition, many other academic institutions with which our investigators have active collaborations have access to instrumentation capable of more than five colors. The lack of backup instrumentation and the technical limitation of only nine colors have prevented the FCCF from expanding to meet the needs of the UVA research community. Purchase and implementation of the LSRII will 1) allow the FCCF to meet current demand for PFC, 2) meet anticipated requirements for increased capacity in the near future, 3) provide back up capability when the current machine needs repairs and 4) increase services available to the UVA research community by increasing the number of parameters available for analysis. Public Health Relevance: PFC is a technique of fundamental importance in current biomedical research, crosses many disciplines and is used by individuals doing basic, clinical and translational research working on problems related to cancer, infectious disease, aging, immunology, neuroscience and cardiovascular disease among many others. The increased demand for PFC services at UVA has greatly outstripped the capacity and capability of existing instrumentation and has become a serious bottleneck to completing a wide variety of research projects funded in a large part by the NIH. Purchase of an LSRII will relieve this bottleneck and extend our capabilities.
描述(由申请人提供):本NCRR共享仪器补助申请的目的是确保资金,以购买LSRII多色分析流式细胞仪的流式细胞术核心设施(FCCF)在弗吉尼亚大学医学院。FCCF是弗吉尼亚大学一个使用非常频繁的核心设施,并以服务费为基础向大学社区提供流式细胞术相关服务,特别是向NIH资助的医学院研究人员提供服务。该基金目前为来自27个不同部门的98名主要研究人员的实验室的200多名研究人员提供服务。其中27名PI使用FCCF进行多色(>5色)流式细胞术(PFC)实验。FCCF有一台青色ADP九色仪器,目前运行能力超过78%,是唯一一台能够在UVA 100英里范围内检测6种以上颜色和紫色激光的分析流式细胞仪。自2004年以来,全氟化学品的使用稳步增加,并在去年出现爆炸式增长。全氟化学品使用的增加是FCCF制定的教育计划的结果,这些计划极大地提高了人们的认识,并在文献中证明了许多科学领域的当前趋势。此外,与我们的研究人员积极合作的许多其他学术机构可以使用超过五种颜色的仪器。由于缺乏后备仪器和只有九种颜色的技术限制,FCCF无法扩展以满足UVA研究社区的需求。LSRII的购买和实施将1)使FCCF能够满足当前对PFC的需求,2)满足不久的将来增加容量的预期要求,3)在当前机器需要维修时提供备份能力,以及4)通过增加可用于分析的参数数量来增加UVA研究社区的服务。公共卫生相关性:PFC是当前生物医学研究中具有根本重要性的技术,跨越许多学科,并被个人用于进行基础,临床和转化研究,研究与癌症,传染病,衰老,免疫学,神经科学和心血管疾病等相关的问题。UVA对PFC服务需求的增加已经大大超过了现有仪器的容量和能力,并已成为完成大量由NIH资助的各种研究项目的严重瓶颈。购买LSRII将缓解这一瓶颈并扩展我们的能力。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Timothy P. Bender其他文献

Differentiation of mouse erythroleukemia cells is blocked by late up-regulation of a c-myb transgene
c-myb 转基因的晚期上调阻碍了小鼠红白血病细胞的分化
  • DOI:
    10.1128/mcb.10.2.705-710.1990
  • 发表时间:
    1990
  • 期刊:
  • 影响因子:
    5.3
  • 作者:
    Diana McCLINTON;Jeannine Stafford;Leslie;Brents;Timothy P. Bender;W. Michael;'. Kuehl
  • 通讯作者:
    '. Kuehl
Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell line
转染的人 c-myc 癌基因的表达抑制小鼠红白血病细胞系的分化
  • DOI:
    10.1038/322748a0
  • 发表时间:
    1986-08-21
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Ethan Dmitrovsky;W. Michael Kuehl;Gregory F. Hollis;Ilan R. Kirsch;Timothy P. Bender;Shoshana Segal
  • 通讯作者:
    Shoshana Segal
Considerations for the physical vapor deposition of high molar mass organic compounds
  • DOI:
    10.1016/j.vacuum.2014.05.023
  • 发表时间:
    2014-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jeffrey S. Castrucci;Jeremy D. Dang;Brett A. Kamino;Andrew Campbell;David Pitts;Zheng-Hong Lu;Timothy P. Bender
  • 通讯作者:
    Timothy P. Bender
Redox behaviour of boron subphthalocyanine carbon nanotube composites
  • DOI:
    10.1016/j.nxmate.2024.100163
  • 发表时间:
    2024-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Raunaq Bagchi;Erika Remigio;Dian Yu;Nina F. Farac;Averey Kudlow;Jane Howe;Timothy P. Bender;Keryn Lian
  • 通讯作者:
    Keryn Lian

Timothy P. Bender的其他文献

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{{ truncateString('Timothy P. Bender', 18)}}的其他基金

Signaling and Transcriptional Control of T Follicular Helper Cells and RBC Alloimmunization
滤泡辅助 T 细胞和红细胞同种免疫的信号传导和转录控制
  • 批准号:
    9753378
  • 财政年份:
    2018
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb in CD4 T cells is crucial for recall antibody responses
CD4 T 细胞中的 c-Myb 对于记忆抗体反应至关重要
  • 批准号:
    8820986
  • 财政年份:
    2014
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb controls survival, proliferation and differentiation during B-lymphopoiesis
c-Myb 控制 B 淋巴细胞生成过程中的存活、增殖和分化
  • 批准号:
    8478146
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb fusion proteins in Adenoid Cystic Carcinoma
腺样囊性癌中的 c-Myb 融合蛋白
  • 批准号:
    8303226
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb controls survival, proliferation and differentiation during B-lymphopoiesis
c-Myb 控制 B 淋巴细胞生成过程中的存活、增殖和分化
  • 批准号:
    8665994
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb controls survival, proliferation and differentiation during B-lymphopoiesis
c-Myb 控制 B 淋巴细胞生成过程中的存活、增殖和分化
  • 批准号:
    8162936
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
ImageSteamX
图像SteamX
  • 批准号:
    8052019
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb controls survival, proliferation and differentiation during B-lymphopoiesis
c-Myb 控制 B 淋巴细胞生成过程中的存活、增殖和分化
  • 批准号:
    8325520
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
c-Myb fusion proteins in Adenoid Cystic Carcinoma
腺样囊性癌中的 c-Myb 融合蛋白
  • 批准号:
    8174241
  • 财政年份:
    2011
  • 资助金额:
    $ 37.86万
  • 项目类别:
iCyt Reflection Cell Sorter
iCyt 反射细胞分选仪
  • 批准号:
    7389042
  • 财政年份:
    2007
  • 资助金额:
    $ 37.86万
  • 项目类别:
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