Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
基本信息
- 批准号:7842122
- 负责人:
- 金额:$ 11.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-15 至 2010-07-01
- 项目状态:已结题
- 来源:
- 关键词:Abdominal Aortic AneurysmAccountingAgeAge-YearsAndrogen AntagonistsAndrogen ReceptorAndrogensAneurysmAortaAortic AneurysmAromatase InhibitionAutomobile DrivingBicalutamideBone Marrow TransplantationCCL2 geneCXCL2 geneCaliberCastrationCaucasiansCaucasoid RaceCause of DeathCellsCessation of lifeChimera organismCollagenComplexDevelopmentDiseaseDonor personElastinEnvironmentEnzymesEquilibriumEstradiolEstrogensExtracellular Matrix ProteinsFemaleFunctional disorderGelatinase BGenderGender RoleGeneticGonadal HormonesHistologicHormonalHormone ReceptorHormonesHumanHypertensionIL8 geneIncidenceInfiltrationInflammatoryInflammatory ResponseInvestigationKnockout MiceLetrozoleLeukocyte TraffickingLeukocytesLifeMMP2 geneMeasurementMediatingMediator of activation proteinMedicalModelingMusOperative Surgical ProceduresOrgan TransplantationPathogenesisPatientsPatternPrevalencePrevention approachProductionRegulationRelative (related person)Risk FactorsRoleSamplingSecondary toSelective Estrogen Receptor ModulatorsSex CharacteristicsSmoking HistorySmooth Muscle MyocytesSupplementationTamoxifenTestingTestosteroneTissuesTransplantationTunica AdventitiaWomanbasechemokinemacrophagemalemenneutrophilreceptorrepairedresearch studytranslational approach
项目摘要
Abdominal aortic aneurysms (AAAs) comprise the 10th leading cause of death in Caucasian males 65-74
years of age and accounted for nearly 16,000 deaths overall in the year 2000. Understanding the
pathophysiology of AAAs is an important undertaking. Clinically, multiple risk factors are associated with the
development of AAAs, including increasing age, positive smoking history, and hypertension. Male gender is
also a well-established risk factor for the development of an AAA with a 4:1 male to female ratio. The reason
for this gender disparity is unknown. The pathogenesis of AAAs formation is complex and multifactorial.
Histologically, AAAs are characterized by early chemokine driven leukocyte infiltration into the aortic wall
with subsequent destruction of elastin and collagen in the media and adventitia by excessive local production
of matrix degrading enzymes, and smooth muscle cell loss with thinning of the aortic wall. At present, there
are no medical therapies available to treat patients with aortic aneurysms, using only the crude
measurement of aortic diameter as a threshold for which patients must undergo life-threatening and costly
surgery, either open or endovascularly. Therefore, defining the early mechanisms underlying gender-related
differences in AAA formation are critical and will be the focus of the present investigation.
Understanding differences in disease patterns based on gender may allow us to develop new translational
approaches to the prevention and treatment of patients with aortic aneurysms. Overall hypothesis: Gender-
related differences in aortic aneurysm formation are mediated by the hormonal (androgen: estrogen ratio)
regulation of leukocyte trafficking into the aortic wall. Specific Aim 1. To define the mechanism by which early
inflammatory cell recruitment is accelerated in males during AAA formation. Studies will test the hypothesis
that increased incidence of AAAs in males is secondary to increased recruitment of leukocytes into the aortic
wall driven by an excess of androgens relative to estrogens. Specific Aim 2. To demonstrate that gonadal
hormones can be used to modulate the inflammatory response accompanying AAA formation. Studies will
test the hypothesis that altering the androgen: estrogen environment can dictate the prevalence of aneurysm
formation by altering the forementioned specific soluble mediator dependent leukocyte trafficking, ultimately
driving the balance of matrix degradation and repair toward aneurysm formation.
腹主动脉瘤(AAAs)是65-74岁白人男性死亡的第十大原因
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gilbert Rivers Upchurch其他文献
Aromatase Deletion Accelerates Female Experimental Abdominal Aortic Aneurysm Formation
- DOI:
10.1016/j.jvs.2013.07.042 - 发表时间:
2013-10-01 - 期刊:
- 影响因子:
- 作者:
William Forrest Johnston;Gang Su;Morgan Salmon;Guanyi Lu;Emilie F. Rissman;Gorav Ailawadi;Gilbert Rivers Upchurch - 通讯作者:
Gilbert Rivers Upchurch
Artificial Intelligence for Predicting Complication with Live-Streaming Data: Prospective MySurgeryRisk Validation
- DOI:
10.1016/j.jamcollsurg.2020.07.256 - 发表时间:
2020-10-01 - 期刊:
- 影响因子:
- 作者:
Tyler John Loftus;Chris Giordano;Gilbert Rivers Upchurch;Azra Bihorac - 通讯作者:
Azra Bihorac
Gilbert Rivers Upchurch的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gilbert Rivers Upchurch', 18)}}的其他基金
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
- 批准号:
9700321 - 财政年份:2014
- 资助金额:
$ 11.96万 - 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
- 批准号:
9111039 - 财政年份:2014
- 资助金额:
$ 11.96万 - 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
- 批准号:
9321216 - 财政年份:2014
- 资助金额:
$ 11.96万 - 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
- 批准号:
8765843 - 财政年份:2014
- 资助金额:
$ 11.96万 - 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
- 批准号:
7842508 - 财政年份:2007
- 资助金额:
$ 11.96万 - 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
- 批准号:
8179083 - 财政年份:2007
- 资助金额:
$ 11.96万 - 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
- 批准号:
7632241 - 财政年份:2007
- 资助金额:
$ 11.96万 - 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
- 批准号:
8167383 - 财政年份:2007
- 资助金额:
$ 11.96万 - 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
- 批准号:
7477775 - 财政年份:2007
- 资助金额:
$ 11.96万 - 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
- 批准号:
8918723 - 财政年份:2007
- 资助金额:
$ 11.96万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 11.96万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别:
Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 11.96万 - 项目类别: