Gender Differences in Experimental Aortic Aneurysms

实验性主动脉瘤的性别差异

基本信息

项目摘要

Abdominal aortic aneurysms (AAAs) comprise the 10th leading cause of death in Caucasian males 65-74 years of age and accounted for nearly 16,000 deaths overall in the year 2000. Understanding the pathophysiology of AAAs is an important undertaking. Clinically, multiple risk factors are associated with the development of AAAs, including increasing age, positive smoking history, and hypertension. Male gender is also a well-established risk factor for the development of an AAA with a 4:1 male to female ratio. The reason for this gender disparity is unknown. The pathogenesis of AAAs formation is complex and multifactorial. Histologically, AAAs are characterized by early chemokine driven leukocyte infiltration into the aortic wall with subsequent destruction of elastin and collagen in the media and adventitia by excessive local production of matrix degrading enzymes, and smooth muscle cell loss with thinning of the aortic wall. At present, there are no medical therapies available to treat patients with aortic aneurysms, using only the crude measurement of aortic diameter as a threshold for which patients must undergo life-threatening and costly surgery, either open or endovascularly. Therefore, defining the early mechanisms underlying gender-related differences in AAA formation are critical and will be the focus of the present investigation. Understanding differences in disease patterns based on gender may allow us to develop new translational approaches to the prevention and treatment of patients with aortic aneurysms. Overall hypothesis: Gender- related differences in aortic aneurysm formation are mediated by the hormonal (androgen: estrogen ratio) regulation of leukocyte trafficking into the aortic wall. Specific Aim 1. To define the mechanism by which early inflammatory cell recruitment is accelerated in males during AAA formation. Studies will test the hypothesis that increased incidence of AAAs in males is secondary to increased recruitment of leukocytes into the aortic wall driven by an excess of androgens relative to estrogens. Specific Aim 2. To demonstrate that gonadal hormones can be used to modulate the inflammatory response accompanying AAA formation. Studies will test the hypothesis that altering the androgen: estrogen environment can dictate the prevalence of aneurysm formation by altering the forementioned specific soluble mediator dependent leukocyte trafficking, ultimately driving the balance of matrix degradation and repair toward aneurysm formation.
腹主动脉瘤(AAAs)是65-74岁白人男性死亡的第十大原因

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Gilbert Rivers Upchurch其他文献

Aromatase Deletion Accelerates Female Experimental Abdominal Aortic Aneurysm Formation
  • DOI:
    10.1016/j.jvs.2013.07.042
  • 发表时间:
    2013-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    William Forrest Johnston;Gang Su;Morgan Salmon;Guanyi Lu;Emilie F. Rissman;Gorav Ailawadi;Gilbert Rivers Upchurch
  • 通讯作者:
    Gilbert Rivers Upchurch
Artificial Intelligence for Predicting Complication with Live-Streaming Data: Prospective MySurgeryRisk Validation
  • DOI:
    10.1016/j.jamcollsurg.2020.07.256
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Tyler John Loftus;Chris Giordano;Gilbert Rivers Upchurch;Azra Bihorac
  • 通讯作者:
    Azra Bihorac

Gilbert Rivers Upchurch的其他文献

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{{ truncateString('Gilbert Rivers Upchurch', 18)}}的其他基金

Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    9700321
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    9111039
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    9321216
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    8765843
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    7842508
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    8179083
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    7632241
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    8167383
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    7477775
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    8918723
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:

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