Gender Differences in Experimental Aortic Aneurysms

实验性主动脉瘤的性别差异

基本信息

项目摘要

Abdominal aortic aneurysms (AAAs) comprise the 10th leading cause of death in Caucasian males 65-74 years of age and accounted for nearly 16,000 deaths overall in the year 2000. Understanding the pathophysiology of AAAs is an important undertaking. Clinically, multiple risk factors are associated with the development of AAAs, including increasing age, positive smoking history, and hypertension. Male gender is also a well-established risk factor for the development of an AAA with a 4:1 male to female ratio. The reason for this gender disparity is unknown. The pathogenesis of AAAs formation is complex and multifactorial. Histologically, AAAs are characterized by early chemokine driven leukocyte infiltration into the aortic wall with subsequent destruction of elastin and collagen in the media and adventitia by excessive local production of matrix degrading enzymes, and smooth muscle cell loss with thinning of the aortic wall. At present, there are no medical therapies available to treat patients with aortic aneurysms, using only the crude measurement of aortic diameter as a threshold for which patients must undergo life-threatening and costly surgery, either open or endovascularly. Therefore, defining the early mechanisms underlying gender-related differences in AAA formation are critical and will be the focus of the present investigation. Understanding differences in disease patterns based on gender may allow us to develop new translational approaches to the prevention and treatment of patients with aortic aneurysms. Overall hypothesis: Gender- related differences in aortic aneurysm formation are mediated by the hormonal (androgen: estrogen ratio) regulation of leukocyte trafficking into the aortic wall. Specific Aim 1. To define the mechanism by which early inflammatory cell recruitment is accelerated in males during AAA formation. Studies will test the hypothesis that increased incidence of AAAs in males is secondary to increased recruitment of leukocytes into the aortic wall driven by an excess of androgens relative to estrogens. Specific Aim 2. To demonstrate that gonadal hormones can be used to modulate the inflammatory response accompanying AAA formation. Studies will test the hypothesis that altering the androgen: estrogen environment can dictate the prevalence of aneurysm formation by altering the forementioned specific soluble mediator dependent leukocyte trafficking, ultimately driving the balance of matrix degradation and repair toward aneurysm formation.
在65-74岁的高加索男性中,腹主动脉瘤(AAA)是第十大致死原因。 2000年,死亡总人数接近16,000人。了解 腹主动脉瘤的病理生理学研究是一项重要的工作。临床上,多种危险因素与 AAA的发展,包括年龄增加、阳性吸烟史和高血压。男性性别是 这也是患AAA的公认风险因素,男女比例为4:1。原因 因为这种性别差异是未知的。AAAs的形成机制是复杂的、多因素的。 组织学上,腹主动脉硬化的特征是早期趋化因子驱动的白细胞渗入主动脉壁。 随后过度的局部生产破坏了中膜和外膜中的弹性蛋白和胶原 基质降解酶的作用,以及随着主动脉壁变薄而导致的平滑肌细胞丢失。目前,有 是否没有药物疗法可用于治疗主动脉瘤患者,仅使用粗略的 测量主动脉直径作为患者必须接受危及生命和代价高昂的门槛 手术,无论是开放的还是血管内的。因此,界定与性别有关的早期机制 AAA形成的差异是至关重要的,也将是目前研究的重点。 了解基于性别的疾病模式的差异可能会让我们开发出新的翻译 主动脉瘤患者的防治方法。总体假设:性别-- 主动脉瘤形成的相关差异是由激素(雄激素/雌激素比率)调节的。 白细胞进入主动脉壁的调节。具体目标1.确定早期治疗的机制 在AAA形成期间,男性的炎性细胞募集速度加快。研究将检验这一假设 男性AAA发病率的增加是由于白细胞向主动脉中募集的增加所致 由雄激素相对于雌激素的过量所驱动的壁。具体目标2.为了证明性腺 激素可以用来调节伴随AAA形成的炎症反应。研究将会 验证改变雄激素的假设:雌激素环境可以决定动脉瘤的流行程度 最终通过改变上述特定的可溶性介质依赖的白细胞运输而形成 推动基质降解和修复之间的平衡,走向动脉瘤的形成。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Gilbert Rivers Upchurch其他文献

Aromatase Deletion Accelerates Female Experimental Abdominal Aortic Aneurysm Formation
  • DOI:
    10.1016/j.jvs.2013.07.042
  • 发表时间:
    2013-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    William Forrest Johnston;Gang Su;Morgan Salmon;Guanyi Lu;Emilie F. Rissman;Gorav Ailawadi;Gilbert Rivers Upchurch
  • 通讯作者:
    Gilbert Rivers Upchurch
Artificial Intelligence for Predicting Complication with Live-Streaming Data: Prospective MySurgeryRisk Validation
  • DOI:
    10.1016/j.jamcollsurg.2020.07.256
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Tyler John Loftus;Chris Giordano;Gilbert Rivers Upchurch;Azra Bihorac
  • 通讯作者:
    Azra Bihorac

Gilbert Rivers Upchurch的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Gilbert Rivers Upchurch', 18)}}的其他基金

Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    9700321
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    9111039
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    9321216
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Role of Neutrophil Extracellular Traps in AAA Pathogenesis
中性粒细胞胞外陷阱在 AAA 发病机制中的作用
  • 批准号:
    8765843
  • 财政年份:
    2014
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    7842508
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    8179083
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    7632241
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    8167383
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    7477775
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:
Gender Differences in Experimental Aortic Aneurysms
实验性主动脉瘤的性别差异
  • 批准号:
    8918723
  • 财政年份:
    2007
  • 资助金额:
    $ 11.96万
  • 项目类别:

相似海外基金

Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
  • 批准号:
    10100360
  • 财政年份:
    2024
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
  • 批准号:
    24K04974
  • 财政年份:
    2024
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
  • 批准号:
    23K01686
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
  • 批准号:
    23K01692
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
  • 批准号:
    23K01695
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
  • 批准号:
    23K01713
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
  • 批准号:
    2312319
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
  • 批准号:
    23K01715
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
  • 批准号:
    10585388
  • 财政年份:
    2023
  • 资助金额:
    $ 11.96万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了