Obesity Effects on Pharyngeal Airway Mechanics by MRI
通过 MRI 观察肥胖对咽部气道力学的影响
基本信息
- 批准号:7842026
- 负责人:
- 金额:$ 22.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAnimalsAnteriorAreaBody fatBody mass indexCaliberConfounding Factors (Epidemiology)DataData AnalysesDepositionDietDilatorDimensionsEffectivenessElectric StimulationFatty acid glycerol estersFunctional disorderHumanHyoid bone structureImageInterventionKnowledgeLateralLengthMagnetic Resonance ImagingMeasurementMeasuresMechanicsMedialMediatingMediator of activation proteinModelingMotionMuscleMuscle TonusNerveObesityObstructive Sleep ApneaPatientsPennsylvaniaPharyngeal structurePhysiologicalPositioning AttributePropertyRattusResearch PersonnelRespiration DisordersRiskSecondary toShapesSleepSoft PalateStimulusTechniquesTestingThickTissuesTongueUniversitiesZucker Ratsfeedinggenetic variantinnovationinsightleptin receptornovelpharynx musclepressureprogramssealsubcutaneoustongue volume
项目摘要
Obesity is the most important predictor for obstructive sleep apnea. Although we know that obesity is assoc-
iated with a decrease in pharyngeal airway size and an increase in pharyngeal airway collapsibility, we have
almost no understanding of how obesity alters the mechanical properties of pharyngeal wall tissues to effect
these changes. The PI has developed a novel application of MRI with tissue motion tracking (spatial modul-
ation of magnetization, or SPAMM¿) to examine the relationships between regional changes in pharyngeal
airway size and pharyngeal wall tissue motion in anesthetized rats. Using this innovative technique, we will
determine the effects of obesity on pharyngeal mechanics by studying three groups of Zucker rats with
different degrees of body fat: lean, obese, and even more obese rats fed a high-fat diet. Our global hypo-
thesis is that obesity compromises pharyngeal airway patency through airway narrowing, increased airway
collapsibility, and less effective muscle mechanics. Aim 1 is to determine 1) whether pharyngeal airway
compliance and closing pressure progressively increase across age-matched Zucker rats in the order: lean
< obese < fat-augmented obese rats, and 2) whether these findings are directly related to the amount of
pharyngeal fat. Aim 2 is to determine changes in pharyngeal wall tissue motion for increasingly negative
airway pressure up to induced airway collapse. MRI with SPAMM will be performed during application of
subatmospheric pressure to the isolated, sealed upper aiway to test 1) whether airway collapse is primarily
due to displacement of the anterior pharyngeal wall into the airway, and 2) whether, for a given pharyngeal
region, the relationship between pharyngeal wall tissue motion and airway pressure decrements is progress-
ively increased across age-matched Zucker rats in the order: lean < obese < fat-augmented obese rats. Aim
3 is to determine pharyngeal wall tissue motion in the 3 groups of Zucker rats during electrical activation of
tongue protrudor and retractor muscles. The results will determine whether the relationship between wall
tissue displacement and increase in airway size over a range of stimulus intensities is progressively reduced
across age-matched Zucker rats in the order: lean > obese > fat augmented obese. The proposed studies
will provide new information on how obesity affects pharyngeal mechanics and increase our understanding
of why obese patients are predisposed to pharyngeal airway collapse during sleep.
肥胖是阻塞性睡眠呼吸暂停最重要的预测因素。虽然我们知道肥胖是有关联的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL J BRENNICK其他文献
MICHAEL J BRENNICK的其他文献
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{{ truncateString('MICHAEL J BRENNICK', 18)}}的其他基金
Obesity Effects on Pharyngeal Airway Mechanics by MRI
通过 MRI 观察肥胖对咽部气道力学的影响
- 批准号:
7212569 - 财政年份:2007
- 资助金额:
$ 22.35万 - 项目类别:
Obesity Effects on Pharyngeal Airway Mechanics by MRI
通过 MRI 观察肥胖对咽部气道力学的影响
- 批准号:
7352793 - 财政年份:2007
- 资助金额:
$ 22.35万 - 项目类别:
Obesity Effects on Pharyngeal Airway Mechanics by MRI
通过 MRI 观察肥胖对咽部气道力学的影响
- 批准号:
7751311 - 财政年份:2007
- 资助金额:
$ 22.35万 - 项目类别:
Obesity Effects on Pharyngeal Airway Mechanics by MRI
通过 MRI 观察肥胖对咽部气道力学的影响
- 批准号:
7540408 - 财政年份:2007
- 资助金额:
$ 22.35万 - 项目类别:
Pharyngeal mechanics by tagged MRI in a Zucker rat model
Zucker 大鼠模型中通过标记 MRI 进行咽部力学研究
- 批准号:
6806486 - 财政年份:2003
- 资助金额:
$ 22.35万 - 项目类别:
Pharyngeal mechanics by tagged MRI in a Zucker rat model
Zucker 大鼠模型中通过标记 MRI 进行咽部力学研究
- 批准号:
6708495 - 财政年份:2003
- 资助金额:
$ 22.35万 - 项目类别:
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