Trauma and Inflammation Research Training

创伤和炎症研究培训

• 批准号: 7905027
• 负责人: IRSHAD H CHAUDRY
• 金额: $ 4.01万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-05 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905027
• 关键词: Inflammation; Research Training; Trauma

DESCRIPTION (provided by applicant): The primary goal of this training program is to recruit and train promising young investigators with a commitment to trauma and inflammation research and to promote their development as clinicians / scientists capable of performing independent and productive research. A structured and integrated research training program in trauma-inflammation biology, currently used at the University of Alabama at Birmingham (UAB), will continue to be used. The Center for Surgical Research and the Department of Surgery including Trauma/Burns and Surgical Critical Care, Neurosurgery, Orthopedic Surgery, Chemoprevention Center, Islet Transplant Center, and Departments of Anesthesiology, Cell Biology, Medicine, Microbiology, Pathology, Neuroscience, Physiology and Biophysics at UAB continue to be in a unique position to commit to this program because of the presence of (1) an outstanding multidisciplinary basic and clinical faculty with impeccable credentials as researchers and mentors and (2) the existence of a Level I Trauma Center, Critical Care and Burn Centers and a hospital with 80 operating rooms. These features provide a focal point for the generation of hypothesis-driven research projects that can be developed in the basic science laboratories associated with this program, and also the potential benefit of translating laboratory research to the bedside. One of the residents who trained with us at UAB on another training grant (because he started before the T32 was awarded to us) will be doing a Clinical Trauma Fellowship for the years 2005-2006. After the completion of that fellowship, he will be joining the faculty at UAB and continue to perform epidemiological and prospective clinical studies, thus fulfilling one of the roadmaps that NIH has proposed for translational research. One of the major features of this training program is the inclusion of the basic science and the clinical coordinators as well as two mentors (a PhD and an MD) for each of the trainees. We hope to offer training opportunities to four candidates each year. In addition to MDs, the training will be offered to PhDs as well as DVMs. The trainees who have completed two or three years of clinical training prior to entering this program are expected to complete the clinical training subsequently. Moreover, some outstanding potential candidates who have already completed their clinical training may seek entrance to this training program. The overall direction of this Trauma-Inflammation Research Training program will be the responsibility of the Program Director and the Executive Committee. Candidates for the program will be recruited nationally and from various Departments of UAB School of Medicine. Applications from women and underrepresented minorities will be strongly solicited. We anticipate that after the completion of the two-year training, trainees will be better prepared with expertise and knowledge to pursue meaningful academic careers in trauma and inflammation disciplines.

描述（由申请人提供）：该培训计划的主要目标是招募和培训有前途的年轻研究人员，致力于创伤和炎症研究，并促进他们发展为能够进行独立和富有成效的研究的临床医生/科学家。目前在伯明翰的亚拉巴马大学（UAB）使用的创伤-炎症生物学结构化和综合研究培训方案将继续使用。外科研究中心和外科部门，包括创伤/烧伤和外科重症监护，神经外科，骨科手术，化学预防中心，胰岛移植中心，以及麻醉学，细胞生物学，医学，微生物学，病理学，神经科学，生理学和生物物理学在UAB继续在一个独特的位置，致力于这一计划，因为存在（1）一个优秀的多学科基础和临床教师与无可挑剔的凭据，作为研究人员和导师和（2）一级创伤中心，重症监护和烧伤中心和医院的存在与80个手术室。这些功能为生成假设驱动的研究项目提供了一个焦点，这些项目可以在与该计划相关的基础科学实验室中开发，并且还可以将实验室研究转化为床边研究的潜在好处。其中一位在UAB接受另一项培训补助金培训的住院医生（因为他在T32授予我们之前就开始了）将在2005-2006年获得临床创伤奖学金。完成该奖学金后，他将加入UAB的教师队伍，继续进行流行病学和前瞻性临床研究，从而实现NIH为转化研究提出的路线图之一。该培训计划的主要特点之一是包括基础科学和临床协调员以及每个学员的两名导师（博士和医学博士）。我们希望每年为四名候选人提供培训机会。除了医学博士，培训将提供给博士以及DVM。在进入本计划之前已完成两三年临床培训的学员预计将在随后完成临床培训。此外，一些已经完成临床培训的优秀潜在候选人可能会寻求进入该培训计划。该创伤炎症研究培训计划的总体方向将由计划主任和执行委员会负责。该计划的候选人将在全国范围内招募，并从UAB医学院的各个部门。将大力征求妇女和代表性不足的少数民族的申请。我们预计，在完成为期两年的培训后，学员将获得更好的专业知识和知识，以便在创伤和炎症学科从事有意义的学术事业。

项目成果

Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction.

亚硝酸钠疗法通过还原亚硝酸盐来减弱 HBOC-201 的高血压作用。

• DOI: 10.1042/bj20090735
• 发表时间: 2009
• 期刊: The Biochemical journal
• 作者: Rodriguez,Cilina;Vitturi,DarioA;He,Jin;Vandromme,Marianne;Brandon,Angela;Hutchings,Anne;Rue3rd,LoringW;Kerby,JeffreyD;Patel,RakeshP
• 通讯作者: Patel,RakeshP

Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human.

• DOI: 10.1002/pmic.201100663
• 发表时间: 2012-11
• 期刊: PROTEOMICS
• 影响因子: 3.4
• 作者: Kojima, Kyoko;Bowersock, Gregory J.;Kojima, Chinatsu;Klug, Christopher A.;Grizzle, William E.;Mobley, James A.
• 通讯作者: Mobley, James A.