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Animal Model Studies of ANCA Disease Pathogenesis and its Modifiers

Animal Model Studies of ANCA Disease Pathogenesis and its Modifiers
ANCA 疾病发病机制及其调节因素的动物模型研究
批准号：
8032817
负责人：
J. CHARLES JENNETTE
金额：
$31.43万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8032817
关键词：
AddressAlternative Complement PathwayAnimal ModelAnimalsAntibodiesAntigensAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune ProcessBloodBlood VesselsBone MarrowC5a anaphylatoxin receptorCellsClinical TrialsComplementComplement 5aComplement ActivationDiagnosisDiseaseEnd stage renal failureEpitopesEvaluationEventFutureGene ExpressionGenerationsGenesGeneticGenetic ResearchGenetically Engineered MouseGenomicsGlomerulonephritisGoalsHumanImmune responseImmunizationImmunoglobulin GImmunologicsInflammationInflammatoryInjection of therapeutic agentInvestigationKidneyKidney DiseasesKidney GlomerulusKnowledgeLeukocytesMediatingMembrane ProteinsMethodsModelingMouse StrainsMusOrganOutcomePRTN3 genePathogenesisPatientsPeptidesPeroxidasesProcessProteinase 3ProteinsRapidly Progressive GlomerulonephritisRecombinantsResearchRoleSeveritiesSeverity of illnessTestingTo autoantigenTranslatingVariantVasculitisbasecandidate markerdesigndisease phenotypehuman diseaseimprovedinhibitor/antagonistinsightinterestmouse modelmyelopoietinneutrophilnovelnovel therapeuticsperipheral bloodpreventreceptorresponsesmall moleculevascular inflammation

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