ADCC Genomic Medicine Approach to MCI and Dementia

描述(由申请人提供)：这是杜克大学医学中心约瑟夫和凯瑟琳·布莱恩阿尔茨海默病研究中心(布莱恩·ADRC)提交的一份新的ADCC文件。布莱恩ADRC成立于1985年，是一个多学科的研究中心，支持和开展阿尔茨海默病(AD)和相关疾病的基础科学和临床研究，重点是遗传易感性、早期诊断、尸检确认和教育推广。这些努力包括特别注重纳入少数群体，特别是非洲裔美国人，并强调我们基于临床的研究和基于人口的研究之间的方法协同作用。总的具体目标是：(1)为诊断、预防和治疗轻度认知障碍及其向痴呆的转变提供专门知识；(2)为确定、评估、纵向跟踪和参与研究提供结构和背景；(3)传播组织和提供研究所需的资源；(4)促进AD和相关疾病的临床和基础科学研究，促进AD生物学的进展，特别是基因组方法(遗传学、翻译研究、蛋白质组学、代谢组学等)。该中心的结构由四个核心以及一个私人支持的基因组核心组成，该核心由与杜克大学基因组科学与政策研究所(IGSP)和葛兰素史克公司的新合作推动。核心包括：临床；数据管理和统计；神经病理学；教育；以及每年两个试点项目(每年确定)。该中心整合、协调和促进了杜克大学和其他地方的跨学科合作。Bryan ADRC为新的基因组医学计划提供了重要的资源，例如，具有良好特征的患者和对照对象、家族信息、组织和生物标本。布莱恩ADRC及其与工业技术资源的巨大新链接所带来的公共卫生意义是一个高效、多产和充分合作的结构，导致发现AD和相关疾病的原因(S)，最终目标是开发科学、知情、合理和有效的方法来预防、护理和治疗记忆障碍，并全面改善医疗保健服务。

DESCRIPTION (provided by applicant): This is a new ADCC submission for the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center. The Bryan ADRC is a multidisciplinary research center established in 1985 which supports and conducts basic science and clinical research in Alzheimer's disease (AD) and related disorders with an emphasis on genetic predisposition, early diagnosis, autopsy confirmation, and educational outreach. Efforts include special focus on the inclusion of minority populations, specifically African-Americans and an emphasis on methodological synergy between our clinic-based and population-based studies. Overall specific aims are to: (1) provide expertise for the diagnosis, prevention, and treatment of mild cognitive disorders and their transition to dementia; (2) provide the structure and context for the ascertainment, evaluation, longitudinal follow-up and research participation of large MCI and AD patient samples and multiplex genetic families; (3) disseminate tissue and provide needed resources for research; (4) facilitate clinical and basic science research of AD and related disorders, leading to advances in the biology of AD with a particular emphasis on genomic approaches (genetics, translational studies, proteomics, metabolomics, etc). The Center's structure consists of four Cores along with a privately supported Genomics Core facilitated by new collaborations with the Institute of Genomic Sciences and Policy at Duke (IGSP) and Glaxo Smith Kline. The Cores include: Clinical; Data Management & Statistics; Neuropathology; and Education; along with two pilot projects per year (determined yearly). The Center integrates, coordinates, and fosters interdisciplinary collaborations at Duke and beyond. The Bryan ADRC provides important resources, e.g., well-characterized patients and control subjects, family information, tissue and biological specimens for the new genomic medicine initiatives. The public health significance brought to bear by the Bryan ADRC with its tremendous new links to technological resources in industry is an efficient, productive, and fully collaborative structure leading to the discovery of the cause(s) of AD and related illnesses with an ultimate goal of developing scientifically well-informed, rational, and effective approaches to the prevention, care, and treatment of memory disorders and overall improvement of health care delivery.