ADCC Genomic Medicine Approach to MCI and Dementia

描述（由申请人提供）：这是杜克大学医学中心约瑟夫和凯瑟琳·布莱恩阿尔茨海默病研究中心（布莱恩ADRC）的一份新的ADCC提交。Bryan ADRC是一个多学科研究中心，成立于1985年，支持并开展阿尔茨海默病（AD）及相关疾病的基础科学和临床研究，重点是遗传易感性、早期诊断、尸检确认和教育推广。努力包括特别关注纳入少数民族人群，特别是非洲裔美国人，并强调我们基于临床和基于人群的研究之间的方法协同作用。总体具体目标是：(1)提供诊断、预防和治疗轻度认知障碍及其向痴呆症过渡的专业知识；(2)为大型MCI和AD患者样本和多重遗传家族的确定、评估、纵向随访和研究参与提供结构和背景；(3)传播组织，提供研究所需的资源；(4)促进阿尔茨海默病及相关疾病的临床和基础科学研究，推动阿尔茨海默病生物学的进展，特别是基因组方法（遗传学、转化研究、蛋白质组学、代谢组学等）。该中心的结构包括四个核心，以及一个私人支持的基因组学核心，由杜克大学基因组科学与政策研究所（IGSP）和葛兰素史克（gsk Smith Kline）的新合作促进。核心包括：临床；数据管理与统计；神经病理学;和教育;同时每年有两个试点项目（每年确定）。该中心整合、协调和促进杜克大学内外的跨学科合作。Bryan ADRC为新的基因组医学计划提供了重要的资源，例如，具有良好特征的患者和对照受试者、家庭信息、组织和生物标本。Bryan ADRC与工业界技术资源的巨大新联系带来的公共卫生意义是一个高效，富有成效和充分合作的结构，导致发现AD和相关疾病的原因，最终目标是开发科学，充分了解，合理和有效的方法来预防，护理和治疗记忆障碍，并全面改善医疗保健服务。

DESCRIPTION (provided by applicant): This is a new ADCC submission for the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center. The Bryan ADRC is a multidisciplinary research center established in 1985 which supports and conducts basic science and clinical research in Alzheimer's disease (AD) and related disorders with an emphasis on genetic predisposition, early diagnosis, autopsy confirmation, and educational outreach. Efforts include special focus on the inclusion of minority populations, specifically African-Americans and an emphasis on methodological synergy between our clinic-based and population-based studies. Overall specific aims are to: (1) provide expertise for the diagnosis, prevention, and treatment of mild cognitive disorders and their transition to dementia; (2) provide the structure and context for the ascertainment, evaluation, longitudinal follow-up and research participation of large MCI and AD patient samples and multiplex genetic families; (3) disseminate tissue and provide needed resources for research; (4) facilitate clinical and basic science research of AD and related disorders, leading to advances in the biology of AD with a particular emphasis on genomic approaches (genetics, translational studies, proteomics, metabolomics, etc). The Center's structure consists of four Cores along with a privately supported Genomics Core facilitated by new collaborations with the Institute of Genomic Sciences and Policy at Duke (IGSP) and Glaxo Smith Kline. The Cores include: Clinical; Data Management & Statistics; Neuropathology; and Education; along with two pilot projects per year (determined yearly). The Center integrates, coordinates, and fosters interdisciplinary collaborations at Duke and beyond. The Bryan ADRC provides important resources, e.g., well-characterized patients and control subjects, family information, tissue and biological specimens for the new genomic medicine initiatives. The public health significance brought to bear by the Bryan ADRC with its tremendous new links to technological resources in industry is an efficient, productive, and fully collaborative structure leading to the discovery of the cause(s) of AD and related illnesses with an ultimate goal of developing scientifically well-informed, rational, and effective approaches to the prevention, care, and treatment of memory disorders and overall improvement of health care delivery.