ADCC Genomic Medicine Approach to MCI and Dementia

描述（由申请人提供）：这是杜克大学医学中心Joseph和Kathleen Bryan阿尔茨海默病研究中心（Bryan ADRC）的新ADCC提交资料。布赖恩ADRC是一个多学科研究中心成立于1985年，支持和进行基础科学和临床研究阿尔茨海默病（AD）和相关疾病的重点是遗传易感性，早期诊断，尸检确认和教育推广。努力包括特别注重纳入少数民族人口，特别是非洲裔美国人，并强调我们的临床和人口为基础的研究之间的方法协同作用。总体具体目标是：（1）为轻度认知障碍及其向痴呆的转变的诊断、预防和治疗提供专业知识;（2）为大型MCI和AD患者样本以及多重遗传家族的确定、评估、纵向随访和研究参与提供结构和背景;（3）传播组织并提供研究所需的资源;（4）促进AD和相关疾病的临床和基础科学研究，导致AD生物学的进步，特别强调基因组方法（遗传学、翻译研究、蛋白质组学、代谢组学等）。该中心的结构包括四个核心沿着与私人支持的基因组学核心促进与基因组科学和政策研究所在杜克（IGSP）和葛兰素史克公司的新合作。核心包括：临床;数据管理和统计;神经病理学;和教育;沿着每年两个试点项目（每年确定）。该中心整合，协调和促进杜克及其他学科的跨学科合作。Bryan ADRC提供了重要的资源，例如，充分表征的患者和对照受试者、家族信息、组织和生物标本，用于新的基因组医学倡议。Bryan ADRC通过其与工业技术资源的巨大新联系所带来的公共卫生意义是一个高效，富有成效和充分合作的结构，导致发现AD和相关疾病的原因，最终目标是开发科学的明智，合理和有效的预防，护理，以及治疗记忆障碍和全面改善保健服务。

DESCRIPTION (provided by applicant): This is a new ADCC submission for the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center. The Bryan ADRC is a multidisciplinary research center established in 1985 which supports and conducts basic science and clinical research in Alzheimer's disease (AD) and related disorders with an emphasis on genetic predisposition, early diagnosis, autopsy confirmation, and educational outreach. Efforts include special focus on the inclusion of minority populations, specifically African-Americans and an emphasis on methodological synergy between our clinic-based and population-based studies. Overall specific aims are to: (1) provide expertise for the diagnosis, prevention, and treatment of mild cognitive disorders and their transition to dementia; (2) provide the structure and context for the ascertainment, evaluation, longitudinal follow-up and research participation of large MCI and AD patient samples and multiplex genetic families; (3) disseminate tissue and provide needed resources for research; (4) facilitate clinical and basic science research of AD and related disorders, leading to advances in the biology of AD with a particular emphasis on genomic approaches (genetics, translational studies, proteomics, metabolomics, etc). The Center's structure consists of four Cores along with a privately supported Genomics Core facilitated by new collaborations with the Institute of Genomic Sciences and Policy at Duke (IGSP) and Glaxo Smith Kline. The Cores include: Clinical; Data Management & Statistics; Neuropathology; and Education; along with two pilot projects per year (determined yearly). The Center integrates, coordinates, and fosters interdisciplinary collaborations at Duke and beyond. The Bryan ADRC provides important resources, e.g., well-characterized patients and control subjects, family information, tissue and biological specimens for the new genomic medicine initiatives. The public health significance brought to bear by the Bryan ADRC with its tremendous new links to technological resources in industry is an efficient, productive, and fully collaborative structure leading to the discovery of the cause(s) of AD and related illnesses with an ultimate goal of developing scientifically well-informed, rational, and effective approaches to the prevention, care, and treatment of memory disorders and overall improvement of health care delivery.