RESEARCH ADMINISTRATION

研究管理

• 批准号: 8166142
• 负责人: HENRY LEWIS
• 金额: $ 60.91万
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166142
• 关键词: Amyloid beta-Protein; Anti-Inflammatory Agents; Anti-inflammatory; Area; Binding; Biochemistry; Biotechnology; Brain; Breathing; Chemicals; Chronic; Clozapine; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Drug Delivery Systems; Drug Formulations; Educational workshop; Estradiol; Evaluation; Faculty; Fatigue; Florida; Funding; Gel; Gene Expression; Grant; Human; Human Herpesvirus 6; Immunosuppression; In Vitro; Institution; Interdisciplinary Study; Knowledge; Mainstreaming; Malignant Neoplasms; Malignant neoplasm of lung; Mentors; Minority; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Nose; Outcome; Pathway interactions; Pharmacy (field); Pilot Projects; Prevention; Prevention therapy; Principal Investigator; Rattus; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Personnel; Research Proposals; Resources; Scientist; Signal Transduction; Skin; Source; Steroids; Technology; Testosterone; Training; United States National Institutes of Health; Universities; absorption; antimicrobial drug; cell transformation; disorder prevention; drug candidate; drug discovery; esterase; in vitro Model; inhibitor/antagonist; innovation; member; nanomedicine; nanoparticle; neurotoxicity; novel; novel strategies; prenylation; programs; research and development; skin irritation; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Florida A&M University (FAMU) Research Center in Minority Institutions (RCMI) Program consist of four (4) self-perpetuating Cores: Biotechnology" Pathways to Disease Prevention and Therapy; Drug Discovery - provide strategies to develop novel drug candidates that can be used for the treatment of neurodegenerative diseases; Neurodegeneration - provides researchers with an understanding of the direct and indirect neurotoxicity; and Nanomedicine - establishing resources and expertise in the area of nanoparticles technology) and an administrative component which facilitate interdisciplinary research collaboration and knowledge transfer leading to faculty submission of independent-research proposals. These Cores will provide University faculty members with the ability to embark on collaborative research activities at several levels internal and external to the organization. The RCMI Program provide support for three innovative research pilot projects in an effort to increase the number of minority scientists as independent investigators and further develop and enhance the University research infrastructure. Faculty investigators are engaged in research activities involving: Development of Topical Neuroinflammatory Inhibitors; HHV-6 Inhibition: Implications in Chronic Fatigue; Inhalation, topical, transdermal, nasal, and brain drug delivery; Nanomedicine with translational outcomes; Nanoparticle Drug Delivery; Synthesis and Pharmacological Evaluations of Potential Anti-Cancer and Anti Microbial Agents; Prevention of B(a)P Induced Cell Transformation by Organosulfur Compounds; Evaluation of Epiderm FT-200) culture as an in vitro model for skin irritation; Evaluations of formulations of Estradiol Gels; In Vitro Percutaneous Absorption of Testosterone through Human Skin; Novel Approaches in the Treatment of Lung Cancer; Pb/Mn: Cell Signaling and Gene Expression in Primary Neurons; Significance of Esterases in Prenylation Biochemistry; Studies on Skin Irritation and Immune Suppression of Selected Chemicals of JP-8 in rats; Synthesis and Evaluation of Agents with Clozapine-Like Dopaminergic Binding; Synthesis and Evaluation of New Local Anti-Inflammatory Steroids; and Uptake Mechanisms and Degradation of Amyloid Beta Protein in Neurons. Dr. Henry Lewis III serves as principal investigator and Dr. Karam F.A. Soliman serves as Program Director. Specific Aims (There are no changes in the specific aims) 1. Continue to provide administrative oversight to enhance the grants management and research development of the RCMI Programs 2. Recruit and hire a faculty member in the area of pharmaceutics 3. Provide mentoring program 4. Provide scientific seminars 5. Provide faculty development research funding 6. Provide workshops and training 7. Enhance the acquisition of mainstream funding: 8. Provide an RCMI evaluation plan for continues improvement:

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 佛罗里达农工大学(FAMU)少数民族院校研究中心(RCMI)计划由四(4)个自我延续的核心组成：生物技术“疾病预防和治疗之路”；药物发现-提供开发可用于治疗神经退行性疾病的新药候选的策略；神经退行性疾病-让研究人员了解直接和间接的神经毒性；纳米医学-建立纳米技术领域的资源和专业知识)和管理部分，促进跨学科研究合作和知识转移，导致教师提交独立研究建议书。这些核心将使大学教职员工能够在组织内部和外部的几个层面上开展合作研究活动。 RCMI方案为三个创新研究试点项目提供支持，以努力增加少数族裔科学家作为独立调查人员的数量，并进一步发展和加强大学的研究基础设施。学院研究人员从事的研究活动包括：开发局部神经炎症抑制剂；抑制HHV-6：对慢性疲劳的影响；吸入、局部、经皮、鼻腔和脑内给药；纳米药物与翻译结果；纳米粒给药；潜在抗癌和抗微生物药物的合成和药理学评价；有机硫化合物预防苯并(A)磷诱导的细胞转化；作为皮肤刺激体外模型的Epiderm(FT-200)培养的评价；雌二醇凝胶的配方评价；体外经人皮肤对睾酮的吸收；肺癌治疗的新方法；铅：细胞信号和原代神经元的基因表达；酯酶在预基化生物化学中的意义；JP-8部分化学物质对大鼠皮肤刺激和免疫抑制的研究；具有氯氮平样多巴胺能结合剂的合成和评价；新的局部抗炎类固醇的合成和评价；以及淀粉样β蛋白在神经元中的摄取机制和降解。亨利·刘易斯三世博士担任首席研究员，卡拉姆·F·A·索利曼博士担任项目主任。 具体目标(具体目标不变) 1.继续提供行政监督，加强RCMI方案的赠款管理和研究开发 2.招聘和聘用药剂学领域的教职员工 3.提供辅导计划 4.举办科学研讨会 5.提供教师发展研究经费 6.提供工作坊和培训 7.加强主流资金的获取： 8.为持续改进提供RCMI评估计划：