RESEARCH ADMINISTRATION

研究管理

• 批准号: 8166142
• 负责人: HENRY LEWIS
• 金额: $ 60.91万
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166142
• 关键词: Amyloid beta-Protein; Anti-Inflammatory Agents; Anti-inflammatory; Area; Binding; Biochemistry; Biotechnology; Brain; Breathing; Chemicals; Chronic; Clozapine; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Drug Delivery Systems; Drug Formulations; Educational workshop; Estradiol; Evaluation; Faculty; Fatigue; Florida; Funding; Gel; Gene Expression; Grant; Human; Human Herpesvirus 6; Immunosuppression; In Vitro; Institution; Interdisciplinary Study; Knowledge; Mainstreaming; Malignant Neoplasms; Malignant neoplasm of lung; Mentors; Minority; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Nose; Outcome; Pathway interactions; Pharmacy (field); Pilot Projects; Prevention; Prevention therapy; Principal Investigator; Rattus; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Personnel; Research Proposals; Resources; Scientist; Signal Transduction; Skin; Source; Steroids; Technology; Testosterone; Training; United States National Institutes of Health; Universities; absorption; antimicrobial drug; cell transformation; disorder prevention; drug candidate; drug discovery; esterase; in vitro Model; inhibitor/antagonist; innovation; member; nanomedicine; nanoparticle; neurotoxicity; novel; novel strategies; prenylation; programs; research and development; skin irritation; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Florida A&M University (FAMU) Research Center in Minority Institutions (RCMI) Program consist of four (4) self-perpetuating Cores: Biotechnology" Pathways to Disease Prevention and Therapy; Drug Discovery - provide strategies to develop novel drug candidates that can be used for the treatment of neurodegenerative diseases; Neurodegeneration - provides researchers with an understanding of the direct and indirect neurotoxicity; and Nanomedicine - establishing resources and expertise in the area of nanoparticles technology) and an administrative component which facilitate interdisciplinary research collaboration and knowledge transfer leading to faculty submission of independent-research proposals. These Cores will provide University faculty members with the ability to embark on collaborative research activities at several levels internal and external to the organization. The RCMI Program provide support for three innovative research pilot projects in an effort to increase the number of minority scientists as independent investigators and further develop and enhance the University research infrastructure. Faculty investigators are engaged in research activities involving: Development of Topical Neuroinflammatory Inhibitors; HHV-6 Inhibition: Implications in Chronic Fatigue; Inhalation, topical, transdermal, nasal, and brain drug delivery; Nanomedicine with translational outcomes; Nanoparticle Drug Delivery; Synthesis and Pharmacological Evaluations of Potential Anti-Cancer and Anti Microbial Agents; Prevention of B(a)P Induced Cell Transformation by Organosulfur Compounds; Evaluation of Epiderm FT-200) culture as an in vitro model for skin irritation; Evaluations of formulations of Estradiol Gels; In Vitro Percutaneous Absorption of Testosterone through Human Skin; Novel Approaches in the Treatment of Lung Cancer; Pb/Mn: Cell Signaling and Gene Expression in Primary Neurons; Significance of Esterases in Prenylation Biochemistry; Studies on Skin Irritation and Immune Suppression of Selected Chemicals of JP-8 in rats; Synthesis and Evaluation of Agents with Clozapine-Like Dopaminergic Binding; Synthesis and Evaluation of New Local Anti-Inflammatory Steroids; and Uptake Mechanisms and Degradation of Amyloid Beta Protein in Neurons. Dr. Henry Lewis III serves as principal investigator and Dr. Karam F.A. Soliman serves as Program Director. Specific Aims (There are no changes in the specific aims) 1. Continue to provide administrative oversight to enhance the grants management and research development of the RCMI Programs 2. Recruit and hire a faculty member in the area of pharmaceutics 3. Provide mentoring program 4. Provide scientific seminars 5. Provide faculty development research funding 6. Provide workshops and training 7. Enhance the acquisition of mainstream funding: 8. Provide an RCMI evaluation plan for continues improvement:

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Florida A&M University (FAMU) Research Center in Minority Institutions (RCMI) Program consist of four (4) self-perpetuating Cores: Biotechnology" Pathways to Disease Prevention and Therapy; Drug Discovery - provide strategies to develop novel drug candidates that can be used for the treatment of neurodegenerative diseases; Neurodegeneration - provides researchers with an understanding of the direct and indirect neurotoxicity; and纳米医学 - 在纳米粒子技术领域建立资源和专业知识），并有助于跨学科研究合作和知识转移，从而导致教师提交这些核心的教职员工，这些核心将为大学教职员工提供一些能力。 RCMI计划为三个创新的研究试点项目提供了支持，以增加少数族裔科学家的数量，并进一步发展和增强大学研究基础设施。 教师研究人员从事涉及的研究活动：局部神经炎症抑制剂的发展； HHV-6抑制作用：慢性疲劳的影响；吸入，局部，透皮，鼻和脑药物递送；具有转化结果的纳米医学；纳米粒子药物递送；潜在抗癌和抗微生物剂的合成和药理评估；预防B（a）P诱导有机硫化合物诱导细胞转化；评估表皮FT-200）培养作为皮肤刺激的体外模型；评估雌二醇凝胶的配方；体外经皮通过人皮肤吸收睾丸激素；肺癌治疗的新方法； PB/MN：原发性神经元中的细胞信号传导和基因表达；酯酶在原始生物化学中的重要性；对大鼠JP-8的选定化学物质的皮肤刺激和免疫抑制的研究；具有氯氮平样多巴胺能结合的药物的合成和评估；新局部抗炎类固醇的合成和评估；神经元中淀粉样蛋白β蛋白的摄取机理和降解。亨利·刘易斯三世（Henry Lewis III）博士担任首席研究员，Karam F.A. Soliman博士担任计划主任。 具体目标（具体目的没有任何变化） 1。继续提供行政监督，以增强RCMI计划的赠款管理和研究开发 2。招募和雇用药品领域的教职员工 3。提供指导计划 4。提供科学研讨会 5。提供教师发展研究资金 6.提供讲习班和培训 7。增强主流资金的收购： 8。提供RCMI评估计划以继续改进：