RENEWABLE CAPTORS FOR ADDICTION-RELEVANT PROTEINS

成瘾相关蛋白质的可再生捕获剂

• 批准号: 7952736
• 负责人: Catherine M Woods
• 金额: $ 20万
• 依托单位: AVANTGEN, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-10 至 2010-03-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952736
• 关键词: RENEWABLE; CAPTORS; ADDICTION; RELEVANT; PROTEINS

The objective of this project is to develop renewable antibodies against addiction-relevent proteins. Monoclonal antibodies (mAbs) have been the major affinity reagents as protein captures to date. However, development of mAbs with conventional hybridoma technology is time-consuming and costly. In vitro generated renewable antibodies are an excellent alternative to mAb, since these renewable antibodies are also of high specificity and affinity, and can be cost-effectively producted.

该项目的目标是开发针对成瘾相关蛋白的可再生抗体。 迄今为止，单克隆抗体 (mAb) 已成为蛋白质捕获的主要亲和试剂。 然而，利用传统杂交瘤技术开发单克隆抗体既耗时又昂贵。 体外生成的可再生抗体是 mAb 的绝佳替代品，因为这些可再生抗体还具有高特异性和亲和力，并且可以经济有效地生产。