Laboratory Testing Services

实验室测试服务

• 批准号: 7789088
• 负责人: CYNTHIA BESCH-WILLIFORD
• 金额: $ 55万
• 依托单位: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-10 至 2013-01-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789088
• 关键词: Laboratory; Testing; Services

A part of the search for active agents against Cancer and AIDS involves in vivo testing. The National Cancer Institute (NCI) maintains the Animal Production Program to supply the necessary laboratory animals needed for this in vivo testing. Much of the testing is performed in inbred laboratory animals such as the ones produced by the Animal Production Program contract colonies. Thus, a genetic monitoring contract is used to determine the genetic purity of the Animal Production Program inbred rodent colonies. The validation and verification of the genetic status of the NCI Animal Production Program is the primary objective of this effort. This effort is accomplished by utilizing DNA-based methods to determine genetic purity along with backup methods of biochemical markers and skin grafts.

寻找抗癌症和艾滋病的活性剂的一部分涉及体内测试。美国国家癌症研究所（NCI）维持动物生产计划，以提供该体内试验所需的必要实验室动物。大部分测试是在近交系实验室动物中进行的，例如动物生产计划合同殖民地生产的动物。因此，使用遗传监测合同来确定动物生产计划近交啮齿动物群体的遗传纯度。NCI动物生产计划的遗传状态的确认和验证是这项工作的主要目标。这项工作是通过利用DNA为基础的方法来确定遗传纯度沿着与生化标记和皮肤移植的备份方法。