Support of NCI CCR Clinical Research and Bioinformatics

该项目涉及国家癌症研究所，NCI，癌症研究中心，CCR的许多方面的支持。我们主持的项目包括一个名为Labmatrix的组织研究和库存系统。2009年，Labmatrix开始对12项新的人体研究进行组织管理。Labmatrix还增加了几个新的定制接口，专门用于简化数据输入。我们编写了一个名为Protocols的应用程序并将其投入生产。该系统提供便携式文档格式，PDF，所有活跃的CCR临床研究协议的版本在一个可搜索的web界面。协议在整个CCR临床项目中使用，也包括在临床中心的重要网站链接列表中。已经为几个下一代测序项目提供了支持。成功管理新一代测序机所需的数据量和计算能力需要网络团队、空间和设施之间的协调，而SAIC Frederick则提供了实际运行测序仪的承包商。CCR的人类癌变实验室在开发基于R语言的生物信息学处理系统方面得到了支持，并命名为LinkMotor。处理服务器和大规模存储由CBIIT的NCI生物信息学和信息技术中心提供，以支持LinkMotor。CCR临床研究系统需要重要的信息技术和生物信息学支持，以保持其有效运作。合同协调和监督由CCR信息技术办公室提供。在CCR的临床研究项目中，为一个名为iRIS的应用程序提供支持和系统维护。iRIS处理超过200个人类受试者临床研究方案的提交、审查和维护。该接口经过修改，以满足NCI的目标，即在提交科学审查后90天批准研究方案。

This project is involved in many aspects of support for the National Cancer Institute, NCI, Center for Cancer Research, CCR. Projects which we host include a tissue research and inventory system called Labmatrix. In 2009 Labmatrix began tissue management for 12 new human research studies. Labmatrix was also augmented with several new custom interfaces specifically to streamline the entering of data. We wrote and brought into production an application called Protocols. This system provides Portable Document Format, PDF, versions of all active CCR clinical research protocols in a searchable web interface. Protocols is used throughout the CCR clinical program and is also included on the Clinical Center's list of important web links. Support has been provide to several next generation sequencing projects. The amount of data generated and the computing power needed to successfully manage our new next generation sequencing machines required coordination between network teams, space and facilites, and SAIC Frederick which provided the contractors actually run the sequencers. The Laboratory of Human Carcinogenesis in the CCR received support in the developement of a bioinformatics processsing system built upon the R language, and named LinkMotor. Processing servers and large scale storage was negotiated to be provided from NCI Center for Bioinformatics and Information Technology, CBIIT, in support of LinkMotor. The CCR Clinical Research System requires significant information technology and bioinformatics support to keep it operating in an efficient manner. Contract coordination and oversight is provided by the CCR Office of Information Technology. Support and systems maintenance was provided to an application called iRIS, in the CCR's clinical research program. iRIS handles the submission, review and maintenance of over 200 human subjects clinical research protocols. The interface was modified to meet the NCI's goals of approving research protocols 90 days after their submission for scientific review.