Support of NCI CCR Clinical Research and Bioinformatics

该项目涉及对国家癌症研究所、NCI、CCR癌症研究中心的许多方面的支持。我们主持的项目包括一个名为LabMatrix的组织研究和库存系统。2009年，LabMatrix开始为12项新的人体研究进行组织管理。LabMatrix还增加了几个新的定制界面，专门用于简化数据的输入。我们编写了一个名为协议的应用程序并将其投入生产。该系统在可搜索的Web界面中提供可移植文档格式、PDF、所有现行CCR临床研究方案的版本。协议在整个CCR临床计划中使用，也包括在临床中心的重要网络链接列表中。已经向几个下一代测序项目提供了支持。成功管理我们的新一代测序仪所需的数据量和计算能力需要网络团队、空间和设施之间的协调，以及为承包商提供实际操作测序仪的SAIC Frederick。CCR中的人类癌症发生实验室在开发基于R语言的生物信息学处理系统方面得到了支持，并命名为LinkMotor。与NCI生物信息学和信息技术中心协商提供处理服务器和大规模存储，以支持LinkMotor。CCR临床研究系统需要重要的信息技术和生物信息学支持，以保持其高效运行。合同协调和监督由CCR信息技术办公室提供。在CCR的临床研究计划中，向一个名为Iris的应用程序提供了支持和系统维护。IRIS负责200多个人类受试者临床研究方案的提交、审查和维护。界面进行了修改，以满足NCI的目标，即在提交科学审查后90天批准研究方案。

This project is involved in many aspects of support for the National Cancer Institute, NCI, Center for Cancer Research, CCR. Projects which we host include a tissue research and inventory system called Labmatrix. In 2009 Labmatrix began tissue management for 12 new human research studies. Labmatrix was also augmented with several new custom interfaces specifically to streamline the entering of data. We wrote and brought into production an application called Protocols. This system provides Portable Document Format, PDF, versions of all active CCR clinical research protocols in a searchable web interface. Protocols is used throughout the CCR clinical program and is also included on the Clinical Center's list of important web links. Support has been provide to several next generation sequencing projects. The amount of data generated and the computing power needed to successfully manage our new next generation sequencing machines required coordination between network teams, space and facilites, and SAIC Frederick which provided the contractors actually run the sequencers. The Laboratory of Human Carcinogenesis in the CCR received support in the developement of a bioinformatics processsing system built upon the R language, and named LinkMotor. Processing servers and large scale storage was negotiated to be provided from NCI Center for Bioinformatics and Information Technology, CBIIT, in support of LinkMotor. The CCR Clinical Research System requires significant information technology and bioinformatics support to keep it operating in an efficient manner. Contract coordination and oversight is provided by the CCR Office of Information Technology. Support and systems maintenance was provided to an application called iRIS, in the CCR's clinical research program. iRIS handles the submission, review and maintenance of over 200 human subjects clinical research protocols. The interface was modified to meet the NCI's goals of approving research protocols 90 days after their submission for scientific review.