Support of NCI CCR Clinical Research and Bioinformatics

NCI CCR 临床研究和生物信息学支持

• 批准号: 7970393
• 负责人: Jeffrey Shilling
• 金额: $ 82.97万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7970393
• 关键词: Bioinformatics; CCR; Clinical; Clinical Research; Clinical Research Protocols; Contractor; Contracts; Custom; Data; Data Storage and Retrieval; Equipment and supply inventories; Goals; Human; Information Technology; Internet; Iris; Laboratories; Language; Link; Maintenance; Mediation; NCI Center for Cancer Research; Names; National Cancer Institute; Process; Production; Protocols documentation; Research; Research Personnel; Running; Support System; System; Systems Analysis; Technology; Tissues; United States National Institutes of Health; Writing; carcinogenesis; human subject; meetings; next generation; prevent; programs; research study; web interface

This project is involved in many aspects of support for the National Cancer Institute, NCI, Center for Cancer Research, CCR. Projects which we host include a tissue research and inventory system called Labmatrix. In 2009 Labmatrix began tissue management for 12 new human research studies. Labmatrix was also augmented with several new custom interfaces specifically to streamline the entering of data. We wrote and brought into production an application called Protocols. This system provides Portable Document Format, PDF, versions of all active CCR clinical research protocols in a searchable web interface. Protocols is used throughout the CCR clinical program and is also included on the Clinical Center's list of important web links. Support has been provide to several next generation sequencing projects. The amount of data generated and the computing power needed to successfully manage our new next generation sequencing machines required coordination between network teams, space and facilites, and SAIC Frederick which provided the contractors actually run the sequencers. The Laboratory of Human Carcinogenesis in the CCR received support in the developement of a bioinformatics processsing system built upon the R language, and named LinkMotor. Processing servers and large scale storage was negotiated to be provided from NCI Center for Bioinformatics and Information Technology, CBIIT, in support of LinkMotor. The CCR Clinical Research System requires significant information technology and bioinformatics support to keep it operating in an efficient manner. Contract coordination and oversight is provided by the CCR Office of Information Technology. Support and systems maintenance was provided to an application called iRIS, in the CCR's clinical research program. iRIS handles the submission, review and maintenance of over 200 human subjects clinical research protocols. The interface was modified to meet the NCI's goals of approving research protocols 90 days after their submission for scientific review.

该项目参与了对国家癌症研究所的多方面支持， NCI，癌症研究中心。我们主持的项目包括组织研究和 一个叫做LabMatrix的库存系统。2009年，Labmatrix开始为12名新人类进行组织管理。 研究。Labmatrix还增加了几个新的自定义界面， 简化数据输入。我们编写了一个名为 协议.该系统提供所有活动CCR的可移植文档格式（PDF）版本 临床研究协议在一个可搜索的网络界面。协议在整个 CCR临床计划，也被列入临床中心的重要网站列表 链接.已为多个下一代测序项目提供支持。的量 生成的数据和成功管理我们新的下一代产品所需的计算能力 测序机需要网络团队、空间和设施与SAIC之间的协调 弗雷德里克提供的承包商实际上运行测序仪。人类实验室 CCR中的致癌作用在生物信息学处理的发展中得到了支持， 系统基于R语言构建，命名为LinkMotor。处理服务器和大规模 经协商，存储由NCI生物信息学和信息中心提供 技术，CBIIT，支持LinkMotor。CCR临床研究系统要求 重要的信息技术和生物信息学支持，以保持其运作， 有效方式合同协调和监督由CCR办公室提供， 信息技术.为一个名为“联合国开发计划署”的应用程序提供了支持和系统维护， iRIS，在CCR的临床研究计划中。iRIS处理提交、审查和 维护200多名人类受试者的临床研究方案。界面被修改了 以满足NCI的目标，即在提交研究方案后90天内批准研究方案， 科学评论