Chromatin Remodeling and Lymphocyte Regulation

染色质重塑和淋巴细胞调节

• 批准号: 7963986
• 负责人: MICHAEL J PAZIN
• 金额: $ 48.02万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7963986
• 关键词: Asthma; Binding Sites; Cell Differentiation process; Cell Line; Chromatin Structure; Complex; Cytokine Gene; Future; Gene Expression; Gene Expression Regulation; Hypersensitivity; Link; Lymphocyte; Mus; Parasites; Play; Recruitment Activity; Regulation; Rest; Role; SMARCA4 gene; Site; T-Lymphocyte; Th1 Cells; Th2 Cells; chromatin remodeling; cytokine; extracellular; fighting; transcription factor

Previously, we found that chromatin remodeling was required for Th2 cytokine gene expression. We found that transcription factors recruited BRG1 to specific sites in Th2 cells. BRG1 was required before and after Th2 differentiation. Progress: We identified the BAF version of the SWI-SNF complex as a regulator of Th2 gene expression. We found BRG1 binding sites in stimulated Th2 cells were different than in resting Th2 cells or stimulated Th1 cells. We found preliminary evidence for the involvement of SWI/SNF in other Th fates. Future: Remodeling and other cytokine loci. Remodeling and other T cell fates.

以前，我们发现Th2细胞因子基因表达需要染色质重塑。 我们发现转录因子募集了BRG1到Th2细胞中的特定位点。 Th2分化之前和之后需要BRG1。 进步： 我们将SWI-SNF复合物的BAF版本确定为Th2基因表达的调节剂。 我们发现刺激的Th2细胞中的BRG1结合位点与静止的Th2细胞或刺激的Th1细胞不同。 我们发现了SWI/SNF参与其他命运的初步证据。 未来： 重塑和其他细胞因子基因座。 重塑和其他T细胞命运。