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Metabolism

Metabolism
代谢
批准号：
7750209
负责人：
William C Stanley
金额：
$28.67万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-08-14 至 2014-07-31
来源：
https://reporter.nih.gov/project-details/7750209
关键词：
5&apos-AMP-activated protein kinaseAcetyl-CoA CarboxylaseAcyl Coenzyme AAtrial Natriuretic FactorBiochemicalBiological AssayBloodBlood specimenBody CompositionCanis familiarisCardiacCarnitine O-PalmitoyltransferaseChargeCitrate (si)-SynthaseCoronaryEnergy MetabolismEquipmentGenesGlucagonGlucoseGlycogenGrantHeart failureHormonesIL6 geneIndividualInsulinL-GlucoseLabelLaboratory PersonnelLeptinLinkMeasurementMeasuresMessenger RNAMetabolicMetabolismMethodsMitochondriaMusMyocardialMyocardial tissueMyosin Heavy ChainsNonesterified Fatty AcidsPlasmaPrincipal InvestigatorProtein BiosynthesisProtein IsoformsProteinsProto-Oncogene Proteins c-aktResearch PersonnelReverse Transcriptase Polymerase Chain ReactionSamplingSchemeSerumServicesTimeTissue SampleTissuesTracerTriglyceridesTumor Necrosis Factor-alphaWaterWestern BlottingWorkadiponectincytokineenzyme activityheart metabolismhuman TNF proteinin vivomRNA Expressionmetabolic abnormality assessmentoxidationpressureprogramsprotein expressionpyruvate dehydrogenaseresearch studyuptake

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中文摘要
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英文摘要
The objective of the Metabolism core is to provide the to PPG investigators the scientific and technical support for the execution of biochemical analyses of blood and myocardial tissue samples from all four Projects in the PPG. The Core will perform metabolic and isotopic tracer analysis of blood and tissue from the dogs studied in Projects 1, 2 and 3, and will oversee the experiments with doubly labeled water in mice and dogs in Project 1. The Core will also assess the expression and activity of selected proteins, measure the content of key regulatory metabolites (e.g ATP, lactate, etc), measure mRNA expression for selected genes, and plasma hormone levels. The measurement of Inflamatory cytokines for Project 1 will be performed by the Core. All of the expertise and equipment necessary for these measurements is in place.
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会议论文
Mitochondrial Proteome Dynamics in Heart Failure Assessed with Heavy Water
  • 批准号：
    8401772
  • 项目类别：
  • 资助金额：
    $21.74万
  • 财政年份：
    2012
  • 负责人：
    William C Stanley
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Docosahexaenoic Acid, Mitochondrial Dysfunction and Cardiac Reperfusion Injury
  • 批准号：
    8205687
  • 项目类别：
  • 资助金额：
    $23.03万
  • 财政年份：
    2011
  • 负责人：
    William C Stanley
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Docosahexaenoic Acid, Mitochondrial Dysfunction and Cardiac Reperfusion Injury
  • 批准号：
    8319356
  • 项目类别：
  • 资助金额：
    $19.19万
  • 财政年份：
    2011
  • 负责人：
    William C Stanley
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Administration
  • 批准号：
    7750207
  • 项目类别：
  • 资助金额：
    $28.67万
  • 财政年份：
    2009
  • 负责人：
    William C Stanley
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
海外基金