Task 09 (C21): Development of a Murine Model for Plague Vaccines

新兴疾病和生物防御的体外和动物模型合同提供了小动物和非人类灵长类动物模型的开发和标准化，包括疫苗的有效性测试，包括GLP研究以支持产品许可。在小动物中有效的疫苗可以在非人灵长类动物模型中进一步测试。该合同还提供了在GLP下在小动物以及非人灵长类动物中进行的疫苗安全性和免疫原性测试，包括体液和细胞免疫。

The In Vitro and Animal Models for Emerging Diseases and Biodefense contract provides the development and standardization of small animal and non-human primate models, and includes efficacy testing of vaccines, including GLP studies to support product licensure. Vaccines that are efficacious in small animals may be further tested in non-human primate models. This contract also provides testing of vaccines for safety and immunogenicity, to include humoral and cellular immunity, in small animals as well as non-human primates, under GLP where appropriate.