BONE DENSITY IN CHILDHOOD - CLINICAL CENTER

儿童期骨矿物质密度研究（BMDCS）的目的是获得标准参考骨矿物质密度测量值，同时考虑骨骼成熟、骨大小和体积、体型和青春期阶段。这些数据将作为一个非常有价值的标准儿科BMD数据库。它预计将成为必不可少的参考，将使儿科医生研究，诊断和治疗儿童的疾病影响骨积累。临床中心和数据协调中心的六份合同于2001年8月1日授予。这五个学术临床中心都遵守一个共同的纵向观察协议，包括基线和连续三年的年度评估，包括双X射线吸收测定法（DXA）和骨龄X射线，一项体格检查，以确定他们的青春期状态，测距仪身高，体重和体重指数（BMI）。此外，三个研究中心正在对一部分儿童进行CT或pQCT扫描。每年从每个孩子那里获得有关骨骼健康的信息，如饮食和锻炼。骨龄X射线和DXA扫描集中解释。招募于2002年7月在五个临床中心开始，截至2003年11月1日，招募了1554名6-16岁的儿童，包括所有种族和性别。

The purpose of the bone mineral density in childhood study (BMDCS) is to obtain standard reference bone mineral density measures taking into consideration skeletal maturation, bone size and volume, body size, and pubertal stage. These data will serve as an extremely valuable standard pediatric BMD database. It is anticipated to become the essential reference that will enable pediatricians to study, diagnose, and treat children with disorders affecting bone accrual. The six contracts for the Clinical Centers and the Data Coordinating Center were awarded on August 1, 2001. The five academic clinical centers all adhere to a common longitudinal observational protocol involving a baseline and three consecutive annual evaluations, including dual x-ray absorptiometry (DXA) and bone age x-ray, a physical exam to determine their pubertal status, stadiometer height, weight, and body mass index (BMI). Additionally, three sites are performing CT or pQCT scans on a subset of children. Information relating to bone health such as diet and exercise is obtained from each child annually. The bone age x-ray and DXA scans are interpreted centrally. Recruitment commenced in July 2002 at five Clinical Centers and resulted in the enrollment by November 1, 2003 of 1554 children from 6-16 years old of both genders and all racial groups.