AREA I BIOMOLECULAR STRUCTURE & FUNCTION: AIDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 第一个主要领域的目标是阐明生物的结构和功能。 分子，目的是了解和解释它们在发育中的功能 在细胞活动中。续签五年的一项重大新举措是招募一名新的 确定蛋白质结构的X射线衍射领域的教员 并提供启动资金来装备这个设施。我们租用X光片的要求 结晶学家的动机是需要补充和加强正在进行的 由核磁共振进行的结构工作。我们还获得了X射线结晶学 设备由诺华公司捐赠，并于#年通过学院的资金建立 CCNY的新路径生物信息学和生物技术中心。 生物化学和结构生物学的最新发展使第一区的成员能够 进一步将研究领域拓展到大分子和大分子 装配。为了提高生产力和竞争力，他们必须利用新的 技术，并转向更多地使用核磁共振技术与核磁共振 这些设施是纽约市结构生物学中心不可或缺的。与这一目标一致 我们增加了Sacha de Carlo博士，他的研究重点是3D电子显微镜和计算机辅助 图像处理技术用于研究所涉及的分子组装的结构、功能和动力学 在蛋白质折叠和转录等基本生物过程中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major Area I goals are to elucidate the structures and functions of biological molecules with the aim of understanding and explaining their functions in development and in cellular events. A major new initiative for the five-year renewal is to recruit a new faculty member in the area of X-ray diffraction for the determination of protein structure and to provide startup funds to equip this facility. Our request for the hire of an X-ray crystallographer is motivated by the need to complement and enhance the ongoing structural work carried out by NMR. We have also secured X-ray crystalography equipment which was donated by Novartis and set up through funds from the college in the new Pathways Bioinformatics and Biotechnology Center at CCNY. Recent developments in biochemistry and structural biology allow members of Area I to further expand their areas of study into large macromolecules and macromolecular assemblies. To be more productive and competitive, they must exploit the new technologies and turn to increased use of NMR techniques in conjunction with the NMR facilities that are integral to the New York City Structural Biology Center. In accord with this goal we have added Dr. Sacha De Carlo whose research focuses on 3D electron microscopy and computer-assisted image processing to study the structure, function and dynamics of molecular assemblies involved in fundamental biological processes such as protein folding and transcription.