AREA I BIOMOLECULAR STRUCTURE & FUNCTION: AIDS

I 区生物分子结构

• 批准号: 8166246
• 负责人: DAVID CALHOUN
• 金额: $ 63.11万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166246
• 关键词: Area; Biochemistry; Bioinformatics; Biological Process; Biotechnology; Complement; Computer Retrieval of Information on Scientific Projects Database; Computer-Assisted Image Processing; Development; Electron Microscopy; Equipment; Event; Faculty; Funding; Genetic Transcription; Goals; Grant; Institution; New York City; Pathway interactions; Recruitment Activity; Research; Research Personnel; Resources; Roentgen Rays; Secure; Source; Structure; Techniques; United States National Institutes of Health; Work; X ray diffraction analysis; X-Ray Diffraction; college; macromolecular assembly; macromolecule; member; molecular assembly/self assembly; new technology; protein folding; protein structure; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major Area I goals are to elucidate the structures and functions of biological molecules with the aim of understanding and explaining their functions in development and in cellular events. A major new initiative for the five-year renewal is to recruit a new faculty member in the area of X-ray diffraction for the determination of protein structure and to provide startup funds to equip this facility. Our request for the hire of an X-ray crystallographer is motivated by the need to complement and enhance the ongoing structural work carried out by NMR. We have also secured X-ray crystalography equipment which was donated by Novartis and set up through funds from the college in the new Pathways Bioinformatics and Biotechnology Center at CCNY. Recent developments in biochemistry and structural biology allow members of Area I to further expand their areas of study into large macromolecules and macromolecular assemblies. To be more productive and competitive, they must exploit the new technologies and turn to increased use of NMR techniques in conjunction with the NMR facilities that are integral to the New York City Structural Biology Center. In accord with this goal we have added Dr. Sacha De Carlo whose research focuses on 3D electron microscopy and computer-assisted image processing to study the structure, function and dynamics of molecular assemblies involved in fundamental biological processes such as protein folding and transcription.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 第一领域的主要目标是阐明生物蛋白质的结构和功能， 分子，目的是理解和解释它们在发育中的功能 和细胞事件中。 五年续约的一项重大新举措是招募一名新的 X射线衍射蛋白质结构测定领域的教员 并提供启动资金来装备这个设施。 我们请求租用一台X光透视机 晶体学家的动机是需要补充和加强正在进行的 通过NMR进行的结构工作。 我们还做了X射线晶体分析 这是由诺华捐赠的设备，并通过学院的资金建立， 新的途径生物信息学和生物技术中心在CCNY。 生物化学和结构生物学的最新发展使I区的成员能够 进一步扩大研究领域，进入大分子和高分子 组件. 为了提高生产力和竞争力，他们必须利用新的 技术，并转向增加使用核磁共振技术结合核磁共振 这些设施是纽约市结构生物学中心不可或缺的。 与这个目标雅阁 我们增加了Sacha De Carlo博士，他的研究重点是3D电子显微镜和计算机辅助 图像处理，以研究所涉及的分子组装体的结构、功能和动力学 在基本的生物过程中，如蛋白质折叠和转录。