Anthropometric Assessment of Abdominal Obesity and Health Risk in Children and Ad

儿童腹部肥胖和健康风险的人体测量评估和广告

• 批准号: 7943116
• 负责人: Peter Todd Katzmarzyk
• 金额: $ 49.73万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7943116
• 关键词: 18 year old; Abdomen; Address; Adipose tissue; Adolescent; Adult; African American; Age; Ambulatory Care Facilities; Anatomic Sites; Area; Biological; Biomedical Research; Body fat; Budgets; Caucasians; Caucasoid Race; Central obesity; Child; Childhood; Chronic Disease; Clinical; Clinical Research; Consensus; Country; Cross-Sectional Studies; Development; Dimensions; Early identification; Economics; Fatty acid glycerol esters; Funding; Goals; Health; Healthcare; Human body; Image; Imaging Techniques; Individual Differences; Intra-abdominal; Laboratories; Limb structure; Magnetic Resonance Imaging; Measurement; Measures; Metabolic Diseases; Methodology; Methods; Obesity; Occupations; Participant; Pediatric Research; Population; Positioning Attribute; Prevalence; Procedures; Protocols documentation; Public Health; Race; Recruitment Activity; Research; Research Design; Resources; Risk; Risk Factors; Sampling; Standardization; Stream; Techniques; Time; Umbilicus; Visceral; abdominal fat; boys; clinical decision-making; cost effective; disorder risk; experience; girls; indexing; obesity in children; public health relevance; racial difference; rib bone structure; sex; subcutaneous; surveillance strategy; waist circumference

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research, and Specific Challenge Topic 06- DK-106: Identifying a Standard Anthropometric Measure for Pediatric Central Adiposity. Abdominal fat, in particular intra-abdominal visceral adipose tissue is considered to be the most dyslipidemic and atherogenic fat depot in the human body. Intra-abdominal visceral adipose tissue and total body fat can be measured precisely and reliably in a laboratory setting using advanced imaging techniques; however, reliable clinical measurements of pediatric intra-abdominal visceral adipose tissue and total body fat are yet to be developed. Early identification is essential to addressing the expanding problem of pediatric obesity and metabolic disease. Thus, the specific aims of this study are to 1) identify reliable landmarks and methodology for the measurement of pediatric waist circumference that are associated with intra-abdominal visceral adipose tissue and total body fat across the pediatric age (5 to 18 years of age), total body adiposity, and biological maturity range among African American and Caucasian children and adolescents, 2) determine if waist circumference in combination with other anthropometric indices is a better predictor of intra-abdominal visceral adipose tissue and total body fat than waist circumference alone across the pediatric age, total body adiposity, and maturation range, and 3) develop and determine the clinical utility of pediatric race-sex-specific waist circumference thresholds for the identification of elevated chronic disease risk factors across the pediatric age, total body adiposity, and maturation range. We will accomplish these aims by conducting a cross-sectional study of 100 African American boys, 100 Caucasian boys, 100 African American girls, and 100 Caucasian girls 5 to 18 years of age. Waist circumference will be measured at the four common anatomic sites used in pediatric research: 1) superior border of the iliac crest, 2) midpoint between the iliac crest and the lowest rib, 3) umbilicus, and 4) minimal waist. Additional body dimensions will be obtained in order to determine the clinical utility of combining waist circumference with other measurements in predicting intra-abdominal visceral adipose tissue and total body fat, which will be assessed using advanced imaging techniques. The identification of the most appropriate waist circumference landmarks and measurement techniques is important for the clinical identification of children at elevated obesity-related health risk and for the standardization of obesity surveillance strategies within and between countries. PUBLIC HEALTH RELEVANCE (provided by applicant): Childhood obesity is a major public health issue, and the identification of children who are at increased risk of health problems due to their obesity is a priority for modern health care. Abdominal fat is considered to be the most harmful in the body, and the development of reliable landmarks and procedures for the assessment of intra-abdominal visceral adipose tissue and total body fat in children will have a major impact on 1) the early identification of children at elevated health risk, 2) the proper prioritization of health care resources, and 3) the standardization of obesity surveillance procedures within and between countries.

描述（由申请人提供）：本申请涉及广泛的挑战领域（04）临床研究和特定挑战主题06- DK-106：确定儿童中心性肥胖的标准人体测量方法。腹部脂肪，特别是腹内内脏脂肪组织被认为是人体中最具血脂异常和致动脉粥样硬化性的脂肪储存库。腹腔内内脏脂肪组织和全身脂肪可以在实验室环境中使用先进的成像技术进行精确可靠的测量;然而，儿科腹腔内内脏脂肪组织和全身脂肪的可靠临床测量方法尚未开发。早期识别是至关重要的，以解决日益扩大的问题，儿童肥胖和代谢疾病。因此，本研究的具体目的是：1）确定可靠的标志和方法，用于测量与整个儿科年龄段的腹内内脏脂肪组织和全身脂肪相关的儿科腰围（5至18岁），全身肥胖和生物成熟度范围在非洲裔美国人和高加索儿童和青少年中，2）确定在儿科年龄、全身肥胖和成熟范围内，腰围与其他人体测量指标组合是否比腰围单独更好地预测腹内内脏脂肪组织和全身脂肪，和3）开发和确定儿科种族-性别特异性腰围阈值的临床效用，以识别儿科年龄、全身肥胖和成熟范围内升高的慢性疾病风险因素。我们将通过对100名非洲裔美国男孩，100名白人男孩，100名非洲裔美国女孩和100名5至18岁的白人女孩进行横断面研究来实现这些目标。将在儿科研究中使用的四个常见解剖部位测量腰围：1）髂嵴的上级边缘，2）髂嵴和最低肋骨之间的中点，3）脐，和4）最小腰围。将获得额外的身体尺寸，以确定将腰围与其他测量值结合在预测腹腔内内脏脂肪组织和全身脂肪中的临床效用，将使用先进的成像技术进行评估。确定最合适的腰围标志和测量技术对于临床识别肥胖相关健康风险升高的儿童以及国家内部和国家之间肥胖监测策略的标准化非常重要。 公共卫生相关性（由申请人提供）：儿童肥胖是一个主要的公共卫生问题，识别因肥胖而面临健康问题风险增加的儿童是现代卫生保健的优先事项。腹部脂肪被认为是身体中最有害的，开发用于评估儿童腹内内脏脂肪组织和全身脂肪的可靠标志和程序将对以下方面产生重大影响：1）早期识别健康风险升高的儿童，2）适当优先考虑卫生保健资源，（3）国家内部和国家之间肥胖监测程序的标准化。