Study of Women's Health Across the Nation - Coordinating Center

描述（由申请人提供）：全国妇女健康研究（SWAN）是一项7中心多民族纵向研究，旨在描述更年期过渡期间发生的生理和社会心理变化。SWAN已经积累了十年的内分泌学数据，这些数据与中年健康和衰老有关。随着SWAN要求其第四次竞争性更新，该研究本身提出从更年期研究过渡到女性衰老研究。SWAN IV项目开始时参与者的平均年龄为59岁（54至65岁），SWAN IV将跟踪这些女性直至59至70岁。SWAN具有前所未有的能力，将其在中年和更年期过渡期间收集的广泛的生物学、医学、社会、行为和人口统计数据与老年早期积极和不良健康状态的发展联系起来。SWAN IV的主要目标是：1)绝经后（末次月经后2至12年）的内分泌学和症状特征；2)确定与早期老年范围相关的额外健康结果（如测量的身体表现），这些结果可能受到我们在中年研究的因素的影响；3)了解妇女的中年和更年期过渡经历与随后的积极和消极健康结果之间的关系。为了实现这一目标，研究人员建议每年进行一次电话联系，以密切跟踪更年期状况、更年期症状和选定的健康事件。此外，建议进行两次面对面的诊所访问，以完成早期疾病的详细物理测量。SWAN IV的主要专题领域包括：1)身体功能；2)骨/骨质疏松症;3)认知功能/症状/心理健康和4)心血管。SWAN的新领域包括身体表现和骨关节炎、重度抑郁史和颈动脉壁厚度。SWAN将继续监测症状、认知、心血管危险因素、内分泌、骨密度和骨折。SWAN IV将促进我们对与更年期过渡相关的可改变危险因素如何与亚临床疾病措施和硬结果相关联的理解。这可能导致改善初级预防妇女疾病的战略。

DESCRIPTION (provided by applicant): The Study of Women's Health Across the Nation (SWAN) is a 7-center multi-ethnic longitudinal study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. SWAN has amassed ten years of data about endocrinology of the transition and other factors relevant to midlife health and aging. As SWAN requests its fourth competing renewal, the study itself proposes to transition from a study of the menopause to a study of aging in women. The average age of participants at the beginning of the SWAN IV project will be 59 years (54 to 65) and SWAN IV will follow these women through the age range of 59 to 70. SWAN has the unprecedented capability to link the expansive biological, medical, social, behavioral, and demographic data it has collected during mid-life and the menopausal transition to the development of both positive and adverse health states in early oldage. The primary objectives of SWAN IV are to: 1) Characterize the endocrinology and symptomotology of the post-menopause (2 to 12 years after final menses); 2) Ascertain additional health outcomes (such as measured physical performance) that are relevant to the early old age range and that may be affected by the factors that we have studied in mid-life and 3) Understand the relations between the mid-life and menopausal transition experience of women and subsequent positive and negative health outcomes. To accomplish this, the investigators propose annual phone contact to closely track menopausal status, menopausal symptoms and selected health events. In addition, two in-person clinic visits are proposed to accomplish detailed physical measures of early disease. The major thematic areas of SWAN IV include 1) Physical Functioning; 2) Bone/Osteoporosis; 3) Cognitive Function/ Symptoms/ Mental Health and 4) Cardiovascular. New areas for SWAN include physical performance and osteoarthritis, history of major depression, and carotid wall thickness. SWAN will continue to monitor symptoms, cognition, cardiovascular risk factors, endocrinology, bone density and fractures. SWAN IV will advance our understanding of how modifiable risk factors related to the menopause transition are linked to sub-clinical disease measures and hard outcomes. This may lead to improved strategies for the primary prevention of disease in women. RELEVANCE: SWAN has compiled the most comprehensive characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples. Of particular public health importance is that the continuation of SWAN will permit the study to increase understanding of the effects of these menopause-related changes on subsequent health and risk factors for age-related diseases.