Cellular and molecular foundations of biomedical science

这项培训拨款提案的标题是“生物医学科学的细胞和分子基础”。这是一个 六年前开始的一个成功的项目的更新，旨在培养广泛的研究生 生物医学基础知识，为他们提供工具来理解 现代生物学与健康。这一点最初是通过两个学期的核心课程完成的 遗传学、基因组学与生物信息学、真核分子生物学、分子生物物理学、蛋白质 结构与功能和细胞生物学。学生在此基础上选修他们感兴趣的特定领域的课程。 这一跨部门计划的基础是生物科学部，但已扩大 包括哥伦比亚大学内科和外科学院的资深教职员工。学生承担 在最多三个实验室轮换，并可以在该项目的47名教职员工中的任何一人完成论文工作， 其中大约有一半在医学院校园里。这为以下项目提供了更多的机会 在优秀实验室对学生进行培训，并促进了教职员工和 哥伦比亚大学医学院和主要校区的学生。这些教员在广泛的领域工作。 包括结构生物学、分子生物学、遗传学、生物信息学和系统生物学、发育 生物学和神经生物学。实验系统也很广泛，包括细菌、酵母、果蝇、C. 优雅的，青蛙和老鼠。人体组织培养系统也被利用，大多数系统考虑 与人类健康和生理有关的问题。申请12个研究生实习生职位 每年资助六名学生，每人两年，通常是在他们的三年级和四年级。这将为19%的 我们目前的培训资助金合格学生人数为63人。我们项目中最优秀的学生将被选为 由这笔赠款提供资金。这将取决于他们在核心课程和其他课程中的表现， 来自他们的轮换和论文发起人的建议，以及由 格兰特的指导委员会。哥伦比亚大学的教职员工和研究机构的资质是 优秀，为学员提供了一流的训练环境。 相关性(请参阅说明)： 培养下一代生物医学科学家对于在 美国和在理解、控制和治疗人类疾病方面的进展。该计划中的实验室 解决生物医学科学中的具体基本问题，其中许多问题直接应用于人类疾病。

This training grant proposal is entitled "The cellular and molecular foundations of biomedical sciences". It is a renewal of a succesful program started six years ago and seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through a two semester Core course covering Genetics, Genomics and Bioinformatics, Eukaryotic molecular biology, Molecular biophysics, Protein structure and function, and Cell biology. Students follow this with electives in specific fields of their interest. This interdepartmental program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons. Students undertake rotations in up to three laboratories and can do their thesis work in any of the 47 faculty in the program, roughly half of which are on the Medical School campus. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty work in a broad range of fields including structual biology, molecular biology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relavant to human health and physiology. Twelve graduate student traineeships are requested per year to support six students for two years each, usually in their third and fourth years. This will fund 19%of our current training grant eligible student pool of 63. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provides a superb training environment for the students. RELEVANCE (Seeinstructions): The training of the next generation of biomedical scientists is essential to continued excellence of research in the U.S. and advances in understanding, controlling and curing human disease. Laboratories in the program address specific basic problems in biomedical sciences, many with direct applications to human disease.