Enhancement of RNA Related Research at Case Western Reserve University

描述(由申请人提供)：这项建议的目标是招聘两名终身教职跟踪助理教授RNA生物学家，一名专门从事生物信息学，一名专门研究基因组方法来研究非编码RNA，以加入和补充凯斯西储大学医学院RNA分子生物学中心的教职。我们相信，我们目前的教员在分子生物学和生物化学领域非常强大。同样明显的是，我们在这两个重要和令人兴奋的领域缺乏专门知识。关于第一个领域，虽然我们可以使用两台Solexa基因组分析仪，但我们必须寻求外部合作者来解释数据。我们迫切需要一位才华横溢的信息学家，既能维护自己的利益，又能担任内部专家。我们坚信，如果我们能够招募到合适的个人，我们的研究能力将会有一个巨大的飞跃。关于第二个领域，非常清楚的是，RNA研究的下一个前沿将是分析非编码RNA的功能--既有小的(例如mlRNAs、piRNAs)，也有大的(例如Xist)。我们认为大的非编码RNA特别有趣，因为小的RNA领域现在被大量填充。我们认为，如果我们能够招募到合适的研究人员，他/她将成为大型非编码RNA领域的领导者，并从该中心在分子和生化方法方面的专业知识中受益匪浅。此外，假设新兵对这个问题采取了全基因组的方法，他/她无疑会与信息学新兵协同工作。医学院院长一直高度支持凯斯西储大学的RNA研究，并承诺在本奖项授予后至少两年内支持任何招聘的教师。此外，她和综合癌症中心主任已承诺提供超过500,000美元用于建立RNA核心设施。我们预计，拟议的两名新调查员将立即增强我们进行多学科研究项目的能力。

DESCRIPTION (provided by applicant): The objective of this proposal is to recruit two tenure track Assistant Professor RNA biologists, one who specializes in bioinformatics and one who specializes in genomic approaches to the study of non-coding RNAs, to join and complement the faculty of the Center for RNA Molecular Biology at Case Western Reserve University School of Medicine. We believe that our current faculty are very strong in the areas of molecular biology and biochemistry. It is equally clear that we lack expertise in these two important and exciting areas. Regarding the first area, while we have access to two Solexa genome analyzers, we must seek outside collaborators to interpret the data. We desperately need a talented informatician who can maintain his/her own interests and also serve as an in house expert. We strongly believe that if we can recruit the appropriate individual, we will make a quantum leap forward in our research capability. Regarding the second area, it is abundantly clear that the next frontier in RNA research will be the analysis of the functions of non-coding RNAs- both small (e.g. mlRNAs, piRNAs) and large (e.g. Xist). We view large non-coding RNAs to be particularly interesting as the small RNA field is now heavily populated. We feel that if we can recruit the appropriate investigator, he/she will become a leader in the field of large non-coding RNAs and benefit greatly from the Center's expertise in molecular and biochemical approaches. Moreover, assuming the recruit takes a genome wide approach to this question he/she will undoubtedly synergize with the informatics recruit. The Dean of the Medical School has been highly supportive of RNA research at Case Western Reserve and has committed resources to support any recruited faculty for at least two years beyond the duration of this award if granted. In addition, she and the Director of Comprehensive Cancer Center have committed in excess of $500,000 for establishment of an RNA Core facility. We anticipate that the proposed two new investigators will immediately enhance our ability to conduct multidisciplinary research projects.