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中文摘要
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项目描述(由申请人提供):本项目的长期目标是在UCSF建立一个世界级的化学生物学团队。为了实现这一目标,我们的目标是招募一名新的教师来加强和扩大UCSF药物化学系的化学生物学小组。化学与生物交叉的科学一直是我们系的核心力量。UCSF的化学生物学小组开发化学工具和技术,以解决涉及医疗保健的关键生物学问题。由于该领域将对未来的生物医学科学和制药应用产生重大影响,加州大学旧金山分校已作出长期承诺,以发展和培养化学生物学组。招聘过程将按照大学规定的具体程序和政策进行,这些程序和政策强调公平、公开地寻找最合格的人才。由于最近的经济形势,可用于雇用新教师的启动资金严重减少。来自国家和私人捐助者的资金都在枯竭。同时,药物化学系有两个化学生物学职位空缺,但缺乏启动资金。获得初级教师的启动资金对于我们继续在UCSF建立世界一流的化学生物学团队至关重要。
英文摘要
DESCRIPTION (provided by applicant): The long-term objective of this proposal is to build a world-class Chemical Biology group at UCSF. Towards that goal, we aim to recruit a new faculty member to strengthen and expand the Chemical Biology group in the Department of Pharmaceutical Chemistry at UCSF. Science at the interface between chemistry and biology has been the core strength of our department. The Chemical Biology group at UCSF develops chemical tools and technologies to address critical biological problems involved in health care. UCSF has made a long-term commitment to develop and nurture the Chemical Biology group because of the major impact this field will have on future biomedical science and pharmaceutical applications. The recruitment process will be done using specific university mandated procedures and policies that emphasize a fair and open search to find the most highly qualified individual. Available startup funds for the hiring of new faculty have been severely curtailed due to the recent economic situation. Funds from the state and private donors alike are drying up. Meanwhile, the Dept of Pharmaceutical Chemistry has two open chemical biology positions but lacks start-up funds for these positions. Obtaining start-up funding for junior faculty is critical for us to continue to build a world-class Chemical Biology group here at UCSF.
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Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolution
Discovering how oncogenes remodel the surfaceome of cells
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