Optimising rotavirus vaccine effectiveness in Aboriginal children: a double blinded randomised trial of rotavirus vaccine given to infants 6 to 12 months old.

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Rotavirus is major cause of diarrhoeal illness in children. A vaccine to protect against rotavirus was introduced into Australia in 2006/7. Unfortunately vaccine protection is lowest in those in whom disease rates are highest, including Aboriginal infants in the Northern Territory. This trial will investigate if offering an additional dose of vaccine between 6 to 12 months is an effective way to improve vaccine protection and thereby reduce this disease disparity.