Aspen Perinatal Biology Conference

描述（由申请人提供）：本申请要求2010年8月28日至31日的白杨围产期生物学会议的支持资金。该会议每3年举办一次，主题包括宫内应激及其对胎盘发育和胎儿结局的影响。它的重点是确定围产期机制，在怀孕期间和胎儿适应母亲的疾病，并了解母亲/胎儿的健康和胎儿编程对后代的长期后果具有广泛的意义。 生长受限的胎儿出生时患高血压、糖尿病和肥胖症的风险增加。最近的研究已经确定了改变营养（无论是不足和过度喂养的母亲），缺氧，妊娠糖尿病，先兆子痫，药物暴露作为宫内应激源，改变特定的细胞机制，导致胎儿的直接后果和持久的影响，通过胎儿编程到成年。由于围产医学是一个多学科领域，会议的目标是汇集基础科学家和围产学家讨论有助于正常和改变胎儿结局的母体，胎盘和胎儿机制。 拟议的2.5天会议分为3个全体会议幻灯片会议，1个主题演讲，2个海报会议和2个研讨会讲座。会议的4个具体目标是：1）了解怀孕期间与母体适应相关的细胞机制，2）讨论当前对胎盘功能和胎儿成熟重要的机制，3）了解不良宫内环境对胎儿发育的相互作用，以及4）确定有助于胎盘/胎儿适应不良妊娠条件的关键因素。3次全体会议将包括以下主题：1）导致宫内应激的母体疾病，2）营养运输/内分泌产生的胎盘机制，以及3）胎儿适应机制。演讲者将包括1）资深研究人员，在怀孕期间的母体，胎盘和胎儿适应机制领域建立良好，2）年轻的研究人员，开始在生殖医学领域取得成功，3）博士后和研究生。海报会议将为年轻的调查人员提供一种与与会者直接互动的形式。重点讲座将是“胎盘血管生成的机制”，这将有广泛的兴趣围产期生物学领域。研讨会的讲座将解决“胎盘成像技术”和“表观遗传机制的分子调控”。本次会议的基础科学家和临床医生，其广泛的兴趣在于了解不良妊娠结局的机制，预计将产生新的想法，如何解决宫内应激在全球健康问题，如肥胖，糖尿病和心血管疾病的影响。 公共卫生相关性：本申请要求资金支持2010年8月28日至31日的白杨围产期生物学会议。这将是一个3D会议，分为3个全体会议幻灯片会议，1个主题演讲，2个海报会议和2个研讨会讲座。由于围产医学是一个多学科领域，会议的目标是汇集基础科学家和围产学家讨论宫内环境对母体，胎盘和胎儿机制的影响，这些机制有助于改变胎儿结局。

DESCRIPTION (provided by applicant): This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This Conference is organized every 3 years to encompass topics related to intrauterine stress and its impact on placental development and fetal outcomes. Its focus is to identify perinatal mechanisms that link maternal illnesses during pregnancy and fetal adaptations and has broad implication for understanding maternal/fetal health and the long term consequences of fetal programming on the offspring. Growth restricted fetuses are born with an increased risk of hypertension, diabetes, and obesity. Recent studies have now identified altered nutrition (both the under- and overfed mother), hypoxia, gestational diabetes, preeclampsia, and drug exposure as intrauterine stressors that alter specific cellular mechanisms leading to both immediate consequences in the fetus and lasting effects into adulthood through fetal programming. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the maternal, placental and fetal mechanisms that contribute to both normal and altered fetal outcomes. The proposed 2.5 day conference is organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. The 4 specific goals of the conference are: 1) to understand the cellular mechanisms associated with maternal adaptations during pregnancy, 2) to discuss the current mechanisms important in placental function and fetal maturation, 3) to understand the interaction of adverse intrauterine environments on fetal development, and 4) to identify key factors important in contributing to placental/fetal adaptations to adverse pregnancy conditions. The 3 Plenary Sessions will include topics on 1) Maternal Conditions Causing Intrauterine Stress, 2) Placental Mechanisms of Nutrient Transport/Endocrine Production, and 3) Fetal Adaptive Mechanisms. Speakers will include 1) senior investigators, well established in their fields of maternal, placental and fetal mechanisms of adaptation during pregnancy, 2) young investigators, beginning to forge a successful career in reproductive medicine, and 3) postdocs and graduate students. Poster sessions will provide young investigators a format for direct interaction with conferees. The key note lecture will be "Mechanisms of Placental Angiogenesis", which will have broad interest to the field of perinatal biology. The Workshop Lectures will address "Placental Imaging Techniques" and "Molecular Regulation of Epigenetic Mechanisms". This Conference of basic scientists and clinicians, whose broad interests lie in understanding the mechanisms underlying adverse pregnancy outcomes, is expected to generate new ideas on how to address the impact of intrauterine stress in global health issues such as obesity, diabetes, and cardiovascular disease. PUBLIC HEALTH RELEVANCE: This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This will be a 3d Conference organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the effects of a stressed intrauterine environment on maternal, placental and fetal mechanisms that contribute to altered fetal outcomes.