Aspen Perinatal Biology Conference

阿斯彭围产期生物学会议

• 批准号: 8004491
• 负责人: LOREN P THOMPSON
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8004491
• 关键词: Address; Adult; Biology; Cardiovascular Diseases; Diabetes Mellitus; Drug Exposure; Educational workshop; Endocrine; Environment; Epigenetic Process; Fetal Development; Fetus; Funding; Gestational Diabetes; Goals; Growth; Health; Hypertension; Hypoxia; Imaging Techniques; Link; Medicine; Molecular; Mothers; Nutrient; Obesity; Outcome; Perinatal; Placentation; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Production; Regulation; Reproductive Medicine; Request for Applications; Research Personnel; Risk; Scientist; Slide; Stress; angiogenesis; career; fetal; fetal programming; forging; global health; graduate student; interest; lecture notes; lectures; multidisciplinary; nutrition; offspring; posters; public health relevance; stressor; symposium

DESCRIPTION (provided by applicant): This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This Conference is organized every 3 years to encompass topics related to intrauterine stress and its impact on placental development and fetal outcomes. Its focus is to identify perinatal mechanisms that link maternal illnesses during pregnancy and fetal adaptations and has broad implication for understanding maternal/fetal health and the long term consequences of fetal programming on the offspring. Growth restricted fetuses are born with an increased risk of hypertension, diabetes, and obesity. Recent studies have now identified altered nutrition (both the under- and overfed mother), hypoxia, gestational diabetes, preeclampsia, and drug exposure as intrauterine stressors that alter specific cellular mechanisms leading to both immediate consequences in the fetus and lasting effects into adulthood through fetal programming. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the maternal, placental and fetal mechanisms that contribute to both normal and altered fetal outcomes. The proposed 2.5 day conference is organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. The 4 specific goals of the conference are: 1) to understand the cellular mechanisms associated with maternal adaptations during pregnancy, 2) to discuss the current mechanisms important in placental function and fetal maturation, 3) to understand the interaction of adverse intrauterine environments on fetal development, and 4) to identify key factors important in contributing to placental/fetal adaptations to adverse pregnancy conditions. The 3 Plenary Sessions will include topics on 1) Maternal Conditions Causing Intrauterine Stress, 2) Placental Mechanisms of Nutrient Transport/Endocrine Production, and 3) Fetal Adaptive Mechanisms. Speakers will include 1) senior investigators, well established in their fields of maternal, placental and fetal mechanisms of adaptation during pregnancy, 2) young investigators, beginning to forge a successful career in reproductive medicine, and 3) postdocs and graduate students. Poster sessions will provide young investigators a format for direct interaction with conferees. The key note lecture will be "Mechanisms of Placental Angiogenesis", which will have broad interest to the field of perinatal biology. The Workshop Lectures will address "Placental Imaging Techniques" and "Molecular Regulation of Epigenetic Mechanisms". This Conference of basic scientists and clinicians, whose broad interests lie in understanding the mechanisms underlying adverse pregnancy outcomes, is expected to generate new ideas on how to address the impact of intrauterine stress in global health issues such as obesity, diabetes, and cardiovascular disease. PUBLIC HEALTH RELEVANCE: This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This will be a 3d Conference organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the effects of a stressed intrauterine environment on maternal, placental and fetal mechanisms that contribute to altered fetal outcomes.

描述（由申请人提供）：本申请请求资金支持 2010 年 8 月 28 日至 31 日举行的阿斯彭围产期生物学会议。该会议每 3 年举办一次，涵盖与宫内应激及其对胎盘发育和胎儿结局影响相关的主题。其重点是确定将怀孕期间孕产妇疾病与胎儿适应联系起来的围产期机制，并且对于了解孕产妇/胎儿健康以及胎儿编程对后代的长期影响具有广泛的意义。 生长受限的胎儿出生时患高血压、糖尿病和肥胖的风险增加。最近的研究现已确定营养改变（母亲营养不足和过度）、缺氧、妊娠糖尿病、先兆子痫和药物暴露是宫内应激源，这些应激源会改变特定的细胞机制，从而对胎儿产生直接影响，并通过胎儿编程对成年期产生持久影响。由于围产期医学是一个多学科领域，会议的目标是将基础科学家和围产期学家聚集在一起，讨论有助于正常和改变胎儿结局的母体、胎盘和胎儿机制。 拟议的为期 2.5 天的会议分为 3 场全体幻灯片会议、1 场主题演讲、2 场海报会议和 2 场研讨会讲座。会议的 4 个具体目标是：1）了解与妊娠期间母亲适应相关的细胞机制，2）讨论当前对胎盘功能和胎儿成熟重要的机制，3）了解不利的宫内环境对胎儿发育的相互作用，4）确定有助于胎盘/胎儿适应不良妊娠条件的重要因素。 3 场全体会议将包括以下主题：1) 引起宫内应激的母体状况，2) 营养运输/内分泌生产的胎盘机制，以及 3) 胎儿适应机制。演讲者将包括 1) 在孕产妇、胎盘和胎儿适应机制领域拥有丰富经验的资深研究人员，2) 开始在生殖医学领域取得成功的职业生涯的年轻研究人员，以及 3) 博士后和研究生。海报会议将为年轻的研究者提供一种与与会者直接互动的方式。主旨演讲将是“胎盘血管生成的机制”，这将引起围产期生物学领域的广泛兴趣。研讨会讲座将讨论“胎盘成像技术”和“表观遗传机制的分子调控”。这次会议由基础科学家和临床医生组成，他们的广泛兴趣在于了解不良妊娠结局的机制，预计将就如何解决子宫内压力对肥胖、糖尿病和心血管疾病等全球健康问题的影响产生新的想法。 公共卫生相关性：本申请请求资金支持 2010 年 8 月 28 日至 31 日举行的阿斯彭围产期生物学会议。这将是一次 3d 会议，分为 3 个全体幻灯片会议、1 个主题演讲、2 个海报会议和 2 个研讨会讲座。由于围产期医学是一个多学科领域，会议的目标是将基础科学家和围产期学家聚集在一起，讨论紧张的宫内环境对母亲、胎盘和胎儿机制的影响，从而导致胎儿结局的改变。