2010 Chemistry and Biology of Tetrapyrroles Gordon Research Conference

2010年四吡咯化学与生物学戈登研究会议

• 批准号: 7896921
• 负责人: Angela Wilks
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7896921
• 关键词: Address; Agriculture; Animals; Area; Biochemistry; Biological; Biology; Biophysics; Biotechnology; Cells; Chemistry; Clinical; Collaborations; Communities; Development; Discipline; Disease; Erythroid; Fostering; Gene Expression Regulation; Generations; Heme; Image; Inborn Genetic Diseases; Malignant Neoplasms; Medical; Metabolism; Microbiology; Oxidative Stress; Participant; Pathogenesis; Plants; Porphyrins; Reaction; Regulation; Research; Research Personnel; Role; Scientist; Signal Transduction; Solar Energy; System; Tetrapyrroles; Therapeutic; Time; Translational Research; frontier; human disease; interest; meetings; novel; planetary Atmosphere; porphyrin metabolism; posters; programs; symposium; trafficking; uptake

DESCRIPTION (provided by applicant): This application was submitted in support of the 2010 Chemistry and Biology of Tetrapyrroles GRC. The meeting, which is limited to 135 participants, is unique in the field of tetrapyrroles, as there is no other meeting with a similar tradition of broad disciplinary participation. The program will focus on recent advances in tetrapyrrole biology and chemistry including the rapidly growing areas of tetrapyrroles in energy generation in plants and solar energy cells, the emerging role of tetrapyrroles in cell signaling, regulation and human disease; tetrapyrrole trafficking in prokaryotic and eukaryotic systems, and novel mechanistic reactions, both biological and synthetic. The meeting will highlight key areas of progress in the field in which the chemistry and biology inform or advance new medical, agricultural or technological developments. This proposal will address two specific aims: 1) To provide a forum for the discussion of cutting edge unpublished research between basic and clinical scientists, who have a common interest in the chemistry and biology of tetrapyrrole molecules. 2) To bring together and promote the exchange of ideas between established and new investigators from a wide variety of scientific disciplines (e.g., chemistry, biophysics, biochemistry, plant and animal biology, microbiology, and biotechnology) with their clinical counterparts; by providing ample discussion time following formal presentations; holding poster sessions that serve as a focus for the discussion of common interests; and, by fostering a collegial atmosphere that promotes translational research ideas and collaborations. Topics of interest to the medical community include inborn errors of heme metabolism and erythroid development, heme degradation and oxidative stress, heme uptake and utilization in bacterial pathogenesis, and the role of tetrapyrroles as imaging and therapeutic molecules. This meeting will explore the frontiers of tetrapyrrole research as it relates to inbornerrors of porphyrin metabolism, gene regulation and disease. In addition important newresearch in the area of synthetic porphyrins as imaging and therapeutic molecules indiseases such as cancer will be presented.

描述（由申请人提供）：此申请是为了支持2010年四吡咯的化学和生物学GRC的生物学。这次会议仅限于135名参与者，在四吡咯领域是独一无二的，因为没有其他会议具有类似的广泛纪律参与的传统。该计划将重点介绍四吡咯生物学和化学的最新进展，包括植物和太阳能细胞能量产生中四吡咯的快速生长的领域，四吡咯在细胞信号传导，调节和人类疾病中的新兴作用；四吡咯对原核生物和真核系统的运输以及生物学和合成的新机械反应。该会议将重点介绍化学和生物学为新的医学，农业或技术发展提供信息或推进该领域的关键领域。该提案将针对两个具体的目的：1）为讨论基础科学家和临床科学家之间未发表研究的讨论提供论坛，他们对四吡咯分子的化学和生物学具有共同的兴趣。 2）从各种科学学科（例如，化学，生物物理学，生物化学，动植物生物学，微生物学和生物技术学）汇总并促进既定研究者和新研究者之间思想的交流并促进思想的交流；通过在正式演讲后提供充足的讨论时间；举行海报会议，是讨论共同利益的重点；并且，通过营造一种促进翻译研究思想和合作的合作氛围。医学界感兴趣的主题包括血红素代谢和红细胞发育的先天错误，血红素降解和氧化应激，血红素摄取和在细菌发病机理中的摄取和利用以及四吡咯作为成像和治疗分子的作用。 这次会议将探索与卟啉代谢，基因调节和疾病的生存有关的四吡咯研究的前沿。此外，将提出合成卟啉领域的重要纽研究研究，作为成像和治疗分子（例如癌症）。