2010 Chemistry and Biology of Tetrapyrroles Gordon Research Conference

描述（由申请人提供）：本申请是为了支持2010年四吡咯GRC的化学和生物学而提交的。这次会议仅限135名与会者，在四吡咯领域是独一无二的，因为没有其他会议具有广泛学科参与的类似传统。该计划将重点关注四吡咯生物学和化学的最新进展，包括四吡咯在植物和太阳能电池中能源产生的快速增长领域，四吡咯在细胞信号传导，调节和人类疾病中的新兴作用;原核和真核系统中的四吡咯贩运，以及生物和合成的新型机械反应。会议将突出化学和生物学为新的医学、农业或技术发展提供信息或推进的领域的关键进展领域。该提案将解决两个具体目标：1）为基础和临床科学家之间讨论前沿未发表的研究提供一个论坛，这些科学家对四吡咯分子的化学和生物学具有共同兴趣。2)汇集并促进来自各种科学学科（例如，通过以下方式，我们可以与临床同行进行交流（包括化学、生物物理学、生物化学、动植物生物学、微生物学和生物技术）;在正式演讲后提供充足的讨论时间;举办海报会议，作为共同兴趣讨论的焦点;以及培养促进转化研究理念和合作的大学氛围。医学界感兴趣的主题包括血红素代谢和红细胞发育的先天性缺陷，血红素降解和氧化应激，细菌发病机制中血红素的摄取和利用，以及四吡咯作为成像和治疗分子的作用。 本次会议将探讨四吡咯研究的前沿，因为它涉及到卟啉代谢，基因调控和疾病的inbornerrors。此外，重要的新研究领域的合成卟啉作为成像和治疗分子的疾病，如癌症将提出.

DESCRIPTION (provided by applicant): This application was submitted in support of the 2010 Chemistry and Biology of Tetrapyrroles GRC. The meeting, which is limited to 135 participants, is unique in the field of tetrapyrroles, as there is no other meeting with a similar tradition of broad disciplinary participation. The program will focus on recent advances in tetrapyrrole biology and chemistry including the rapidly growing areas of tetrapyrroles in energy generation in plants and solar energy cells, the emerging role of tetrapyrroles in cell signaling, regulation and human disease; tetrapyrrole trafficking in prokaryotic and eukaryotic systems, and novel mechanistic reactions, both biological and synthetic. The meeting will highlight key areas of progress in the field in which the chemistry and biology inform or advance new medical, agricultural or technological developments. This proposal will address two specific aims: 1) To provide a forum for the discussion of cutting edge unpublished research between basic and clinical scientists, who have a common interest in the chemistry and biology of tetrapyrrole molecules. 2) To bring together and promote the exchange of ideas between established and new investigators from a wide variety of scientific disciplines (e.g., chemistry, biophysics, biochemistry, plant and animal biology, microbiology, and biotechnology) with their clinical counterparts; by providing ample discussion time following formal presentations; holding poster sessions that serve as a focus for the discussion of common interests; and, by fostering a collegial atmosphere that promotes translational research ideas and collaborations. Topics of interest to the medical community include inborn errors of heme metabolism and erythroid development, heme degradation and oxidative stress, heme uptake and utilization in bacterial pathogenesis, and the role of tetrapyrroles as imaging and therapeutic molecules. This meeting will explore the frontiers of tetrapyrrole research as it relates to inbornerrors of porphyrin metabolism, gene regulation and disease. In addition important newresearch in the area of synthetic porphyrins as imaging and therapeutic molecules indiseases such as cancer will be presented.