2010 Chemistry and Biology of Tetrapyrroles Gordon Research Conference

描述(申请人提供)：本申请是为支持2010年四元角色化学与生物学GRC而提交的。这次会议的与会者人数限制为135人，这在四方角色领域是独一无二的，因为没有其他会议具有类似的广泛参加纪律的传统。该计划将侧重于四吡咯生物学和化学方面的最新进展，包括四吡咯在植物和太阳能电池中产生能量的快速增长领域，四吡咯在细胞信号、调节和人类疾病中的新作用，四吡咯在原核和真核系统中的运输，以及生物和合成的新型机械反应。会议将重点介绍化学和生物学为新的医疗、农业或技术发展提供信息或推动其发展的关键领域。这项提议将解决两个具体目标：1)为基础和临床科学家之间讨论尖端未发表的研究提供一个论坛，他们对四吡咯分子的化学和生物学有共同的兴趣。2)汇聚和促进来自各种科学学科(如化学、生物物理学、生物化学、动植物生物学、微生物学和生物技术)的现有研究人员和新研究人员与临床同行交流思想；在正式陈述之后提供充足的讨论时间；举办海报会议，作为讨论共同利益的焦点；以及，通过培养促进翻译研究想法和合作的合议氛围。医学界感兴趣的话题包括血红素代谢和红系发育的先天缺陷，血红素的降解和氧化应激，血红素在细菌发病机制中的吸收和利用，以及四吡咯作为成像和治疗分子的作用。 这次会议将探索四吡咯研究的前沿领域，因为它与卟啉代谢、基因调控和疾病的内在联系有关。此外，还将介绍在合成卟啉作为癌症等疾病的成像和治疗分子方面的重要新研究。

DESCRIPTION (provided by applicant): This application was submitted in support of the 2010 Chemistry and Biology of Tetrapyrroles GRC. The meeting, which is limited to 135 participants, is unique in the field of tetrapyrroles, as there is no other meeting with a similar tradition of broad disciplinary participation. The program will focus on recent advances in tetrapyrrole biology and chemistry including the rapidly growing areas of tetrapyrroles in energy generation in plants and solar energy cells, the emerging role of tetrapyrroles in cell signaling, regulation and human disease; tetrapyrrole trafficking in prokaryotic and eukaryotic systems, and novel mechanistic reactions, both biological and synthetic. The meeting will highlight key areas of progress in the field in which the chemistry and biology inform or advance new medical, agricultural or technological developments. This proposal will address two specific aims: 1) To provide a forum for the discussion of cutting edge unpublished research between basic and clinical scientists, who have a common interest in the chemistry and biology of tetrapyrrole molecules. 2) To bring together and promote the exchange of ideas between established and new investigators from a wide variety of scientific disciplines (e.g., chemistry, biophysics, biochemistry, plant and animal biology, microbiology, and biotechnology) with their clinical counterparts; by providing ample discussion time following formal presentations; holding poster sessions that serve as a focus for the discussion of common interests; and, by fostering a collegial atmosphere that promotes translational research ideas and collaborations. Topics of interest to the medical community include inborn errors of heme metabolism and erythroid development, heme degradation and oxidative stress, heme uptake and utilization in bacterial pathogenesis, and the role of tetrapyrroles as imaging and therapeutic molecules. This meeting will explore the frontiers of tetrapyrrole research as it relates to inbornerrors of porphyrin metabolism, gene regulation and disease. In addition important newresearch in the area of synthetic porphyrins as imaging and therapeutic molecules indiseases such as cancer will be presented.