2010 and 2012 Membrane Transport Proteins

描述（由申请人提供）：所有生物体都依赖于无机离子和有机溶质跨细胞膜的转运。一个极其多样化的膜转运蛋白集合共同解释了各种分子的通量，包括糖、氨基酸、代谢物、肽、神经递质、毒素和药物。此外，膜转运蛋白不仅有助于从营养吸收到氮代谢、肾功能和突触传递的生理学重要过程，而且在从癌症到精神疾病的许多人类疾病中发挥关键作用。然而，与膜蛋白和转运蛋白的分析相关的技术限制，特别是以前限制了我们对这些迷人的和重要的蛋白质的理解。另一方面，结构生物学和功能分析的最新进展现在使研究人员能够在生理背景下解决运输的分子基础，促进了该领域的快速发展。本次会议的长期目标是增加我们对膜转运蛋白的分子机制，生理作用和对疾病的贡献的理解。本申请寻求分别于2010年和2012年举行的第7届和第8届戈登研究会议（GRC）的部分支持。为了包括一个以运输为重点的大型欧洲社区，会议决定在欧洲和美国场地之间交替举行：会议将于2010年（8月15日至20日）在新英格兰大学举行，并暂定于2012年在意大利的Il Ciocco举行。这次会议汇集了研究人员在许多不同的系统与各种各样的实验方法。除了提供对最新研究的接触外，它还将促进思想交流，促进跨领域和方法学科合作的发展。计划的会议将涵盖广泛的膜转运蛋白，包括离子泵，ABC（ATP结合盒）转运蛋白，氨基酸转运蛋白，细胞内转运蛋白，神经递质转运蛋白和离子通道。此外，演讲者还将描述从结构生物学和生物物理学到动物模型和遗传学的各种技术和方法。两个晚上的海报会议将允许所有参与者分享他们的工作成果。会议将以一个全体会议演讲结束，该演讲将膜转运蛋白的分子和细胞分析与生理学和疾病相结合。 公共卫生相关性：该申请要求部分支持2010年和2012年的两个为期五天的戈登研究会议，该会议将重点关注正常生理学和疾病中的膜转运蛋白。为了促进我们对这些迷人而重要但神秘的蛋白质的理解，会议将汇集来自广泛领域的研究人员，采用不同的实验方法。因此，这些会议将传播该领域的最新发展，并促进可能没有交叉的调查人员之间的合作。

DESCRIPTION (provided by applicant): All living organisms depend on the transport of inorganic ions and organic solutes across cellular membranes. An extremely diverse collection of membrane transport proteins together account for the flux of a wide range of molecules, including sugars, amino acids, metabolites, peptides, neurotransmitters, toxins and drugs. Further, membrane transport proteins not only contribute to physiologically important processes from nutrient absorption to nitrogen metabolism, renal function and synaptic transmission, but also play a key role in many human diseases from cancer to mental illness. However, technical limitations associated with the analysis of membrane proteins and transporters in particular has previously limited progress in our understanding of these fascinating and important proteins. On the other hand, recent advances in structural biology and functional analysis now enable investigators to address the molecular basis of transport in a physiological context, spurring rapid growth in the field. The long-term objective of this conference is to increase our understanding of the molecular mechanism, physiological role and contribution to disease of membrane transport proteins. This application seeks partial support for the 7th and 8th Gordon Research Conference (GRC) on Membrane Transport Proteins to be held in 2010 and 2012, respectively. To include a large European community focusing on transporters, it has been decided to alternate between European and US venues: the conference will return to the University of New England in 2010 (August 15- 20) and tentatively to Il Ciocco, Italy in 2012. This conference brings together researchers working on many different systems with a wide variety of experimental approaches. In addition to providing exposure to recent research, it will thus foster the exchange of ideas and promote the development of collaborations across fields and methodological disciplines. The sessions planned will cover a broad spectrum of membrane transport proteins including ion pumps, ABC (ATP binding cassette) transporters, amino acid transporters, intracellular transporters, neurotransmitter transporters and ion channels. In addition, the speakers will describe a diversity of techniques and approaches, from structural biology and biophysics to animal models and genetics. Two evening poster sessions will allow all the participants to share the results of their work. The conferences will conclude with a plenary lecture that integrates work on the molecular and cellular analysis of membrane transport proteins with physiology and disease. PUBLIC HEALTH RELEVANCE: This application requests partial support for 2 five-day Gordon Research Conferences in 2010 and 2012, which will focus on membrane transport proteins in normal physiology and disease. To promote our understanding of these fascinating and important but enigmatic proteins, the conferences will bring together investigators from a wide range of fields with diverse experimental approaches. As a result, the conferences will disseminate recent developments in the field, and foster collaboration between investigators who might not otherwise intersect.