CRYSTALLOGRAPHIC STUDIES OF MEDICALLY AND BIOLOGICALLY SIGNIFICANT PROTEIN MOLEC

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该实验室作为国家结构生物学中心获得资助，自1999年以来有效利用了SSRL光束线，收集了50多条（自2002年以来35条）。我们将晶体装在专为SSRL自动换样机器人设计的低温杜瓦瓶中运输，并充分利用SSRL的远程数据收集功能。项目包括涉及细菌和病毒病原体，毒力因子和免疫调节剂的高通量结构基因组学计划，以及与病毒组装和复制，蛋白质微晶，抗生素耐药性机制等相关的各种其他项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This laboratory is funded as a national centre for structural biology, and has made effective use of SSRL beamlines since 1999, collecting more than 50 (35 since 2002). We ship the crystals in cryo-Dewars, in the cassettes designed for the SSRL automatic sample changing robotics, and make good use of the SSRL remote data collection capabilities. Projects include high throughput structural genomics programs involving bacterial and viral pathogens, virulence factors and immune modulators, and a variety of other projects related to viral assembly and replication, protein microcrystals, mechanisms of antibiotic resistance etc. Our robotic crystallization facility has markedly increased success rates, and gives a steady stream of new crystals.