CRYSTALLOGRAPHIC STUDIES OF MEDICALLY AND BIOLOGICALLY SIGNIFICANT PROTEIN MOLEC

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该实验室作为国家结构生物学中心得到资助，自1999年以来一直有效利用SSRL光束线，收集了50多条(自2002年以来为35条)。我们将晶体装在低温杜瓦瓶中，装在为SSRL自动换样机器人设计的盒式磁带中，并充分利用SSRL的远程数据收集能力。项目包括涉及细菌和病毒病原体、毒力因子和免疫调节剂的高通量结构基因组学计划，以及与病毒组装和复制、蛋白质微晶体、抗生素耐药性机制等相关的各种其他项目。我们的机器人结晶设施显著提高了成功率，并提供了稳定的新晶体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This laboratory is funded as a national centre for structural biology, and has made effective use of SSRL beamlines since 1999, collecting more than 50 (35 since 2002). We ship the crystals in cryo-Dewars, in the cassettes designed for the SSRL automatic sample changing robotics, and make good use of the SSRL remote data collection capabilities. Projects include high throughput structural genomics programs involving bacterial and viral pathogens, virulence factors and immune modulators, and a variety of other projects related to viral assembly and replication, protein microcrystals, mechanisms of antibiotic resistance etc. Our robotic crystallization facility has markedly increased success rates, and gives a steady stream of new crystals.