INVOLVEMENT OF CALCIUM-INDEPENDENT PHOSPHOLIPASE A2? IN HIGH GLUCOSE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们在此报道，钙非依赖性磷脂酶A2在高糖诱导的RhoA/Rho-Kinase/CPI-17激活和糖尿病相关的血管平滑肌过度收缩中起关键作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We report here that calcium-independent phospholipase A2¿ (iPLA2¿) plays a critical role in high glucose-induced RhoA/Rho-kinase/CPI-17 activation and diabetes-associated vascular smooth muscle hypercontractility.