CHARACTERIZATION OF ANTIGENIC PEPTIDES PRESENTED BY I-AG7
I-AG7 呈现的抗原肽的表征
基本信息
- 批准号:8168793
- 负责人:
- 金额:$ 0.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-03-10 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:CatalogingCatalogsComputer Retrieval of Information on Scientific Projects DatabaseFundingGoalsGrantHistocompatibility Antigens Class IIInbred NOD MiceInstitutionMass Spectrum AnalysisMouse Cell LinePeptidesPost-Translational Protein ProcessingProteinsResearchResearch PersonnelResourcesSourceUnited States National Institutes of Healthimprovedinsulinomatechnique development
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The goal of this project is to identify peptides presented by the diabetogenic MHC class II molecule I-Ag7 from NOD mice. Studies will use both NOD mice and cell lines derived from insulinomas. The study will extend to cover the effect of loading, posttranslational modification, and challenge by foreign peptides and proteins. Mass spectrometry will be used to sequence and catalog these peptides and the development of techniques to improve sensitivity and analysis will be pursued.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
本项目的目标是鉴定NOD小鼠致糖尿病MHC II类分子I-Ag 7所提呈的肽。 研究将使用NOD小鼠和来自胰岛素瘤的细胞系。 这项研究将扩展到包括负载,翻译后修饰和外来肽和蛋白质的挑战的影响。 质谱法将被用来对这些肽进行测序和编目,并将继续开发提高灵敏度和分析的技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('EMIL Raphael UNANUE', 18)}}的其他基金
Identification of relevant peptides involved in the initiation and progression of autoimmune diabetes
鉴定参与自身免疫性糖尿病发生和进展的相关肽
- 批准号:
10246429 - 财政年份:2018
- 资助金额:
$ 0.62万 - 项目类别:
Identification of relevant peptides involved in the initiation and progression of autoimmune diabetes
鉴定参与自身免疫性糖尿病发生和进展的相关肽
- 批准号:
9689765 - 财政年份:2018
- 资助金额:
$ 0.62万 - 项目类别:
AUTOIMMUNE DIABETES: EARLY EVENTS IN ISLETS OF LANGERHANS
自身免疫性糖尿病:朗格汉斯岛的早期事件
- 批准号:
9197630 - 财政年份:2015
- 资助金额:
$ 0.62万 - 项目类别:
CHARACTERIZATION OF ANTIGENIC PEPTIDES PRESENTED BY I-AG7
I-AG7 呈现的抗原肽的表征
- 批准号:
8361393 - 财政年份:2011
- 资助金额:
$ 0.62万 - 项目类别:
IDENTIFICATION OF MODIFIED AND NATURAL HEL PEPTIDE FRAGMENTS PRESENTED BY MHC
MHC 呈现的修饰和天然 HEL 肽片段的鉴定
- 批准号:
8361330 - 财政年份:2011
- 资助金额:
$ 0.62万 - 项目类别:
IDENTIFICATION OF MODIFIED AND NATURAL HEL PEPTIDE FRAGMENTS PRESENTED BY MHC
MHC 呈现的修饰和天然 HEL 肽片段的鉴定
- 批准号:
8168678 - 财政年份:2010
- 资助金额:
$ 0.62万 - 项目类别:
PEPTIDES IDENTIFIED FROM THE TYPE I DIABETES ASSOCIATED MHC CLASS I-H2-KD
从 I 型糖尿病相关 MHC I-H2-KD 类中鉴定出的肽
- 批准号:
8168690 - 财政年份:2010
- 资助金额:
$ 0.62万 - 项目类别:
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