PARKINSON'S DISEASE NEUROPROTECTION CLINICAL TRIALS: CLINICAL CENTER

描述(申请人提供)：帕金森氏病(PD)是一种常见的进行性神经退行性疾病。最近的研究已经提出了一些潜在的神经保护剂，但还需要进行大规模的临床试验来确定有效性。这只能由经验丰富的PD试验中心组成的财团来完成。这项提议的目的是概述我们成为中心的经验、兴趣和兴奋，以及与其他网站合作的意愿。卡尔加里大学的运动障碍项目是南艾伯塔省唯一的PD诊所，为近200万人口提供服务。其主要目标是为帕金森病(PD)患者提供与临床研究相结合的全面临床护理。临床医生和护士协调员在协作临床试验方面拥有12年的可靠记录。该诊所以一贯的高招聘人员和高质量的参与而享誉国际。其中一个优势是将临床护理与临床研究整合在一个单元中。无论患者是否正在接受临床护理和/或参与临床试验，他们都将经常由同一名神经科医生和护士协调员长期护理。由于以下因素，拟议试验的招募将很容易实现：1)大型转诊基地2)在该地区没有竞争的PD中心3)建立的数据库，包括3000名患者4)与社区和专科神经病学家的合作关系5)与PD非专业组织的密切工作关系，包括南艾伯塔省帕金森学会和加拿大帕金森协会6)与卡尔加里大学和非专业组织链接的临床网站。通过组织已建立的计划，加强了对已确定的患者群体的维护。1)证明了患者对我们全面护理计划的忠诚度和鉴赏力2)临床研究和临床计划的整合3)神经科医生和护士临床医生的持续参与4)患者通过电子邮件和电话与临床成员进行轻松而规律的沟通。该诊所得到卡尔加里大学和卡尔加里卫生区的大力支持，以实现其为PD患者提供全面、综合的最先进项目的目标，并推进这一领域的研究。

DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a common, progressive, neurodegenerative disorder. Recent studies have suggested a number of potential neuroprotective agents, but a large clinical trial would be needed to determine effectiveness. This could only be accomplished by a consortium of experienced PD trial centers. The aim of this proposal is to outline our experience, interest and excitement in becoming a center, and willingness to cooperate with other sites. The Movement Disorders Program at the University of Calgary is the only PD clinic in Southern Alberta, serving a population of almost 2 million. Its major aim is to provide comprehensive clinical care integrated with clinical research to Parkinson's disease (PD) patients. Clinic physicians and nurse coordinators have a proven track record of 12 years of experience in collaborative clinical trials. The clinic has an international reputation for being consistently a high recruiter, and for providing high quality participation. One of the strengths is the integration of clinical care with clinical research in one unit. Patients will frequently be cared for by the same neurologist and nurse coordinator on a long-term basis, whether they are receiving clinical care and/or participating in clinical trials. Recruitment for the proposed trials will be easily achieved due to the following factors: 1) large referral base 2) no competing PD centres in the area 3) established database including 3000 patients 4) collegial working relationship with community and sub-specialty neurologists 5) close working relationship with PD lay organizations, including Parkinson's Society of Southern Alberta, and Parkinson Society Canada 6) clinic website linked to University of Calgary and lay organizations. Maintenance of the identified patient population is enhanced by the organization of the established program. 1) proven loyalty and appreciation of patients for our comprehensive care program 2) integration of clinical research and clinical programs 3) continuity of involvement of neurologists and nurse clinicians 4) ease and regularity of patient communication with clinic members via e-mail and phone. The clinic has strong support from the University of Calgary and Calgary Health Region to fulfill its aim of providing comprehensive, integrated state of the art programs to PD patients, and advancing research in this area.