Optimum Thiamine Dose for Treatment and Prevention of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial targeting Aboriginal People.

治疗和预防韦尼克-科尔萨科夫综合征 (WKS) 的最佳硫胺素剂量：针对原住民的随机对照试验。

• 批准号: nhmrc : 1057968
• 负责人: Dr Kylie Dingwall
• 金额: $ 86.27万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimum-thiamine-dose-aboriginal-people/454647
• 关键词: Optimum; Thiamine; Dose; Treatment; Prevention

Wernicke-Korsakoff syndrome (WKS), once thought to be a rare condition, is now known to be common in people with nutritional deficiencies or alcohol dependence. WKS may lead to significant, long-term brain dysfunction with severe effects on work, personal and social function. Whilst effective treatment may greatly reduce severe disability and the human and social costs of this illness, almost no evidence exists on optimal dosing regimens. This project proposes to develop quality evidence for effective treatment of WKS in an Aboriginal setting.

Wernicke-Korsakoff综合征（WKS）曾经被认为是一种罕见的疾病，现在已知在营养缺乏或酒精依赖的人群中很常见。WKS可能导致严重的长期脑功能障碍，对工作，个人和社会功能产生严重影响。虽然有效的治疗可以大大减少这种疾病的严重残疾和人类和社会成本，但几乎没有证据表明存在最佳剂量方案。该项目建议为在土著环境中有效治疗WKS制定高质量的证据。