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Biofeedback of real-time fMRI to control activity in the orbitofrontal cortex

实时功能磁共振成像生物反馈控制眶额皮质活动

基本信息

批准号：
8061656
负责人：
Michelle Hampson
金额：
$ 20.48万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-13 至 2013-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Obsessive-compulsive disorder is a relatively common and debilitating disorder associated with hyperactivity in the orbitofrontal cortex. Current treatments are ineffective for many individuals and the development of new (preferably low-risk) clinical interventions are needed. Furthermore, the neurobiological basis of hyperactivity in orbitofrontal cortex associated with obsessive-compulsive symptoms is not well understood. The proposed research project addresses these issues by developing a protocol to train subjects to control activity in a region of their orbitofrontal cortex associated with contamination-related anxiety using biofeedback of real-time functional magnetic resonance imaging (rt-fMRI) data. Biofeedback of rt-fMRI data is a new technique in which the temporal pattern of activity in a specific region of a subject's brain is provided as a feedback signal to the subject. The subject can experiment with different cognitive strategies to identify those that are effective in influencing brain activity in the region of interest, thereby gaining greater control over the target brain region. The proposed research project examines whether biofeedback of rt-fMRI data can enable healthy subjects to develop greater control over the area of their orbitofrontal cortex associated with contamination-related anxiety. If so, this new technique may yield a low- risk, non-invasive clinical intervention for patients with obsessive-compulsive disorder. In addition, patterns of functional connectivity between the orbitofrontal cortex and other regions of the brain will be examined before and after biofeedback to identify those brain areas whose interactions with the orbitofrontal cortex are related to the ability of subjects to control activity in this area. This will inform our understanding of the network dynamics underlying biofeedback-related changes in orbitofrontal activity patterns. Although this research project is focused on developing a protocol specifically for treating and studying obsessive-compulsive disorder, the methodology has great promise as both a treatment intervention and as a research tool for a broad range of neuropsychiatric disorders. Biofeedback of rt-fMRI data is, however, a highly novel technique, and developmental studies such as the proposed project are needed to realize its full potential. PUBLIC HEALTH RELEVANCE: Real-time brain imaging can provide information regarding activity in specific brain areas almost as it is occurring (with only several seconds delay). By providing people with this information as a feedback signal, we aim to train them to control neural activity in particular regions of their brains and to examine how interactions between brain areas change as a result of such training. The proposed research develops this method as a tool for treating and studying obsessive-compulsive disorder in particular, although it has potential therapeutic and investigative utility for a wide range of mental disorders.

描述（由申请人提供）：强迫症是一种相对常见且使人衰弱的疾病，与眶额皮质过度活跃相关。目前的治疗对许多人无效，需要开发新的（最好是低风险的）临床干预措施。此外，眶额皮质过度活跃与强迫症状相关的神经生物学基础还不清楚。拟议的研究项目通过开发一种协议来解决这些问题，该协议使用实时功能性磁共振成像（rt-fMRI）数据的生物反馈来训练受试者控制与污染相关焦虑相关的眶额皮层区域的活动。rt-fMRI数据的生物反馈是一种新技术，其中受试者大脑特定区域的活动时间模式作为反馈信号提供给受试者。受试者可以用不同的认知策略进行实验，以识别那些有效影响感兴趣区域中的大脑活动的策略，从而获得对目标大脑区域的更大控制。拟议中的研究项目检查rt-fMRI数据的生物反馈是否可以使健康受试者能够更好地控制与污染相关的焦虑相关的眶额皮质区域。如果是这样的话，这项新技术可能会为强迫症患者提供一种低风险、非侵入性的临床干预。此外，在生物反馈之前和之后，将检查眶额皮质与大脑其他区域之间的功能连接模式，以确定与眶额皮质相互作用的大脑区域与受试者控制该区域活动的能力有关。这将使我们了解眶额活动模式中生物反馈相关变化的网络动力学。虽然这个研究项目的重点是开发一个专门用于治疗和研究强迫症的协议，该方法有很大的希望，作为一种治疗干预和作为一种研究工具，广泛的神经精神疾病。然而，rt-fMRI数据的生物反馈是一种非常新颖的技术，需要进行开发研究，如所提出的项目，以实现其全部潜力。公共卫生相关性：实时脑成像可以提供有关特定脑区活动的信息，几乎是在发生时（只有几秒钟的延迟）。通过向人们提供这些信息作为反馈信号，我们的目标是训练他们控制大脑特定区域的神经活动，并检查大脑区域之间的相互作用如何因这种训练而改变。拟议的研究开发了这种方法作为治疗和研究强迫症的工具，特别是，尽管它对广泛的精神障碍具有潜在的治疗和调查效用。