Natural Products in the Prevention of Cancer

描述（由申请人提供）：天然产物为癌症治疗和预防新药的开发提供了多种资源。癌症化学预防被定义为预防、延迟或逆转癌症发生的方法。为了发现和开发新的癌症化学预防剂，许多天然产物研究人员和药物化学家都专注于探索具有生物活性的植物，设计用于检测潜在的癌症预防剂的生物测定和天然产物作为先导分子的分离，以及活性成分的修饰以进一步合成。新的生物活性天然产物化学的最新进展提供了新药物的改进和开发。为了预防癌症等复杂疾病，不同的科学家群体共同努力，从天然资源中开发新的安全药物。为了回顾这一领域的最新进展，并帮助确定未来的道路，我们召集了一批国际知名的癌症预防专家参加研讨会，并介绍他们最近的工作。会议的主要议题将是从天然产品和药用植物开发的潜在化学预防剂。会议将涵盖癌症预防研究领域的临床前、临床和流行病学数据，包括天然化合物或天然产品成分。将有10名特邀发言者在会议上发言。进一步讨论天然产物在癌症预防领域的未来研究方向将是非常有趣的。在研讨会开始时，将提出一个讲座，概述讲座来，强调该领域的挑战，并为诉讼程序来设置的阶段。会议的目的是批判性地评价进展情况，并开始为今后的工作规划路线。每个讲座将包括问题和答案和讨论。在会议结束时，将主持一次圆桌讨论会，与会者将包括每一位发言者和听众。该研讨会将作为北美植物化学学会第50届年会的一部分进行，该年会将于2011年12月10日至14日在夏威夷大岛的科哈拉海岸举行。我们将利用会议组织者聚集的所有资源，确保这次研讨会的成功。观众将是多样化和国际化的。该场地位于市中心，以促进东西方互动。非常优惠的酒店价格已经得到保证，以促进广泛的出席，包括研究生和其他学员。预计与会者将反映广泛的多样性。研讨会的论文集将由Springer出版社出版，名为Topics in Current Chemistry（影响因子5.270; 2009）。每一章以及前言将感谢在会议上的介绍和NIH提供的支持。这将是癌症化学预防领域的里程碑式成就。 公共卫生相关性：预防癌症是减少人类痛苦的安全有效的方法。原则上，癌症化学预防在预防疾病方面可以发挥与疫苗一样的主导作用。然而，尽管这一办法大有希望，但进展受到了阻碍。我们建议组织一次会议，将癌症预防和天然产品研究领域的杰出研究人员聚集在一起。其目的是加强沟通，传播新的发现，准备一个平台，以增加合作，使用和开发新的成分及其衍生物从天然产品作为潜在的癌症预防剂，并探讨和确定障碍和克服这些障碍的方法。天然产品的预防方法是改善公众健康的癌症预防战略的重要组成部分。我们相信，这次会议可能有助于实现NIH的目标，并将提供更好的理解和方法，以减少癌症的发病率和死亡率在未来几十年。

DESCRIPTION (provided by applicant): Natural products provide diverse resources in the development of new drugs for cancer treatment and prevention. Cancer chemoprevention is defined as an approach for the prevention, delay, or reversal of carcinogenesis. To discover and develop new cancer chemo preventive agents, many natural product researchers and medicinal chemists have focused on the exploration of plants with biological activity in bioassays designed to detect potential cancer preventive agents and the isolation of natural products as lead molecules, as well as modification of the active components for further synthesis. Recent advances in the chemistry of novel bioactive natural products provide improvement and development of new drugs. For the purpose of prevention of complex diseases such as cancer, there have been tremendous efforts of diverse groups of scientists working together to develop new and safe drugs from naturally-occurring resources. In order to review recent progress in this area and help to define a path to the future, we have assembled a group of internationally renowned experts in cancer prevention to participate in a symposium and present their recent work. Principal topics of the session will be potential chemopreventive agents developed from natural products and medicinal plants. The meeting will cover preclinical, clinical and epidemiological data in the area of cancer prevention research with compounds, either naturally occurring or derived from natural products components. There will be ten invited speakers for the session. Further discussion on the future direction of natural product research in the area of cancer prevention will be of great interest. At the start of the symposium, a lecture will be presented to overview the lectures to come, highlight the challenges of the field, and set the stage for the proceedings to come. The objective of the session is to critically evaluate progress and begin to chart of course for future work. Each lecture will include questions and answers and discussion. At the end of the session, a round table discussion will be moderated that will include each of the speakers and the audience. The symposium will be conducted as part of the 50th Annual Meeting of the Phytochemical Society of North America that will be held during the period of December 10-14, 2011, on the Kohala Coast of the Big Island of Hawaii. We will employ all of the resources assembled by the meeting organizers to assure the success of this symposium. The audience will be diverse and international. The venue is centrally located to facilitate East/West interaction. Very favorable hotel rates have been secured to promote broad attendance including graduate students and other trainees. It is expected the attendees will reflect broad diversity. The proceedings of the symposium will be published by Springer in their renowned series entitled Topics in Current Chemistry (impact factor 5.270; 2009). Each chapter as well as the preface will acknowledge presentation at the meeting and support provided by the NIH. This will be a landmark achievement in the field of cancer chemoprevention. PUBLIC HEALTH RELEVANCE: Prevention of cancer is a safe and effective way to reduce human suffering. In principle, cancer chemoprevention could play a role as dominant as vaccines in the prevention of disease. Nonetheless, despite the great promise of this approach, progress has been hampered. We propose to organize a meeting that will bring outstanding researchers from both cancer prevention and natural products research field together. The objective is to increase communication, disseminate new findings, prepare a platform for increased collaborations in the use and development of novel components and their derivatives from natural products as potential cancer preventive agents, and to explore and define barriers and ways to overcome these barriers. A prevention approach with natural products is an important part of cancer prevention strategies for improving general public health. We believe that the conference may contribute to achieving the goal of the NIH, and will provide a better understanding and approaches to reduce cancer incidence and mortality in the coming decades.