Natural Products in the Prevention of Cancer

描述（由申请人提供）：天然产物为癌症治疗和预防新药的开发提供了多样化的资源。癌症化学预防被定义为一种预防、延缓或逆转癌变的方法。为了发现和开发新的癌症化学预防药物，许多天然产物研究者和药物化学家都把重点放在探索具有生物活性的植物上，用于设计生物测定法来检测潜在的癌症预防药物，以及天然产物作为先导分子的分离，以及对活性成分进行修饰以进一步合成。新的生物活性天然产物化学的最新进展为新药的改进和开发提供了条件。为了预防像癌症这样的复杂疾病，不同的科学家群体已经付出了巨大的努力，共同努力从自然资源中开发新的和安全的药物。为了回顾这一领域的最新进展，并帮助确定未来的道路，我们召集了一群国际知名的癌症预防专家参加研讨会，并介绍他们最近的工作。会议的主要议题将是从天然产物和药用植物中开发的潜在化学预防剂。会议将涵盖使用天然存在或从天然产品成分中提取的化合物进行癌症预防研究领域的临床前、临床和流行病学数据。这次会议将邀请十位演讲者。进一步讨论天然产物在癌症预防领域的未来研究方向将是非常有趣的。在研讨会开始时，将有一个讲座来概述即将到来的讲座，突出该领域的挑战，并为即将到来的会议做好准备。会议的目标是批判性地评价进展情况，并开始为今后的工作规划方向。每堂课将包括问答和讨论。在会议结束时，将主持一次圆桌讨论，包括每位演讲者和观众。该研讨会将作为第50届北美植物化学学会年会的一部分进行，该年会将于2011年12月10日至14日在夏威夷大岛的Kohala海岸举行。我们将利用会议组织者汇集的所有资源，确保本次研讨会取得成功。观众将是多样化和国际化的。场地位于中心位置，方便东西方交流。我们保证了非常优惠的酒店价格，以促进包括研究生和其他培训生在内的广泛出席。预计与会者将反映出广泛的多样性。会议记录将由施普林格在其著名的题为“当前化学主题”系列中发表（影响因子5.270;2009）。每一章以及前言都将感谢在会议上的介绍和NIH提供的支持。这将是癌症化学预防领域的一个里程碑式的成就。

DESCRIPTION (provided by applicant): Natural products provide diverse resources in the development of new drugs for cancer treatment and prevention. Cancer chemoprevention is defined as an approach for the prevention, delay, or reversal of carcinogenesis. To discover and develop new cancer chemo preventive agents, many natural product researchers and medicinal chemists have focused on the exploration of plants with biological activity in bioassays designed to detect potential cancer preventive agents and the isolation of natural products as lead molecules, as well as modification of the active components for further synthesis. Recent advances in the chemistry of novel bioactive natural products provide improvement and development of new drugs. For the purpose of prevention of complex diseases such as cancer, there have been tremendous efforts of diverse groups of scientists working together to develop new and safe drugs from naturally-occurring resources. In order to review recent progress in this area and help to define a path to the future, we have assembled a group of internationally renowned experts in cancer prevention to participate in a symposium and present their recent work. Principal topics of the session will be potential chemopreventive agents developed from natural products and medicinal plants. The meeting will cover preclinical, clinical and epidemiological data in the area of cancer prevention research with compounds, either naturally occurring or derived from natural products components. There will be ten invited speakers for the session. Further discussion on the future direction of natural product research in the area of cancer prevention will be of great interest. At the start of the symposium, a lecture will be presented to overview the lectures to come, highlight the challenges of the field, and set the stage for the proceedings to come. The objective of the session is to critically evaluate progress and begin to chart of course for future work. Each lecture will include questions and answers and discussion. At the end of the session, a round table discussion will be moderated that will include each of the speakers and the audience. The symposium will be conducted as part of the 50th Annual Meeting of the Phytochemical Society of North America that will be held during the period of December 10-14, 2011, on the Kohala Coast of the Big Island of Hawaii. We will employ all of the resources assembled by the meeting organizers to assure the success of this symposium. The audience will be diverse and international. The venue is centrally located to facilitate East/West interaction. Very favorable hotel rates have been secured to promote broad attendance including graduate students and other trainees. It is expected the attendees will reflect broad diversity. The proceedings of the symposium will be published by Springer in their renowned series entitled Topics in Current Chemistry (impact factor 5.270; 2009). Each chapter as well as the preface will acknowledge presentation at the meeting and support provided by the NIH. This will be a landmark achievement in the field of cancer chemoprevention. PUBLIC HEALTH RELEVANCE: Prevention of cancer is a safe and effective way to reduce human suffering. In principle, cancer chemoprevention could play a role as dominant as vaccines in the prevention of disease. Nonetheless, despite the great promise of this approach, progress has been hampered. We propose to organize a meeting that will bring outstanding researchers from both cancer prevention and natural products research field together. The objective is to increase communication, disseminate new findings, prepare a platform for increased collaborations in the use and development of novel components and their derivatives from natural products as potential cancer preventive agents, and to explore and define barriers and ways to overcome these barriers. A prevention approach with natural products is an important part of cancer prevention strategies for improving general public health. We believe that the conference may contribute to achieving the goal of the NIH, and will provide a better understanding and approaches to reduce cancer incidence and mortality in the coming decades.