Gene-Environment Interactinos Training Program

基因-环境相互作用培训计划

• 批准号: 8103268
• 负责人: Daniel W. Nebert
• 金额: $ 47.32万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8103268
• 关键词: Environment; Genes; Training Programs

DESCRIPTION (provided by applicant) The goal of the Gene-Environment Interactions Training Program (GEITP) is to train pre-doctoral and post-doctoral students who will be versed in ways that both environment exposure and genetics diversity interact to alter the onset of disease. Achieving this objective requires an interdisciplinary team approach integrating an understanding of genetic diversity, epigenetic alterations, high-throughput genomics, biostatistics, biomarkers, and exposure assessment approaches. The collaborative efforts of research faculty, clinicians, postdoctoral and pre-doctoral trainees are needed in order to meet this objective. A mentorship team approach, combining the expertise of well-regarded scientists in the areas of exposure assessment, genetic variability, biomarkers of disease, and individual/tailored medicine will be used to educate trainees in multiple areas of gene-environment interactions. Pre-doctoral training will include required coursework in addition to the student's matriculated Ph.D. program, laboratory rotations with the team of mentors, and hands-on work in several areas of exposure assessment, high-throughput genetic variability measures, and biomarkers or exposure and/or disease. Postdoctoral training will include programs in laboratory and personnel management, pilot grant applications, and an intensive year long grant writing workshop to prepare them for independent research. All trainees will be required to attend "Technologies in genomics, exposure, a biomarkers" workshop, which will be created as part of this program, and present research results at an annual GEITP Student Symposium. This program will include a dedicated governance structure to assure that appropriate trainees are recruited, education goals are met, and the aims of this grant are achieved.

描述（由申请人提供） 基因-环境相互作用培训计划（GEITP）的目标是培养博士前和博士后学生，他们将精通环境暴露和遗传多样性相互作用以改变疾病发作的方式。实现这一目标需要一个跨学科的团队方法，整合遗传多样性，表观遗传改变，高通量基因组学，生物统计学，生物标志物和暴露评估方法的理解。为了实现这一目标，需要研究人员、临床医生、博士后和博士前学员的合作努力。导师团队的方法，结合了在暴露评估，遗传变异性，疾病的生物标志物和个人/定制医学领域的知名科学家的专业知识，将用于教育学员在基因-环境相互作用的多个领域。除了学生的入学博士学位外，博士前培训还将包括所需的课程作业计划、与导师团队的实验室轮换以及暴露评估、高通量遗传变异性测量以及生物标志物或暴露和/或疾病等多个领域的实践工作。博士后培训将包括实验室和人事管理，试点资助申请，以及为期一年的密集资助写作研讨会，为他们的独立研究做好准备。所有学员都将被要求参加作为该计划一部分创建的“基因组学、暴露、生物标志物技术”研讨会，并在年度GEITP学生研讨会上展示研究成果。该计划将包括一个专门的治理结构，以确保招募适当的受训人员，实现教育目标，并实现该赠款的目标。