Research Training Program in Gastroenterology

描述（由申请人提供）： 这个胃肠病学研究培训计划的主要目的是准备医学博士，博士、医学博士/哲学博士、博士后研究员和博士前学生，作为学术胃肠病学的医生/科学家和/或独立研究者。有八个多方面的教师，为未来的学员提供当代细胞/分子生物学，肿瘤发生，信号转导途径，病毒学，免疫学，干细胞生物学和生物化学方法的机会。教师已从医学系，儿科，布朗大学病理生物学和分子和细胞生物学（MCB）计划招募，所有经营资金充足的研究计划（每年直接费用约480万美元）。在这种情况下，有一个重大的努力，以提供机会，在转化研究在肝脏研究中心和罗得岛医院。在这些设施中，可以使用定量成像、激光捕获显微切割、基因组学和蛋白质组学、流式细胞术、转基因动物和人体组织库。博士前学员从病理生物学和MCB研究生课程招募，并进入生物学，化学和细胞生物学专业。这些学生致力于人类疾病机制的基础研究。博士后学员从多个来源招募，包括布朗大学和其他地方的研究生课程，以及那些在布朗大学/附属医院临床成人和儿科胃肠病学奖学金计划中完成至少两年的人。我们要求两名博士后医学博士，医学博士，博士或博士受训人员将投入两到三年的时间进行基础或转化研究。医学博士的研究工作将占90%。或医学博士/博士，博士博士后100%。有两名博士预科生申请进入医学博士课程，医学博士/博士或博士布朗大学的研究生课程。受训人员将接受负责任的研究指导，并有机会在培训计划期间发展沟通和教学技能。博士前和博士后学员都需要参加教学课程，这些课程通过每周的研究研讨会，期刊俱乐部，职业发展研讨会和研讨会来丰富。有一个强大的指导计划，以发展沟通，grananimation，跨学科互动的技能，并实施基础研究方法，用于诊断和预防胃肠道疾病。该培训计划致力于为少数民族博士前和博士后学员提供机会，并有一个强大的计划来招募代表性不足的少数民族候选人。因此，布朗大学/Lifespan附属医院计划旨在发展胃肠病学和肝病学的学术事业。 公共卫生相关性：该补助金是针对胃肠道和肝脏疾病的培训方案。受训人员由博士前和博士后候选人与MD，博士，或两个学位。该计划的一个主要重点是培养生物医学科学家和医生科学家使用最先进的调查技术。

DESCRIPTION (provided by applicant): The major thrust of this Gastroenterology Research Training Program is to prepare the M.D., Ph.D, M.D./Ph.D., post-doctoral fellow, and pre-doctoral student for a career as a physician/scientist and/or independent investigator in academic Gastroenterology. There are eight multi-faceted faculty to provide prospective trainees opportunities in contemporary approaches to cellular/molecular biology, oncogenesis, signal transduction pathways, virology, immunology, stem cell biology, and biochemistry. Faculty have been recruited from the Department(s) of Medicine, and Pediatrics, and from the Brown University Pathobiology and the Molecular and Cellular Biology (MCB) Program and all operate well-funded research programs (approximately $4.8 million annual direct costs). In this context, there is a major effort to provide opportunities in translational research at the Liver Research Center and Rhode Island Hospital. In these facilities, there is access to quantitative imaging, laser capture micro-dissection, genomics and proteomics, flow cytometry, transgenic animals, and human tissue banks. The pre-doctoral trainees are recruited from the Pathobiology and MCB Graduate Program(s), and enter with majors in biology, chemistry, and cell biology. These students have a commitment to basic research on the mechanisms of human disease. The Post-doctoral trainees are recruited from several sources including the graduate programs at Brown and elsewhere as well as those having completed the minimum of two years in the Brown University/Affiliated Hospital Clinical Adult and Pediatric Gastroenterology Fellowship Program. We request two postdoctoral M.D., M.D., Ph.D. or Ph.D. trainees who will devote two or three years to basic or translational research. The research effort will be 90% for M.D. or M.D./Ph.D, and 100% for Ph.D post-doctoral Fellows. There is a request for two pre-doctoral trainees enrolled in the M.D., M.D./Ph.D. or Ph.D. graduate programs at Brown University. The trainees are instructed in the responsible conduct of research and have the opportunity to develop communication and teaching skills during the training program. Both pre- and post-doctoral trainees are required to participate in didactic courses that are enriched by weekly research seminars, journal clubs, career development workshops, and symposia. There is a strong mentoring program to develop skills in communication, grantsmanship, interdisciplinary interactions, and the implementation of basic research approaches for the diagnosis and prevention of gastrointestinal diseases. The training program is committed to offering opportunities to minority pre- and postdoctoral trainees, and there is a robust program to recruit underrepresented minority candidates. Thus the Brown University/Lifespan Affiliated Hospital Program is designed to develop academic careers in Gastroenterology and Hepatology. PUBLIC HEALTH RELEVANCE: This grant is a Training Program for diseases of the gastrointestinal tract and liver. Trainees are comprised of pre-doctoral and post-doctoral candidates with the MD, PhD, or both degrees. A major emphasis of the program is to train biomedical scientist and physician scientist using state of the art investigative techniques.