权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

ISOLATED EXECUTIVE IMPAIRMENT AND COGNITIVE DECLINE

孤立的执行力障碍和认知能力下降

基本信息

批准号：
8141582
负责人：
JULENE K JOHNSON
金额：
$ 6.03万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-01 至 2011-09-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The majority of studies of cognitive aging focus on memory decline and Alzheimer's disease (AD). However, the preclinical stage of AD and other dementias may also begin with impairment in non-memory cognitive domains. We have preliminary clinical and neuropathological data suggesting that isolated executive impairment, a non-memory cognitive deficit, may be a risk for the development of functional decline and/or dementia. The overall goal of this project is to test the hypothesis that an isolated impairment of frontalexecutive function in non-demented elderly will predict future cognitive decline / dementia, functional impairment, and brain atrophy. To test this hypothesis, we will obtain longitudinal cognitive, functional, and neuroimaging measurements of 48 elderly subjects with isolated executive impairment and compare with 48 subjects with amnestic mild cognitive impairment (MCI) and matched controls. Specifically, we predict that lower baseline performance on tests of executive function will be associated with 1) lower performance on functional measures (i.e., activities of daily living) at two- and four-year follow-up intervals and 2) a decline in cognitive performance at two- and four-year follow-up intervals when compared with matched controls. We also hypothesize that subjects with isolated executive impairment will have a greater degree of prefrontal cortex atrophy on MRI at baseline and show a faster rate of prefrontal cortex atrophy at the two-year follow-up interval. Across all subjects, we predict that there will a relationship between scores on tests of executive function and the degree of frontal cortex atrophy. This project will increase awareness of non-memory cognitive impairment as a significant risk for functional and cognitive decline and/or dementia, 2) provide clinical and neuroimaging tools for the identification of individuals with non-memory cognitive impairment for possible inclusion in future primary prevention and treatment trials, and 3) expand differential diagnosis with individuals who present with isolated executive impairment to include AD in addition to frontotemporal dementia, vascular dementia, etc.

描述（由申请人提供）：大多数认知衰老的研究集中在记忆衰退和阿尔茨海默病（AD）上。然而，阿尔茨海默病和其他痴呆症的临床前阶段也可能开始于非记忆认知领域的损害。我们有初步的临床和神经病理学数据表明，孤立的执行障碍，一种非记忆性认知缺陷，可能是功能衰退和/或痴呆发展的风险。这个项目的总体目标是验证一个假设，即在非痴呆老年人中，单独的额执行功能损伤可以预测未来的认知能力下降/痴呆、功能损伤和脑萎缩。为了验证这一假设，我们将获得48例孤立性执行障碍老年受试者的纵向认知、功能和神经影像学测量结果，并与48例遗忘性轻度认知障碍（MCI）受试者和匹配对照进行比较。具体来说，我们预测执行功能测试中较低的基线表现将与以下因素相关：1)在2年和4年的随访间隔中，功能测量（即日常生活活动）的表现较低；2)与匹配的对照组相比，在2年和4年的随访间隔中，认知表现下降。我们还假设孤立性执行功能障碍的受试者在基线时的MRI上有更大程度的前额皮质萎缩，并且在两年的随访间隔中显示出更快的前额皮质萎缩速度。在所有受试者中，我们预测执行功能测试的分数与额叶皮质萎缩程度之间存在关系。该项目将提高人们对非记忆性认知障碍作为功能和认知能力下降和/或痴呆的重要风险的认识，2)为识别非记忆性认知障碍患者提供临床和神经影像学工具，以便可能纳入未来的初级预防和治疗试验，以及3)扩大对孤立性执行障碍患者的鉴别诊断，将AD纳入额颞叶痴呆。血管性痴呆等。