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Mechanisms of chromatin regulation that drive HIV latency

Mechanisms of chromatin regulation that drive HIV latency
驱动 HIV 潜伏期的染色质调控机制
批准号：
8138949
负责人：
DAVID M. MARGOLIS
金额：
$40.49万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-09-15 至 2012-08-31
来源：
https://reporter.nih.gov/project-details/8138949
关键词：
Biological AssayCD4 Positive T LymphocytesCell CycleCell LineCell NucleusCell modelCellsChromatinChromatin StructureChronicClinicalClinical ResearchCollaborationsComplexDistantDoseDrug Delivery SystemsEmodinEnzymesEpigenetic ProcessFutureGenesGenetic TranscriptionGoalsHIVHIV InfectionsHighly Active Antiretroviral TherapyHistone DeacetylaseHistone Deacetylase InhibitorHistonesIL7 geneImmune systemIn VitroIndividualInfectionLaboratoriesLeadLifeLymphoid TissueMaintenanceMediatingMemoryModelingMolecularMorbidity - disease ratePatientsPlayPolypyrimidine Tract-Binding ProteinPopulationPositive Transcriptional Elongation Factor BPreventionProteinsProvirusesRNARecoveryRecruitment ActivityRegulationRepressionResearchRestRoleSignal TransductionT memory cellT-Cell ActivationTechnologyTherapeuticTherapeutic InterventionToxic effectTransitional CellTranslationsValproic AcidViralWorkadvanced diseaseantiretroviral therapybasechromatin immunoprecipitationchromatin modificationchromatin remodelingcofactorcostfactor EF-Pimprovedin vivoinhibitor/antagonistlatent infectionmortalitynovelpandemic diseaseperipheral bloodpromoterpublic health relevanceresearch studyresponsesmall moleculesuccesstherapeutic target

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