Role of PKA in autoimmune diabetes through dendritic cells (DC) and regulatory T

PKA 通过树突状细胞 (DC) 和调节性 T 在自身免疫性糖尿病中的作用

• 批准号: 8125445
• 负责人: Hua Gu
• 金额: $ 40.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125445
• 关键词: Ablation; Adoptive Transfer; Affect; Antigens; Autoantigens; Autoimmune Diabetes; Autoimmune Diseases; Autoimmunity; Biological Models; CD28 gene; CD4 Positive T Lymphocytes; CD80 gene; Cell physiology; Cells; Cyclic AMP-Dependent Protein Kinases; Data; Dendritic Cells; Development; Diabetes Mellitus; Diabetic mouse; Exhibits; Foundations; Goals; Homeostasis; Immune; Immune response; Inbred NOD Mice; Individual; Insulin-Dependent Diabetes Mellitus; Interleukin-10; Interleukin-2; Lead; Lymphoid; Mediating; Molecular; Mouse Strains; Mus; Mutation; NF-kappa B; Organ; Pathway interactions; Peripheral; Phenotype; Play; Prevention; Reagent; Regimen; Regulation; Regulatory T-Lymphocyte; Reporting; Role; Signal Transduction; Supporting Cell; T-Lymphocyte; Testing; Therapeutic; Therapeutic Effect; Thymus Gland; Transgenic Mice; Vitamin D; Vitamin D3 Receptor; autoreactive T cell; base; cytokine; in vitro Assay; insight; mutant; p65; prevent; public health relevance