Development of an activity based probe family for metallo aminopeptidases

开发基于活性的金属氨肽酶探针家族

• 批准号: 8134639
• 负责人: Doron Greenbaum
• 金额: $ 37.23万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8134639
• 关键词: Address; Advanced Practice Nurse; Amino Acids; Aminopeptidase; Antimalarials; Binding; Biochemical; Biological; Biology; Cells; Cessation of life; Chemicals; Chemistry; Clinical; Critical Pathways; Development; Digestion; Disease; Drug resistance; Enzymes; Erythrocytes; Evaluation; Family; Genetic; Genetic Techniques; Genome; Genomics; Hemoglobin; Human; Hydrolysis; In Vitro; Leucine Aminopeptidase; Libraries; Life; Life Cycle Stages; Malaria; Mediating; Methods; Molecular Genetics; Organism; Orthologous Gene; Parasites; Pathologic Processes; Pathway interactions; Peptide Hydrolases; Peptides; Phase; Plasmodium; Plasmodium falciparum; Proteins; Proteomics; Recombinants; Role; Route; Solid; Specificity; Techniques; Ubenimex; Validation; Zinc; abstracting; alanine aminopeptidase; base; biological systems; chemical genetics; design; improved; inhibitor/antagonist; novel; overexpression; pathogen; public health relevance; scaffold; small molecule; tool