Clinical Evaluation of an Ultrasound Based Imaging System for Guiding Cardiac Abl

描述（由申请人提供）：我们建议临床评估一种新型心内ARFI超声成像系统结合电解剖定位系统指导射频消融治疗心房颤动和心房扑动的能力。同时，我们将与工业合作伙伴西门子超声合作，将这些技术迁移到3D超声成像平台，并开发两种优化的心脏内探头，用于3D b模式/ARFI联合成像。研究人员建议对3D扫描仪/探针和相关的脉冲序列、波束形成方法以及待开发的信号和图像处理方法进行幻影、动物和最终的人体研究。

DESCRIPTION (provided by applicant): We propose to clinically evaluate the ability of a novel intracardiac ARFI ultrasound imaging system combined with an electro-anatomic mapping system to guide radio-frequency ablations procedures for treating atrial fibrillation and atrial flutter. In parallel, and in collaboration with our industrial partner Siemens Ultrasound, we will migrate these technologies to a 3D ultrasonic imaging platform and develop two intracardiac probes optimized for combined 3D B-mode/ARFI imaging. Phantom, animal and, ultimately, human studies are proposed to evaluate the 3D scanner/probes and the related pulse sequences, beam forming methods and signal and image processing methods to be developed. If successful, the proposed methods will provide the electrophysiologist with real-time visualization of cardiac ablation lesions and with the ability guide the creation of these lesions. As such, the proposed studies could markedly reduce treatment times for atrial and ventricular cardiac ablation procedures, prevent complications from over ablation and reduce the rates of repeat procedures. PUBLIC HEALTH RELEVANCE: We propose to move from the laboratory to the clinic the technique we developed in Phase I for image guided ablation therapy. This system can show the physician regions of the heart which have already been treated. Currently physicians have no means to examine these regions. In Phase I we successfully built the system and demonstrated its efficacy. In phase II we plan a series of clinical tests to demonstrate its utility for treating atrial arrhythmias in patients.