RHUBARB AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR STUDY RACE II

大黄和血管紧张素转换酶抑制剂研究竞赛 II

• 批准号: 8167020
• 负责人: John M. Burkart
• 金额: $ 0.29万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167020
• 关键词: Adult; Angiotensin-Converting Enzyme Inhibitors; Asians; China; Chinese Herbs; Computer Retrieval of Information on Scientific Projects Database; Constipation; Country; Diabetes Mellitus; Double-Blind Method; Funding; Grant; Institution; Patients; Plant Preparations; Race; Randomized; Research; Research Design; Research Personnel; Resources; Rhubarb food; Source; TNF gene; Transforming Growth Factor beta; United States National Institutes of Health; placebo controlled study; prevent; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients in China has suggested that rhubarb extract when used alone is equivalent to the protection afforded by ACEI. Furthermore when used in combination with ACEI, the renoprotective effect of rhubarb appears to be additive. Rhubarb extract is a chinese herbal preparation that is used extensively in china and other asian countries to treat constipation and CKD. Its mechanism of action in preventing progression of CKD is uncertain but perhaps related to TGF beta and TNF alph inhibition. The proposed study will be a prospective randomized double blinded placebo controlled study design to evaluate the efficacy of Rhubarb in addition to ACEI in proventing progression of CKD in adult patients with diabetes.

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