LIPID AND LIPOPROTEIN METABOLISM IN ATHEROSCLEROSIS (CORE A)

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 一般来说，HDL（“好胆固醇”）与冠状动脉疾病的风险呈负相关（即一个人拥有的HDL越多，这个人患冠状动脉疾病的可能性就越小）。 然而，虽然这对人群来说是正确的，但事实上，大约40%至45%的心脏病发作发生在HDL水平完全正常的受试者中。我们的初步研究表明，来自正常个体（即那些没有已知的冠状动脉疾病的人）的HDL能够抑制脂质氧化并且是抗炎的。相比之下，我们在这项初步研究中发现，患有冠状动脉疾病的HDL-胆固醇水平正常的个体几乎总是HDL功能失调。他们的HDL抑制脂质氧化的能力较低，实际上可能会促进脂质氧化，而不是抗炎，他们的HDL是促炎的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In general HDL (the "good cholesterol") is inversely correlated for risk for coronary artery disease (i.e. the more HDL a person has, the less likely it is that the person will have coronary artery disease). However, while this is true for populations, in fact about 40 to 45% of all heart attacks occur in subjects with perfectly normal HDL levels. Our preliminary research has shown that HDL from normal individuals (.i.e those without known coronary artery diseas) is able to inhibit lipid oxidation and is ant-inflammatory. In contrast, we have found in this preliminary research that individuals with normal HDL-cholesterol levels who have coronary artery disease almost always have HDL that is dysfunctional. Their HDL is less able to inhibit lipid oxidation and in fact may actually promote lipid oxidation and instead of being anti-inflammatory, their HDL is pro-inflammatory.