Oxidative regulation of the Na pump- a new player in vascular function in health and disease

钠泵的氧化调节——健康和疾病中血管功能的新参与者

• 批准号: nhmrc : 1080468
• 负责人: A/Pr Ravinay Bhindi
• 金额: $ 33.64万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/oxidative-regulation-na-health-disease/518747
• 关键词: Oxidative; regulation; Na; pump; new

Oxidative stress is a major player in hypertension, atherosclerosis, diabetes and ageing, but we have struggled to develop a therapy to successfully combat in heart and vascular cells in large clinical trials. We have discovered a new role for membrane protein FXYD1, to protect key heart and vascular proteins from functional impairment secondary to oxidative stress. We will investigate its role in protecting against vascular disease, and test novel therapies based on this endogenous protector.

氧化应激是高血压、动脉粥样硬化、糖尿病和衰老的主要因素，但我们一直在努力开发一种治疗方法，在大型临床试验中成功地对抗心脏和血管细胞。我们发现了膜蛋白FXYD1的新作用，可以保护关键的心脏和血管蛋白免受氧化应激引起的功能损伤。我们将研究其在预防血管疾病中的作用，并测试基于这种内源性保护剂的新疗法。