用于细胞内药物输送的生物功能聚合物-猫眼课题宝

用于细胞内药物输送的生物功能聚合物

批准号：

8037129

负责人：

Patrick S. Stayton

金额：

$50.74万

依托单位：

UNIVERSITY OF WASHINGTON

依托单位国家：

美国

项目类别：

财政年份：

2003

资助国家：

美国

项目状态：

已结题

起止时间：

2003-09-19 至 2013-02-28

来源：

https://reporter.nih.gov/project-details/8037129

关键词：

Animal Model Antibodies Antisense Oligonucleotides Architecture Area Biodistribution Biological Assay Biological Response Modifier Therapy Blood Circulation Burkitt Lymphoma CD22 gene Cell Culture Techniques Cells Charge Chemicals Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Clinical Clinical Treatment Clinical Trials DNA Dependence Development Drug Delivery Systems Drug Formulations Drug Kinetics Drug Stability Elements Equilibrium Erythrocytes Exhibits Follicular Lymphoma Gene Silencing Gene Targeting Grant Health Hematologic Agents Hemolysis Ions Label Lymphoma Lysosomes Malignant Neoplasms Measurement Membrane Messenger RNA Methods Modeling Mus Non-Hodgkin&apos s Lymphoma Nuclear Nucleic Acids Nude Mice Oncogenes Organism Pathogenesis Pathologic Penetration Pharmaceutical Preparations Polymers Property Protein Family Proteins RNA Radio Recycling Research Research Personnel Small Interfering RNA System Technology Therapeutic Time Tissues Translations Treatment Efficacy Virus Western Blotting Xenograft procedure anti-cancer therapeutic base copolymer cytotoxic design extracellular fusion gene in vivo leukemia/lymphoma membrane activity neoplastic novel octadecaneuropeptide pH gradient research clinical testing response success therapeutic target

项目摘要

项目成果

Patrick S. Stayton的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

DESCRIPTION (provided by applicant): The objective of this proposal is to develop approaches to enhance the delivery of nucleic acid based therapeutics to intracellular targets in Non-Hodgkin Lymphoma (NHL) cells. The project will utilize novel pH-sensitive "smart polymer" based carriers to penetrate the endosomal barrier that limits entry to the cytoplasmic and nuclear compartments where antisense-ODN and siRNA exert their gene silencing effects. We believe that siRNA and AS-ODN have great potential for the treatment of NHL and hypothesize that improvement in delivery methods will facilitate their success in the clinical setting. PUBLIC HEALTH REVELANCE This project aims to develop new drug delivery systems for biomolecular drugs that must reach intracellular targets for efficacy. Biotherapeutics such as siRNA, antisense oligonucleotides (ODN), and proteins have significant therapeutic potential, but effectively formulating and delivering them remains a widely recognized challenge. Here we will develop smart polymeric carriers for siRNA drugs, and such carriers might be used widely for other DNA, RNA, and protein drugs.

期刊论文(25)

专著(0)

科研奖励(0)

会议论文